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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 23h

The team was able to demonstrate that zalsupindole promotes neuroplasticity similarly to ketamine, DMT, and psilocybin without the hallucinogenic effects. Stay tuned for more updates as this compound progresses through the clinical trial process.

Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 23h

Read the latest research from Delix on #zalsupindole, a compound invented at the #UCDavisIPN by director @deolsonlab.bsky.social and his team. Zalsupindole, is a non-dissociative, non-hallucinogenic #psychedelic analogue, and is the first neuroplastogen to be administered to patients with MDD!

Zalsupindole is a Nondissociative, Nonhallucinogenic Neuroplastogen with Therapeutic Effects Comparable to Ketamine and Psychedelics

Many neuropsychiatric conditions, including depression, involve synaptic loss and atrophy of the prefrontal cortex. The rapid regrowth of cortical neurons has been hypothesized to explain the rapid an...

pubs.acs.org

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 12d

Behavioral changes appeared, but endogenous psychedelic levels remained largely unchanged suggesting alternative biosynthetic pathways at work.

This study opens the door to new questions about how the body might naturally produce psychedelic compounds.

Read the full study:

Indolethylamine N-Methyltransferase Deletion Impacts Mouse Behavior without Disrupting Endogenous Psychedelic Tryptamine Production

Exogenously administered psychedelics produce both rapid and long-lasting effects on neuroplasticity and behavior, but it is currently unclear if endogenously produced psychedelics can elicit similar ...

pubs.acs.org

Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 12d

#UCDavisIPN Director @deolsonlab.bsky.social and his team studied mice without INMT, an enzyme long thought to be essential for producing endogenous #psychedelics like DMT. The surprise...?

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 14d

In a new publication from #UCDavisIPN affiliate Danielle Stolzenberg, her team found that postpartum mice given psilocybin showed a long-term increase in anxiety behaviors after a single dose. Even more striking, their offspring experienced similar effects.

Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring - Nature Communications

The treatment potential of psilocybin for postpartum depression was investigated in a preclinical mouse model. Here the authors show both acute and long-term effects of psilocybin in mothers and their offspring who were exposed via lactation.

www.nature.com

Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 20d

Researchers @umich.edu found #psychedelics can boost brain connections even when neurons don’t have the usual 5-HT2A receptor because nearby cells pass the effect along. At #UCDavisIPN, we’re also exploring surprising ways psychedelics reshape the brain.

Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors - Molecular Psychiatry

Molecular Psychiatry - Psychedelic neuroplasticity of cortical neurons lacking 5-HT2A receptors

www.nature.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · 25d

Interested in reading more about the IPN? Join our newsletter! We publish each Spring and Fall. We share about our research of course, but you can also get an inside look at what we're all about here at the #UCDavisIPN. Sign up here:

UC Davis Institute for Psychedelics & Neurotherapeutics Newsletter

Sign up for our newsletter:

docs.google.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Sep 10

There’s still plenty to uncover, and an ongoing collaboration with #UCDavisIPN’s own @deolsonlab.bsky.social will be key to understanding the mechanisms at play and which compound might offer the greatest benefit with the fewest side effects.

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Sep 10

IPN collaborator Dr. Uri Manor at
@ucsandiego.bsky.social reveals that #psychedelics as well as non-hallucinogenic analogues developed at the #UCDavisIPN can grow new synapses in the cochlea of mice which could open new horizons for treating age-related hearing loss.

Scientists find psychedelics stimulate the growth of new synapses in the ear

Scientists are exploring the possibilities

spectrumnews1.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Sep 9

At #UCDavisIPN we’re pursuing similar goals researching LSD analogues like JRT that boost neuroplasticity without hallucinations, a promising path towards addressing unmet needs in neuropsychiatric treatment. #psychedelic

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Sep 9

New in @jama.com: A phase 2b trial of an oral LSD formulation (MM120) found that 100 µg and 200 µg doses significantly reduced anxiety symptoms in adults with generalized anxiety disorder. Results support 100 µg as the optimal dose for future trials.

Single Treatment With MM120 (Lysergide) in Generalized Anxiety Disorder

This randomized clinical trial assesses the dose-response relationship of MM120 (lysergide D-tartrate) vs placebo in adults with moderate to severe generalized anxiety disorder.

jamanetwork.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Aug 18

#UCDavisIPN affiliate Danielle Stolzenberg, commented on the trial for the @sfchronicle.com: "It’s very encouraging to see PPD represented in the new wave of psychedelic research," though, she shares, "It’s unclear whether psychedelics will be safe during the postpartum period.”

This unorthodox treatment could help new moms: ‘The tipping point is coming’

Demand is surging among new moms for this once-taboo treatment, and the first trials of a new drug have shown promising results.

www.sfchronicle.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Aug 18

Reunion Neuroscience has achieved positive topline results from the Phase 2 trial of RE104, a synthetic #psychedelic, in postpartum depression. This marks an exciting milestone for their mission. Remarkably, 71% of patients experienced remission of symptoms within 7 days.

Reunion Neuroscience Announces Positive Topline Results from RECONNECT Phase 2 Clinical Trial of RE104 for the Treatment of Postpartum Depression (PPD)

-- Achieved Primary Endpoint with 30mg Dose of RE104 Demonstrating 23.0-Point Reduction from Baseline in Montgomery-Åsberg Depression Rating Scale (MADRS)...

www.globenewswire.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Aug 6

On @npr.org’s The Sunday Story, IPN Director, @deolsonlab.bsky.social explains how #psychedelics may treat depression by promoting brain plasticity and why he’s working to engineer out the trip.

🎧 Hear more on the psychedelic renaissance and where science is headed:

Can Psychedelic Therapy Go Mainstream? : Up First from NPR

Research shows that psychedelics can help with a range of mental health conditions, like PTSD and depression. So why can't you get them from your doctor? Today on The Sunday Story, we take a trip thro...

www.npr.org

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Aug 5

Greg Watry of @ucdlands.bsky.social wrote a wonderful article about the #UCDavisIPN's @natureportfolio.nature.com most recent Neuroscience publication. Find out why our associate director, John A. Gray said, "Science is full of surprises."

Read the article here: www.ucdavis.edu/news/psyched...

Psychedelics and Non-hallucinogenic Analogs Work Through the Same Receptor, Up to a Point

Understanding exactly how psychedelics promote new connections in the brain is critical to developing targeted, non-hallucinogenic therapeutics that can treat neurodegenerative and neuropsychiatric di...

www.ucdavis.edu

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Aug 4

The field of psychedelic science is finally closer to an answer on how non-hallucinogenic psychedelic analogues induce neuroplasticity. Read the new publication from the #UCDavisIPN in @natureportfolio.nature.com Neuroscience about how the team uncovered this using TBG, lasers, and genetic tools.

The psychoplastogen tabernanthalog induces neuroplasticity without proximate immediate early gene activation - Nature Neuroscience

Aarrestad et al. show that, in contrast to psychedelics, the nonhallucinogenic psychoplastogen tabernanthalog promotes neuroplasticity through 5-HT2AR activation without immediately increasing extrace...

www.nature.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Jul 22

#UCDavisIPN Director @deolsonlab.bsky.social spoke with Lisa Wexler from the Voice of Connecticut about JRT, a non-hallucinogenic #psychedelic analogue with potential to treat schizophrenia.

🔗 Listen to David's segment on The Lisa Wexler Show here or anywhere you get your podcasts:

A New Drug Could Revolutionize Treating Mental Health | The Lisa Wexler Show

shows.acast.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Jul 21

A team led by @zenbrainest.bsky.social and colleagues screened 41 classical #psychedelics across 318 human receptors. The result? A sweeping map of psychedelic polypharmacology that includes broad activity at serotonin, dopamine, and adrenergic receptors.

🔗 Read the full study:

The polypharmacology of psychedelics reveals multiple targets for potential therapeutics

Jain et al. profiled 41 classical psychedelics across 318 GPCRs, revealing activity at serotonin, dopamine, and adrenergic receptors. All compounds activated multiple 5-HT2AR signal transduction pathw...

www.cell.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Jun 24

Big news in #psychedelic science: Compass Pathways' proprietary psilocybin formulation is the first-ever classic psychedelic in a Phase 3 trial. It showed a significant reduction in depression symptoms compared to placebo. We’re very excited to see the data once published!

Read the press release:

Compass Pathways Successfully Achieves Primary Endpoint in First Phase 3 Trial Evaluating COMP360 Psilocybin for Treatment-Resistant Depression

Compass Pathways plc (Nasdaq: CMPS), a biotechnology company dedicated to accelerating patient access to evidence-based innovation, announced today the succe...

www.businesswire.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · Jun 16

#UCDavisIPN Affiliate @sadeghlab.bsky.social co-authored a new @natureportfolio.nature.com paper revealing how maternal exposure to 5-HT2C agonists can cause the choroid plexus to secrete proteins into cerebrospinal fluid, affecting fetal brain development and behavior into adulthood. Read more:

Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development - PubMed

The choroid plexus (ChP) regulates cerebrospinal fluid (CSF) composition, providing essential molecular cues for brain development; yet, embryonic ChP secretory mechanisms remain poorly defined. Here ...

pubmed.ncbi.nlm.nih.gov

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · May 23

Meet us at the Davis Public Library in Davis on May 29th for IPN Affiliate @manvir.bsky.social's author talk on "Shamanism: The Timeless Religion." Register for the event, hosted by the Avid Reader, using the link below.

Where: 315 E. 14th Street, Davis, CA 95616
Time: 6:30PM
#shamanism #UCDavisIPN

Manvir Singh @ The Yolo County Library

Davis' Local Independent Bookstore since 1987

avidreaderbooks.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · May 20

Now available: Shamanism: The Timeless Religion written by IPN Affiliate @manvir.bsky.social. Manvir's work cuts through myths and binaries, exploring the deeper meaning behind our fascination with shamanism and ancient ways of knowing.

Order your copy now:

#UCDavisIPN #shamanism

Shamanism by Manvir Singh: 9780593537541 | PenguinRandomHouse.com: Books

From a brilliant, young, Harvard-trained anthropologist and contributor to The New Yorker comes a fascinating investigation into the spiritual practice of shamanism, from its beginnings to the present...

www.penguinrandomhouse.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · May 16

Whether you're curious about the life of an anthropologist doing remote fieldwork or how the global archaic psychedelic shamanism hypothesis misrepresents reality, this book is a must-read. Preorder your copy now at the link below:

@aaknopf.bsky.social

#UCDavisIPN #shamanism #psychedelics

Shamanism by Manvir Singh: 9780593537541 | PenguinRandomHouse.com: Books

From a brilliant, young, Harvard-trained anthropologist and contributor to The New Yorker comes a fascinating investigation into the spiritual practice of shamanism, from its beginnings to the present...

www.penguinrandomhouse.com

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · May 16

IPN Affiliate @manvir.bsky.social's new book "Shamanism: The Timeless Religion" releases May 20th. The book is a provocative journey through history, belief, and the incredible diversity of human spiritual and healing practices.

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Institute for Psychedelics and Neurotherapeutics @ucdavisipn.bsky.social · May 7

Thanks to NIH Research Matters team for recognizing the #UCDavisIPN's work on JRT. This work brings us closer to creating effective and practical treatments for patients.

An LSD analogue for treating psychiatric diseases

Researchers designed a non-hallucinogenic analogue of LSD that had antidepressant and numerous cognitive benefits in mice.

www.nih.gov

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