3Brain AG
3brainag.bsky.social
3Brain AG
@3brainag.bsky.social
We build sophisticated #cell-electronic interfaces to probe intelligent biological networks by linking them to software. #Drugdiscovery
𝗙𝗼𝗿𝗯𝗲𝗿𝗴𝗲𝗿, 𝗞𝗿𝗮𝗴𝗲𝗹𝘂𝗻𝗱 & 𝘁𝗵𝗲 𝗞𝗶𝗿𝘀𝗰𝗵𝘀𝘁𝗲𝗶𝗻 lab have developed a protocol which shows how to use CorePlate™ enabled 3D HD-MEAs (4,096 electrodes) to map how tumors disrupt brain networks. By tracking activity trajectories (CATs), they revealed lost functional connectivity in glioma models. #HDMEA #Cancer
February 12, 2026 at 9:44 AM
WORD 2026 - This year, we presented a scientific poster on CorePlate™ recordings of hippocampal organoids and their responses to various neuroactive compounds. A huge thank‑you to everyone who visited our booth, discussed their work, and shared new ideas!
#WORD2026 #BrainOrganoids #HDMEA #Ephys
February 11, 2026 at 8:47 AM
Meet us at the Science & Tech Expo on Feb 10 at the Alexandria Center, Stanford Research Park!

Discover how CorePlate™ HD‑MEAs enable deeper functional insights across neuronal & cardiac models. Plus free desserts, coffee & smoothies. Come say hi!
February 9, 2026 at 1:06 PM
New research from 𝗜𝗮𝗻𝗻𝗲𝗹𝗹𝗼 & 𝗖𝗶𝗮𝗺𝗽𝗶 (𝗔𝗺𝗮𝘁𝗼 group) shows how cultured neurons can be used for Biological Reservoir Computing. By encoding images into electrical patterns via HD-MEAs, they’ve enabled biological networks to perform pattern recognition. Check out the paper here: arxiv.org/abs/2510.05637
February 4, 2026 at 8:58 AM
How do we better model cholinergic pathways? By building human brain assembloids. Using CorePlate™ 3D electrodes, the 𝗟𝗶𝘂 𝗟𝗮𝗯 recorded high-res data from hnbM-cortical projections, even transplanting them into mice to establish human-derived pathways. #3Brain #iPSC #HDMEA #Organoids #Assembloids
January 29, 2026 at 9:10 AM
𝗭𝗮𝗽𝗳𝗲 et al. used CorePlate™ to track the center of mass of current in the hippocampus. It’s not just data, it’s a way to see hidden synaptic interactions in high-res. As a bonus, the current source density (CSD) graphics are stunning!

#Electrophysiology #HDMEA #Hippocampus #NeuralCircuits
January 22, 2026 at 9:58 AM
𝗠𝗶𝗰𝗿𝗼𝗴𝗹𝗶𝗮 𝗶𝗻 𝘁𝗵𝗲 𝗰𝗶𝗿𝗰𝘂𝗶𝘁!
𝗪𝘂 et al. show that adding human microglia to organoids and assembloids shapes circuit formation and activity, and that CorePlate™ HD-MEAs enabled them to reveal functional midbrain–striatal connectivity and hyperactivity in ASD-mutant assembloids.
January 20, 2026 at 8:58 AM
𝗪𝗵𝗲𝗻 𝗮𝗻 𝗜𝗺𝗺𝘂𝗻𝗲 𝗚𝗲𝗻𝗲 𝗥𝗲𝘄𝗿𝗶𝘁𝗲𝘀 𝗕𝗿𝗮𝗶𝗻 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁: 𝗗𝗲𝗺𝗲𝗻𝗲𝗴𝗼 et al. showed that hyperactive CXCR4 (linked to WHIM syndrome) disrupts cerebellar development and motor function, independent of infection. Using CorePlate™ HD-MEAs, researchers revealed circuit-level defects and a path to early intervention.
January 14, 2026 at 9:20 AM
How DNMT3A mutations reshape neural circuits. New work shows TBRS-associated DNMT3A mutations disrupt human cortical interneuron development, driving GABAergic hyperactivity and abnormal network bursting, revealed using CorePlate™ enabled HD-MEAs.

#Neuroscience #3Brain #Electrophysiology #HDMEA
January 8, 2026 at 12:55 PM
Reflecting on 2025, we are reminded that behind every data point is a dedicated researcher. From our MGA applicants to the energy of our global workshops, your passion is our inspiration. Thank you for your contributions to neuroscience. Wishing you rest, joy, and a Merry Christmas. buff.ly/NqmRcK4
3Brain 2025 Year-End Wrap Up
Reflecting on a year of innovation, connection, and discovery. To the researchers, applicants, and workshop attendees who made 2025 unforgettable: thank you. Your passion continues to be our greatest…
youtube.com
December 22, 2025 at 2:01 PM
A look back at the Assembloids & Complex Cell-Cell Interactions across Tissues & Organs meeting at CSHL. A fantastic conference exploring advances in assembloid research, with a workshop hosted by us to show how CorePlate™ enabled HD-MEA is helping functionally characterise assembloids.
December 16, 2025 at 1:33 PM
At CSHL Assembloids? Our workshop is today, 𝗗𝗲𝗰 𝟵𝘁𝗵 𝗮𝘁 𝟭𝟮:𝟯𝟬𝗽𝗺! Join us for live experiments, software demos, and hands-on tools to assess organoid and assembloid activity. Stop by our booth to connect or register online for this interactive session: www.3brain.com/events/cshl-25
December 9, 2025 at 10:53 AM
That’s a wrap on our “Recording Organoids with CorePlate™” workshop! From hands-on recordings in the Discovery Laboratory to BrainWave 6 analysis, the collaboration was inspiring. Huge thanks to all participants for the engagement—we are excited to see where your research goes next!
December 9, 2025 at 10:50 AM
𝗗𝗲𝗰𝗼𝗱𝗶𝗻𝗴 𝘁𝗵𝗲 𝗶𝗱𝗲𝗻𝘁𝗶𝘁𝗶𝗲𝘀 𝗼𝗳 𝗻𝗲𝘂𝗿𝗼𝗻𝘀 𝗮𝘁 𝘀𝗰𝗮𝗹𝗲
𝗚𝗶𝗿𝗮𝘂𝗱 𝗲𝘁 𝗮𝗹. show how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ HD-MEA recordings, combined with their 𝗦𝗽𝗶𝗸𝗲𝗠𝗔𝗣 pipeline, can identify neurons without prior labels, validated through viral and optogenetic methods. A remarkable advance for large-scale electrophysiology.
December 2, 2025 at 1:15 PM
Human striatal progenitors can rebuild broken brain circuits.
𝗦𝗰𝗮𝗿𝗮𝗺𝘂𝘇𝘇𝗮 et al. Recently showed that transplanted human striatal progenitors in an HD rodent model survive, differentiate, and integrate, with CorePlate™ HD-MEA recordings revealing some very interesting graft activity!
November 28, 2025 at 2:13 PM
Our “Recording Organoids with CorePlate™” workshop is now underway, and the energy from our participants has been fantastic. In our Discovery Laboratory, attendees have been exploring hands-on techniques for placing and recording brain organoids and have already found some amazing activity!
November 28, 2025 at 10:32 AM
Today marks the start of our “Recording Organoids with CorePlate™” workshop, where we’ll be hosting a series of sessions on the best ways to record and interpret activity from brain organoids. We’re excited to welcome our guests for a few packed days of learning, discovery, and fun together!
November 27, 2025 at 12:57 PM
What an incredible week at #SfN2025! Thank you to everyone who stopped by our booth, attended our Product Theatre, and visited our posters. We loved connecting with you, sharing our passion for electrophysiology and were thrilled to unveil our CorePlate™ enabled 96-well HD-MEA!
November 26, 2025 at 2:30 PM
Come and see the sneak preview of our new 96-well CorePlate™; precision-designed for advanced disease-in-a-dish modeling. This opens new possibilities for neuroscience and drug discovery. Get an exclusive look - be part of the breakthrough!

#SfN25
November 19, 2025 at 4:05 PM
Are you attending #SfN2025? Join us and 𝗦𝗧𝗘𝗠𝗖𝗘𝗟𝗟 𝗧𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀 at our product theatre! Discover how BrainPhys™ and our CorePlate™ HD-MEA with 3D electrodes unlock detailed functional insights from brain organoids. This powerful combination enhances drug discovery!
𝗣𝗿𝗼𝗱𝘂𝗰𝘁 𝗧𝗵𝗲𝗮𝘁𝗿𝗲: 𝗡𝗼𝘃 𝟭𝟳, 𝟭–𝟭:𝟯𝟬 𝗣𝗠
November 13, 2025 at 3:17 PM
Heading to #SfN2025? Come see how 3Brain’s CorePlate™ HD-MEA is transforming drug discovery at our product theatre with STEMCELL! Or visit our booth or poster!
Product Theatre (with STEMCELL): Nov 17, 1–1:30 PM
Booth #907
Poster: Nov 18, 2–3 PM
Let’s make brain research more connected than ever.
November 11, 2025 at 11:23 AM
𝗠𝗘𝗔-𝘀𝗲𝗾𝗫: 𝗕𝗿𝗶𝗱𝗴𝗶𝗻𝗴 𝗠𝗼𝗹𝗲𝗰𝘂𝗹𝗲𝘀 𝗮𝗻𝗱 𝗠𝗶𝗻𝗱
What if you could link the brain’s complex dialogue between genes and electrical activity? With the recent publication in Advanced Science by Emery et al. from the Hayder Amin group, this link is now a reality with MEA-seqX.
November 5, 2025 at 9:06 AM
Curious about the neural mechanisms behind deep brain stimulation (DBS)?
Prof. Kragelund will be sharing insights in a webinar about her high-density microelectrode array recordings, revealing how DBS modulates network connectivity and activity patterns in dystonia and glioma-associated epilepsy.
October 30, 2025 at 11:19 AM
𝗛𝗼𝘄 𝗮 𝘀𝗵𝗶𝗳𝘁 𝗶𝗻 𝗼𝗻𝗲 𝗴𝗲𝗻𝗲 𝗰𝗮𝗻 𝗿𝗲𝘄𝗿𝗶𝘁𝗲 𝘁𝗵𝗲 𝘀𝘁𝗼𝗿𝘆 𝗼𝗳 𝗯𝗿𝗮𝗶𝗻 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁

Thanks to 𝗠𝘂𝘀𝗮𝗻𝘁𝗲 et al. there are now two CRISPR iPSC neural lines carrying two CACNA1A mutations (F1491S and Y1854X). Want to know how 𝗖𝗼𝗿𝗲𝗣𝗹𝗮𝘁𝗲™ helped them determine the functional changes they found?
October 23, 2025 at 1:37 PM
Great data on brain organoids @ the 𝗘𝗠𝗕𝗢 | 𝗘𝗠𝗕𝗟 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱𝘀 𝗦𝘆𝗺𝗽𝗼𝘀𝗶𝘂𝗺! Hanna Dubrovska (DZNE Dean Lab) will present a poster using 𝟯𝗕𝗿𝗮𝗶𝗻 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝘆 to highlight differences in neuronal activity and plasticity between forebrain and hippocampal-like organoids.

𝗙𝗹𝗮𝘀𝗵 𝗧𝗮𝗹𝗸 𝗦𝗲𝘀𝘀𝗶𝗼𝗻 𝟭: 𝗧𝗼𝗱𝗮𝘆, 𝟭𝟱:𝟮𝟬–𝟭𝟱:𝟱𝟬
October 22, 2025 at 12:57 PM