Tommy Vierbuchen
@tvierbuchen.bsky.social
Assistant Professor, Developmental Biology, Center for Stem Cell Biology at Sloan Kettering. Building next generation stem cell models to study genetics of brain development.
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
https://www.mskcc.org/research/ski/labs/thomas-vierbuchen
Pinned
Tommy Vierbuchen
@tvierbuchen.bsky.social
· Aug 27
A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro: Developmental Cell www.cell.com/developmenta...
Reposted by Tommy Vierbuchen
I know Americans overly romanticize Europe but I still think moving to a little house on a canal in the Netherlands could solve like 82% of my problems
December 9, 2025 at 2:23 AM
I know Americans overly romanticize Europe but I still think moving to a little house on a canal in the Netherlands could solve like 82% of my problems
Reposted by Tommy Vierbuchen
NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US:
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
SeminarPage | Carlo Colantuoni
carlocolantuoni.org
December 9, 2025 at 4:21 PM
NEXT TUE: DDD seminar, Dec. 16, 2025 @ 1PM Eastern US:
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Dr. Tommy Vierbuchen @tvierbuchen.bsky.social will share his recent work on on cell villages using outbred mice: "A pluripotent stem cell platform for in vitro systems genetics studies of mouse brain development". carlocolantuoni.org/seminar
Reposted by Tommy Vierbuchen
📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social!
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
December 8, 2025 at 9:13 PM
📢 You won't want to miss our next episode with Dr. @hansclevers.bsky.social!
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Learn about his return to the @hubrechtinstitute.bsky.social and his experience running the Institute of Human Biology at Roche: https://bit.ly/48sIRIV
Reposted by Tommy Vierbuchen
Redundancy masks functional specificity of SMARCD paralogs in neurodevelopment https://www.biorxiv.org/content/10.64898/2025.12.05.692564v1
December 8, 2025 at 2:16 AM
Redundancy masks functional specificity of SMARCD paralogs in neurodevelopment https://www.biorxiv.org/content/10.64898/2025.12.05.692564v1
Reposted by Tommy Vierbuchen
TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque:
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
December 7, 2025 at 5:17 PM
TIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque:
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
"This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
Reposted by Tommy Vierbuchen
Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...
Molecular basis for de novo thymus regeneration in a vertebrate, the axolotl
The molecular, cellular, and functional restoration of the axolotl thymus after de novo regeneration is described.
www.science.org
December 5, 2025 at 7:47 PM
Very happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...
Reposted by Tommy Vierbuchen
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
December 3, 2025 at 6:53 PM
We are excited to share our new preprint:
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids.
www.biorxiv.org/content/10.64898/2025.12.01.691499v1
Reposted by Tommy Vierbuchen
High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/
High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape
Helmy et al. provide a collection of high-quality mouse reference genomes. They were
able to resolve some of the most complex regions among mouse genomes that are involved
in immune defense. These fin...
www.cell.com
December 2, 2025 at 4:30 AM
High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/
Last bit of fall still hanging on in Central Park
December 1, 2025 at 3:17 AM
Last bit of fall still hanging on in Central Park
Reposted by Tommy Vierbuchen
Don't miss this episode!
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
November 26, 2025 at 1:01 AM
Don't miss this episode!
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social discusses his work direct reprogramming #fibroblasts into neurons, and PSC models of #neurodevelopment.
Check it out: https://bit.ly/48dmghX
Reposted by Tommy Vierbuchen
Now live, and thanks to @erictopol.bsky.social for organising this!
Matthew Cobb (@matthewcobb2)
This was a terrific discussion with Eric about my new biography of Francis Crick.
substack.com
November 25, 2025 at 8:42 PM
Now live, and thanks to @erictopol.bsky.social for organising this!
Reposted by Tommy Vierbuchen
New work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Motif-based models accurately predict cell type-specific distal regulatory elements - Nature Communications
Decoding cell identity from DNA alone is a challenge. Here, the authors demonstrate that counting transcription factor motifs in regulatory DNA can forecast cell-type specificity outperforming deep-le...
www.nature.com
November 25, 2025 at 3:54 AM
New work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
November 24, 2025 at 11:34 PM
Our next episode features Dr. @tvierbuchen.bsky.social from @mskcancercenter.bsky.social
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Tune in tomorrow to hear about his work on next-generation models of #BrainDevelopment. 🧠
Reposted by Tommy Vierbuchen
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 21, 2025 at 10:34 PM
I wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
Reposted by Tommy Vierbuchen
Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium https://www.biorxiv.org/content/10.1101/2025.11.18.689013v1
November 18, 2025 at 9:32 PM
Unified Generation of Regionalized Neural Organoids from Single-Lumen Neuroepithelium https://www.biorxiv.org/content/10.1101/2025.11.18.689013v1
Reposted by Tommy Vierbuchen
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
www.biorxiv.org
November 18, 2025 at 2:51 PM
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Reposted by Tommy Vierbuchen
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
November 13, 2025 at 4:00 PM
The link between the gut #microbiome and autism is not backed by science, researchers say.
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA
@wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
Reposted by Tommy Vierbuchen
There’s a terrific review of CRICK in @science.org tonight, thanks to @adrianwoolfson.bsky.social. The PDF isn’t working right now; I’ll post a screenshot later. Here’s the paywalled html link:
Francis Crick’s life and legacy
A new biography offers a definitive account of the DNA decoder
www.science.org
November 13, 2025 at 8:13 PM
There’s a terrific review of CRICK in @science.org tonight, thanks to @adrianwoolfson.bsky.social. The PDF isn’t working right now; I’ll post a screenshot later. Here’s the paywalled html link:
Reposted by Tommy Vierbuchen
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
November 10, 2025 at 9:46 PM
We're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
Reposted by Tommy Vierbuchen
Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds https://www.biorxiv.org/content/10.1101/2025.11.08.687374v1
November 10, 2025 at 3:30 AM
Gene editing in "cell villages" enables exploring disease-relevant mutations in many genetic backgrounds https://www.biorxiv.org/content/10.1101/2025.11.08.687374v1
Reposted by Tommy Vierbuchen
In the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics
Listen here: www.activemotif.com/podcasts-rya...
Listen here: www.activemotif.com/podcasts-rya...
October 20, 2025 at 7:01 AM
In the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics
Listen here: www.activemotif.com/podcasts-rya...
Listen here: www.activemotif.com/podcasts-rya...
Reposted by Tommy Vierbuchen
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Conservation and alteration of mammalian striatal interneurons - Nature
An analysis of cell-type diversity in brain samples from a variety of mammalian species, both during development and in adult animals, reveals that the TAC3 initial class of striatal interneurons is c...
www.nature.com
November 7, 2025 at 6:06 PM
Our new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
Reposted by Tommy Vierbuchen
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
ZMYND11 Restrains KMT2A to Enable a Neuronal Developmental Program
Mutations in the chromatin reader and tumor suppressor ZMYND11 are the cause of ZMYND11-related syndromic intellectual disability (ZRSID), a disorder characterized by symptoms such as language and mot...
www.biorxiv.org
November 4, 2025 at 11:37 PM
Very pleased to share this work from my time as a graduate student with the Greenberg lab. We investigate the molecular function of ZMYND11, a tumor suppressor and chromatin reader which is also a cause of syndromic intellectual disability. Preprint available now: www.biorxiv.org/content/10.1...
Reposted by Tommy Vierbuchen
Oocyte-like mouse cells made from stem cells even without the guiding signals from ovarian cells. Another step towards in vitro gametes.
www.cell.com/developmenta...
www.cell.com/developmenta...
In vitro oogenesis breaks free of the ovary
In this issue of Developmental Cell, Nosaka et al. differentiate mouse pluripotent
stem cells to large germinal vesicle-stage oocyte-like cells in the absence of ovarian
somatic cells. Their paradigm ...
www.cell.com
November 3, 2025 at 7:54 PM
Oocyte-like mouse cells made from stem cells even without the guiding signals from ovarian cells. Another step towards in vitro gametes.
www.cell.com/developmenta...
www.cell.com/developmenta...