Aaron Tan
@aarontan.bsky.social
Postdoctoral Research Fellow at SCELSE & SBS (Kline & Thibault Labs)
Research interests: Host-pathogen interactions, Extracellular Electron Transport
Personal interests: Photography, Cooking, Baking
Twitter: Photon_Trapper
Research interests: Host-pathogen interactions, Extracellular Electron Transport
Personal interests: Photography, Cooking, Baking
Twitter: Photon_Trapper
Reposted by Aaron Tan
Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.
doi.org
January 17, 2026 at 5:57 AM
Enterococcus fans: Check out our latest on E. faecalis EET, advancing our understanding of both the fundamental physiology of this bug and new mechanisms of its virulence. This is the product of a thrilling collaboration with friends in Singapore @gthibault.bsky.social led by @aarontan.bsky.social.
Reposted by Aaron Tan
Strep/Enterococcal colleagues!
Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up.
If you’re aiming for a short talk (lots of slots), registering early matters for full consideration.
Share widely!
www.grc.org/streptococca...
Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up.
If you’re aiming for a short talk (lots of slots), registering early matters for full consideration.
Share widely!
www.grc.org/streptococca...
2026 Streptococcal Biology Conference GRC
The 2026 Gordon Research Conference on Streptococcal Biology will be held in Lucca (Barga), Lucca Italy. Apply today to reserve your spot.
www.grc.org
January 21, 2026 at 11:48 AM
Strep/Enterococcal colleagues!
Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up.
If you’re aiming for a short talk (lots of slots), registering early matters for full consideration.
Share widely!
www.grc.org/streptococca...
Streptococcal Biology GRC/GRS are open for applications. Acceptances are underway and the meeting is on track to fill up.
If you’re aiming for a short talk (lots of slots), registering early matters for full consideration.
Share widely!
www.grc.org/streptococca...
Reposted by Aaron Tan
Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!
📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!
August 11, 2025 at 3:51 AM
Our latest efforts to understand Enterococcal wound infection. In long-term collaboration with @gthibault.bsky.social, we discovered how E. faecalis makes extracellular ROS - via EET!⚡️Which in turn dysregulates host UPR to delay wound healing. Led by @aarontan.bsky.social - his videos below are 🤩!