Thank you to Klaudija Daugelaite, Ivana Winkler, the Odom and Rehnitz labs (at DKFZ and UKHD), it has been a pleasure working with you. Thank you to the DFG and ERC for funding.

Also, most oocyte aging studies use superovulated cells. Here we show that aging and superovulation lead to qualitatively similar transcriptomic changes, but that superovulation response is milder in old age. This highlights the necessity of including nat. ovulated cells in oocyte aging studies.

Using a mouse model, we characterize the transcriptional maturity of superovulated oocytes and granulosa cells after hormonal stimulation and identify markers in granulosa cells that are predictive of the oocyte early developmental potential.

Increased reproductive age and the development of assisted reproductive technologies (ART) are shaping modern human reproduction. Understanding how these new conditions impact oocyte quality is crucial to improve the efficiency of fertility treatments.

Thank you Elisa!

Thank you Sylvia!