ACIR
@acir-org.bsky.social
Accelerating Cancer Immunotherapy Research. A free weekly digest of the latest findings in #cancer #immunotherapy. We spotlight promising research and attend major meetings. We also make cool images :)
Damle and Carter et al. integrated spatial proteomics, tissue microarray, multiplex immunofluorescence imaging, and transcriptomics data from highly desmoplastic fibrolamellar carcinoma, and [...] bit.ly/4ohk276
November 28, 2025 at 4:30 PM
Damle and Carter et al. integrated spatial proteomics, tissue microarray, multiplex immunofluorescence imaging, and transcriptomics data from highly desmoplastic fibrolamellar carcinoma, and [...] bit.ly/4ohk276
Taking advantage of low IL-9R expression in normal tissues, Jiang et al. engineered T cells with wild-type IL-9R. bit.ly/4prS4Xo
November 28, 2025 at 12:30 PM
Taking advantage of low IL-9R expression in normal tissues, Jiang et al. engineered T cells with wild-type IL-9R. bit.ly/4prS4Xo
Baiu et al. showed that CD4+ invariant natural killer T cells (iNKT) and autologous or allogeneic monocyte-derived DCs formed stable complexes, with enhanced expression of MHC I, 4-1BBL, OX40L, and IL-15Ra in DCs, and CD70 in iNKT cells. bit.ly/3XjyUXO
November 27, 2025 at 4:30 PM
Baiu et al. showed that CD4+ invariant natural killer T cells (iNKT) and autologous or allogeneic monocyte-derived DCs formed stable complexes, with enhanced expression of MHC I, 4-1BBL, OX40L, and IL-15Ra in DCs, and CD70 in iNKT cells. bit.ly/3XjyUXO
Dong et al. encoded the ICD-inducing protein 4HB in LNPs optimized for tumor cell specificity and hepatocyte avoidance, which significantly improved tumor cargo expression compared to a clinical control LNP (>90% vs. ~25%). bit.ly/4p42Nrq
November 27, 2025 at 12:00 PM
Dong et al. encoded the ICD-inducing protein 4HB in LNPs optimized for tumor cell specificity and hepatocyte avoidance, which significantly improved tumor cargo expression compared to a clinical control LNP (>90% vs. ~25%). bit.ly/4p42Nrq
New ‘al-MiTE-y’ TAM reprogramming strategy bit.ly/485QEMs
November 26, 2025 at 3:30 PM
New ‘al-MiTE-y’ TAM reprogramming strategy bit.ly/485QEMs
🆕 The (new) T cell vocabulary: A consensus, modular framework to rationalize T cell description doi.org/10.1038/s415...
November 25, 2025 at 12:00 PM
🆕 The (new) T cell vocabulary: A consensus, modular framework to rationalize T cell description doi.org/10.1038/s415...
Marabelle highlighted that the prognostic value of biomarkers is treatment-dependent, citing the Philadelphia chromosome as a poor prognostic marker for leukemia before imatinib became available, but a key therapeutic target after. #SITC25 bit.ly/3LLunuM
November 24, 2025 at 12:00 PM
Marabelle highlighted that the prognostic value of biomarkers is treatment-dependent, citing the Philadelphia chromosome as a poor prognostic marker for leukemia before imatinib became available, but a key therapeutic target after. #SITC25 bit.ly/3LLunuM
⏰ Is it time to learn? Mining the available data on neoepitopes to understand and predict link.springer.com/ar...
November 23, 2025 at 2:30 PM
⏰ Is it time to learn? Mining the available data on neoepitopes to understand and predict link.springer.com/ar...
👉 An inside job for retroviruses: In vivo delivery of stimulatory cargos to Ts of interest by peptide:MHC-targeted retroviruses science.org/doi/10.1...
November 22, 2025 at 1:30 PM
👉 An inside job for retroviruses: In vivo delivery of stimulatory cargos to Ts of interest by peptide:MHC-targeted retroviruses science.org/doi/10.1...
Moran Amit finished his #SITC25 talk by summarizing that nerve injury, often caused by perineural invasion, drives an immunosuppressive microenvironment, causing resistance to anti-PD-1. bit.ly/3LLunuM
November 21, 2025 at 12:50 PM
Moran Amit finished his #SITC25 talk by summarizing that nerve injury, often caused by perineural invasion, drives an immunosuppressive microenvironment, causing resistance to anti-PD-1. bit.ly/3LLunuM
🔎 Stepping back to get a closer look: Ecotypes of immune cells and cell states across cancer types links to survival doi.org/10.1038/s414...
November 20, 2025 at 12:30 PM
🔎 Stepping back to get a closer look: Ecotypes of immune cells and cell states across cancer types links to survival doi.org/10.1038/s414...
Our #SITC25 recap is out today!
Check out the standout presentations and insights from top institutions and speakers: bit.ly/3LLunuM.
Check out the standout presentations and insights from top institutions and speakers: bit.ly/3LLunuM.
November 19, 2025 at 3:00 PM
Our #SITC25 recap is out today!
Check out the standout presentations and insights from top institutions and speakers: bit.ly/3LLunuM.
Check out the standout presentations and insights from top institutions and speakers: bit.ly/3LLunuM.
Gao, He, and Wang et al. show that Trilaciclib (CDK4/6 inhibitor) inhibits NSCLC progression in immunocompetent, but not immunodeficient, mice bearing s.c. LLC and CMT167 tumors. bit.ly/3WUHX19
November 18, 2025 at 12:30 PM
Gao, He, and Wang et al. show that Trilaciclib (CDK4/6 inhibitor) inhibits NSCLC progression in immunocompetent, but not immunodeficient, mice bearing s.c. LLC and CMT167 tumors. bit.ly/3WUHX19
Heyden et al. show that chromatin organizer SATB1 is enriched in TPEX cells and limits exhausted CD8+ T cell expansion and effector differentiation in chronic infection and cancer, while maintaining functionality. bit.ly/47Dwnhc @thedohertyinst.bsky.social @unimelb.bsky.social
November 17, 2025 at 12:30 PM
Heyden et al. show that chromatin organizer SATB1 is enriched in TPEX cells and limits exhausted CD8+ T cell expansion and effector differentiation in chronic infection and cancer, while maintaining functionality. bit.ly/47Dwnhc @thedohertyinst.bsky.social @unimelb.bsky.social
Bachem, Clarke and Kong et al. studied the role of microbiota-derived short chain fatty acids (SCFAs) in an orthotopic melanoma model, revealing a direct link between melanoma control, CD8+ T cell differentiation [...] bit.ly/4p4v40r @thedohertyinst.bsky.social @unimelb.bsky.social
November 14, 2025 at 4:45 PM
Bachem, Clarke and Kong et al. studied the role of microbiota-derived short chain fatty acids (SCFAs) in an orthotopic melanoma model, revealing a direct link between melanoma control, CD8+ T cell differentiation [...] bit.ly/4p4v40r @thedohertyinst.bsky.social @unimelb.bsky.social
To overcome the immunosuppressive TME in glioblastoma, Lunavat and Nieland et al. identified the cell types involved in tumor control following i.t. IL-12 therapy in mice. bit.ly/3XmwCXQ @harvardmed.bsky.social
November 14, 2025 at 12:45 PM
To overcome the immunosuppressive TME in glioblastoma, Lunavat and Nieland et al. identified the cell types involved in tumor control following i.t. IL-12 therapy in mice. bit.ly/3XmwCXQ @harvardmed.bsky.social
Giguelay and Maschmeyer et al. detected only minor differences in the PBMC immune cell composition of 17 cancer patients receiving ICI therapy, 8 with and 9 without severe neurological immune-related adverse events (n-irAEs). bit.ly/49MOC4X @leifludwig.bsky.social
November 13, 2025 at 4:45 PM
Giguelay and Maschmeyer et al. detected only minor differences in the PBMC immune cell composition of 17 cancer patients receiving ICI therapy, 8 with and 9 without severe neurological immune-related adverse events (n-irAEs). bit.ly/49MOC4X @leifludwig.bsky.social
Zhang et al employed cytotoxic B-elemene (ELE)-treated dying cancer cells (DCCs) as an immunogenic cell source within a sprayable fibrin hydrogel (with additional ELE). bit.ly/3JKRBk4
November 13, 2025 at 12:30 PM
Zhang et al employed cytotoxic B-elemene (ELE)-treated dying cancer cells (DCCs) as an immunogenic cell source within a sprayable fibrin hydrogel (with additional ELE). bit.ly/3JKRBk4
Gujar and Cui et al. recently developed N17350 – a cancer-specific therapeutic elastase t – and tested it in a wide range of preclinical models bit.ly/4p8h9GN
November 12, 2025 at 4:00 PM
Gujar and Cui et al. recently developed N17350 – a cancer-specific therapeutic elastase t – and tested it in a wide range of preclinical models bit.ly/4p8h9GN
Wang et al. generated αTIGIT-IL2, an immunocytokine comprising IL-2 and an anti-TIGIT scFv fused to a human IgG1Fc. bit.ly/3Lull4Z
November 11, 2025 at 12:30 PM
Wang et al. generated αTIGIT-IL2, an immunocytokine comprising IL-2 and an anti-TIGIT scFv fused to a human IgG1Fc. bit.ly/3Lull4Z
Khelil et al. demonstrated that SALL4 is overexpressed in multiple tumor types, including primary colorectal cancers and paired liver metastasis, but is silenced in almost all adult tissues. bit.ly/43dpgJD @gustaveroussy.fr
November 10, 2025 at 12:30 PM
Khelil et al. demonstrated that SALL4 is overexpressed in multiple tumor types, including primary colorectal cancers and paired liver metastasis, but is silenced in almost all adult tissues. bit.ly/43dpgJD @gustaveroussy.fr
Tan et al. reported clinical outcomes and translational analyses of patients with early-stage DNA mismatch repair-proficient colon cancer from the phase II NICHE trial. bit.ly/3LoDYHJ @myriamchalabi.bsky.social
November 7, 2025 at 4:45 PM
Tan et al. reported clinical outcomes and translational analyses of patients with early-stage DNA mismatch repair-proficient colon cancer from the phase II NICHE trial. bit.ly/3LoDYHJ @myriamchalabi.bsky.social
Compared to TCRs, CARs have poorer recruitment of proximal signaling molecules and antigen (Ag) sensitivity. bit.ly/3LgQLvQ @stanfordmedicine.bsky.social
November 7, 2025 at 12:45 PM
Compared to TCRs, CARs have poorer recruitment of proximal signaling molecules and antigen (Ag) sensitivity. bit.ly/3LgQLvQ @stanfordmedicine.bsky.social
Sasaki et al. addressed the toxicity of IL-12 that has caused dose-limiting immune-related adverse events (irAEs). bit.ly/43IbhM4 @ko1ssk.bsky.social
November 6, 2025 at 4:45 PM
Sasaki et al. addressed the toxicity of IL-12 that has caused dose-limiting immune-related adverse events (irAEs). bit.ly/43IbhM4 @ko1ssk.bsky.social
Takahashi et al. established a multi-site murine tumor model system for temporal tracking of CD8+ T cell phenotypes and clonal dynamics, identifying a “precursor exhausted” PD-1+Ly108+ population as a driver of clonal expansion. bit.ly/3JFFN2f
November 6, 2025 at 12:30 PM
Takahashi et al. established a multi-site murine tumor model system for temporal tracking of CD8+ T cell phenotypes and clonal dynamics, identifying a “precursor exhausted” PD-1+Ly108+ population as a driver of clonal expansion. bit.ly/3JFFN2f