I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...

‼️ Excited to share our new paper out now in @science.org ‼️

We describe a new tetrameric RAD51 paralog complex – XRCC3-RAD51C-RAD51D-XRCC2 – which caps the end of RAD51 filaments.

Link: www.science.org/doi/epdf/10....

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New review out on molecular glues: turning serendipitous hits into smartly designed drugs that tag cancer-linked proteins for destruction 🧬💥💊
www.tandfonline.com/doi/full/10....

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

A photo from the recombination mechanisms conference in Crete last week. Thanks to the @fusionconf.bsky.social team, speakers, poster presenters and attendees for a great meeting!

Update on #Recombination25 Conference! 🚨
📅RD & PS Deadline: 13th March 2025. DON'T MISS OUT!
🌟Grants are available for students, postdocs & junior investigators!🌟
For more details, visit bit.ly/41v8IuK or email Felicity at 📧[email protected]
@westlabcrick.bsky.social

Talk submission deadline coming up on 10th February 2025!

The West lab @crick.ac.uk has finally joined bluesky! Looking forward to sharing (and discovering!) new work 🧬 #recombination #dnarepair #BRCA #cryoEM #cellbiology