Adrian Olszewski
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adrianolsz.bsky.social
Adrian Olszewski
@adrianolsz.bsky.social
Biostatistician and statistical R programmer in Clinical Trials ⦿ Having fun in a 100% R-based CRO ⦿ Frequentist framework ⦿ 𝘭𝘰𝘨𝘪𝘴𝘵𝘪𝘤 𝘳𝘦𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯 𝘩𝘢𝘴 𝘣𝘦𝘦𝘯 𝘢 𝘳𝘦𝘨𝘳𝘦𝘴𝘴𝘪𝘰𝘯 𝘴𝘪𝘯𝘤𝘦 𝘪𝘵𝘴 𝘣𝘪𝘳𝘵𝘩
Pinned
If you're interested in #RStats in #clinicaltrials, check my two older (2020-2) presentations from the #rinpharma conference on the numerical validation of R. I work in a 100%R CRO, my daily challenges might be interesting.
www.researchgate.net/publication/...
and
www.slideshare.net/AdrianOlszew...
(PDF) Numerical validation as a critical aspect in bringing R to the Clinical Research
PDF | Validation of the R statistical package has become a hot topic since 2015, when the FDA issued the Statistical Software Clarifying Statement,... | Find, read and cite all the research you need o...
www.researchgate.net
Two examples of using logistic regression (&friends) for model-based testing hypotheses & estimation. I show the equivalence of Wald's "z" statistic for two proportions with pooled and unpooled variance vs logistic r. + AME / Rao.
1: medium.com/@r.clin.res/...
2: medium.com/@r.clin.res/...
#stats
Testing hypotheses about proportions (%) through the logistic regression (and friends) — part II
In my previous article titled “Is logistic regression a regression? It has been a regression since its birth — and is used this way every…
medium.com
March 22, 2025 at 10:52 AM
#stats Sometimes, at work, I feel like I'm the only person who cares about the success of the study...
March 1, 2025 at 4:09 PM
That's how it sometimes looks like when #stats (here: in clinical #biostatistics) meets #machinelearning with a little 𝘪𝘮𝘱𝘦𝘥𝘢𝘯𝘤𝘦 𝘮𝘪𝘴𝘮𝘢𝘵𝘤𝘩 on some topic common in both places 🙃 (happened to me twice so far).
January 29, 2025 at 2:34 AM
- Adrian, logistic regression is NOT a regression, it's a classifier!
- O'rly? I've never used it for classification while using it daily at work to test hypotheses and explore treatment effects😬 I bet #stats guys who invented it didn't know this... revelation too 🙄
#ml #machinelearning #datascience
December 30, 2024 at 2:04 PM
The moment, when you feel the nonsense of 𝙋𝙊𝙎𝙏-𝙃𝙊𝘾 𝙋𝙊𝙒𝙀𝙍 and yet the same concept is essential for👉 𝙙𝙚𝙨𝙞𝙜𝙣𝙞𝙣𝙜 𝙨𝙩𝙪𝙙𝙞𝙚𝙨, namely calculating the sample size:
1) to determine the safety range for dropouts
2) when there's no closed-form formula (like for the Fisher exact test)
#statistics #stats #rstats
December 18, 2024 at 4:51 PM
#statistics #stats Reading QQ plots is not easy at first. I can relate! But don't give up just because it's hard. Everything is hard until you know it and suddenly it becomes your daily tool. Practising and mastering QQ plots (and CDF, BTW) isn't a waste of time! Below I show a few examples.
December 14, 2024 at 12:35 PM
#rstats #ggplot2 I must say I really *like* the gghalves package and the idea of the #raincloud plots 🥰
In my toolkit (#clinicaltrials) for 8 years. Below - various examples (from toy experiments and real reports). Luckily to me, my collaborators love them too (and even demand!).
December 10, 2024 at 1:31 PM
Anscombe's quartet, Datasaurus dozen... I wanted to make my own set with same (basic) descriptive summaries. Let me introduce the Olszewski's quartet 😎
Yeah, I could easily make both kurtosis and skewness equal too, but I like the asymmetry of the nose and eyes 😂
github.com/adrianolszew...
#rstats
December 10, 2024 at 3:24 AM
For ~15yrs on ~weekly basis at work you've been using the logistic regression for exploring main & simple effects + interactions & testing hypotheses, and suddenly a #ML guru tells you that "nope, logistic regression is not a regression, it gives 0/1😎". And pufff! - you disappear like in Disney's💥🤦‍♂️
December 5, 2024 at 7:34 AM
Worth remembering: rank-based tests like Kruskal-Wallis, Mann-Whitney (-Wilcoxon), ATS/WTS - do NOT compare medians unless IID holds (=same shape & dispersion). Otherwise, stochastic superiority is assessed. Use quantile regression (+ Wald's testing) or Brown-Mood instead.
#statistics #datascience
December 4, 2024 at 10:21 AM
My "hello world" post 🫡 - a few slides about a viewpoint called 𝙌𝙪𝙚𝙩𝙞𝙡𝙞𝙨𝙢𝙪𝙨 (after Adolphe Quetelet), which initiated the "cult" of the normal distribution I've been observing for years.
www.slideshare.net/slideshow/ch...
Or a longer text: www.2kmm.pl/blog/On-the-...
#statistics #ml #datascience
Challenging the cult of the normal distribution in science
Challenging the cult of the normal distribution in science - Download as a PDF or view online for free
www.slideshare.net
December 4, 2024 at 9:51 AM
If you're interested in #RStats in #clinicaltrials, check my two older (2020-2) presentations from the #rinpharma conference on the numerical validation of R. I work in a 100%R CRO, my daily challenges might be interesting.
www.researchgate.net/publication/...
and
www.slideshare.net/AdrianOlszew...
(PDF) Numerical validation as a critical aspect in bringing R to the Clinical Research
PDF | Validation of the R statistical package has become a hot topic since 2015, when the FDA issued the Statistical Software Clarifying Statement,... | Find, read and cite all the research you need o...
www.researchgate.net
December 4, 2024 at 5:46 AM