Zepeng “Phoenix” Mu
@zpmu.bsky.social
Postdoc working on immunogenomics and CRISPR in Boston.
Reposted by Zepeng “Phoenix” Mu
So excited to share our latest study on defining the function of disease variants by editing single cells, and assuming them with CRAFT-seq! Special thanks to @zpmu.bsky.social and @baglaenkolab.bsky.social! @broadinstitute.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Precisely defining disease variant effects in CRISPR-edited single cells - Nature
A plate-based assay called CRAFTseq has been developed that uses ‘multi-omic’ single-cell RNA sequencing and direct genotyping of CRISPR edits to test the functional effects of genetic variants o...
www.nature.com
July 23, 2025 at 11:34 PM
So excited to share our latest study on defining the function of disease variants by editing single cells, and assuming them with CRAFT-seq! Special thanks to @zpmu.bsky.social and @baglaenkolab.bsky.social! @broadinstitute.org
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Zepeng “Phoenix” Mu
📣Excited to share my last postdoc paper with
@soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social
TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵
@soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social
TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵
February 27, 2025 at 2:21 AM
📣Excited to share my last postdoc paper with
@soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social
TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵
@soumya-boston.bsky.social on eQTL mechanisms depending on where the RNA is in the cell! @broadinstitute.org @harvardmed.bsky.social
TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵
First Bluesky post! Excited to share the final chapter of my PhD research! We performed a large- scale and thorough scATAC QTL analysis in PBMC, and gained insight on how caQTL can help us better understand disease GWAS and inform future study design.
Impact of disease-associated chromatin accessibility QTLs across immune cell types and contexts https://www.medrxiv.org/content/10.1101/2024.12.05.24318552v1
December 14, 2024 at 2:33 PM
First Bluesky post! Excited to share the final chapter of my PhD research! We performed a large- scale and thorough scATAC QTL analysis in PBMC, and gained insight on how caQTL can help us better understand disease GWAS and inform future study design.