Cardiovascular Diseases Research Institute
@tumscvdri.bsky.social
Tehran Heart Center | Tehran University of Medical Sciences
Cardiovascular research & education to enhance heart health
Follow us on X: @TUMS_CVDRI
#Cardiology | #THC | #TUMS
Cardiovascular research & education to enhance heart health
Follow us on X: @TUMS_CVDRI
#Cardiology | #THC | #TUMS
Can #Eptifibatide change the game for #NSTEMI patients? Our 5-year study at Tehran Heart Center (n=5309) found no significant impact on MACE (17.2% vs. 15.6%) or survival (HR 0.97, p=0.901) post-PCI. Time for targeted trials in high-risk groups? onlinelibrary.wiley.com/doi/10.1002/...
Can Eptifibatide Rewrite the NSTEMI Story? (Eptifibatide vs. Standard Care for NSTEMI: A 5‐Year Analysis of Major Adverse Cardiovascular Events)
Background
Coronary artery disease (CAD) is a leading cause of death worldwide. Among acute coronary syndromes, non-ST-elevation myocardial infarction (NSTEMI) poses a higher long-term risk than ST-.....
onlinelibrary.wiley.com
November 29, 2025 at 6:27 AM
Can #Eptifibatide change the game for #NSTEMI patients? Our 5-year study at Tehran Heart Center (n=5309) found no significant impact on MACE (17.2% vs. 15.6%) or survival (HR 0.97, p=0.901) post-PCI. Time for targeted trials in high-risk groups? onlinelibrary.wiley.com/doi/10.1002/...
Developed valid tools based on the Theory of Planned Behavior to assess determinants of nutritional behavior in patients with #HeartFailure. These reliable instruments enable targeted education and intervention design. #Nutrition #TPB #Psychometrics publish.kne-publishing.com/index.php/JT...
Development and Validation of a Tool to Assess Determinants of Nutritional Behavior in Patients with Heart Failure Based on the Theory of Planned Behavior
| The Journal of Tehran University ...
publish.kne-publishing.com
November 27, 2025 at 7:00 AM
Developed valid tools based on the Theory of Planned Behavior to assess determinants of nutritional behavior in patients with #HeartFailure. These reliable instruments enable targeted education and intervention design. #Nutrition #TPB #Psychometrics publish.kne-publishing.com/index.php/JT...
#COVID19 #vaccination in men with benign prostatic hyperplasia may slightly worsen urgency, dysuria, frequency, and #hematuria, without changing prostate-specific antigen or prostate volume. #BPH ecevr.org/DOIx.php?id=...
November 26, 2025 at 5:30 AM
#COVID19 #vaccination in men with benign prostatic hyperplasia may slightly worsen urgency, dysuria, frequency, and #hematuria, without changing prostate-specific antigen or prostate volume. #BPH ecevr.org/DOIx.php?id=...
Reposted by Cardiovascular Diseases Research Institute
The Lancet Global Health released new global estimates showing a dramatic rise in #Sepsis burden and the reversing trends after decades of progress. Published Oct 21, 2025 #sepsiscanada #sepsiskills #MedSky
Read the full article here: www.thelancet.com/journals/lan...
Read the full article here: www.thelancet.com/journals/lan...
November 11, 2025 at 1:14 AM
The Lancet Global Health released new global estimates showing a dramatic rise in #Sepsis burden and the reversing trends after decades of progress. Published Oct 21, 2025 #sepsiscanada #sepsiskills #MedSky
Read the full article here: www.thelancet.com/journals/lan...
Read the full article here: www.thelancet.com/journals/lan...
Among 1,044 valve replacement patients, 4.3% died mid-term. Older age and female gender independently predicted mortality—highlighting the need for better preoperative risk assessment. #ValveSurgery #MortalityPredictors onlinelibrary.wiley.com/doi/10.1002/...
Mid‐Term Clinical Outcomes and Predictors of Mortality and Major Adverse Cardiovascular Events Following Cardiac Valve Replacement Surgery: A Retrospective Cohort Study From a Tertiary Center in Iran
Objectives
Valvular heart disease (VHD) is a growing global health concern with increasing prevalence, particularly in aging populations. While surgical valve replacement (VRS) remains a definitive .....
onlinelibrary.wiley.com
November 17, 2025 at 5:57 AM
Among 1,044 valve replacement patients, 4.3% died mid-term. Older age and female gender independently predicted mortality—highlighting the need for better preoperative risk assessment. #ValveSurgery #MortalityPredictors onlinelibrary.wiley.com/doi/10.1002/...
A rare massive left atrial #myxoma in an elderly man, first mistaken for hypoglycemia, reveals how hidden cardiac sources can underlie #stroke. Early #echocardiography is crucial. #CaseReport cardiothoracicsurgery.biomedcentral.com/articles/10....
Massive left atrial myxoma uncommon presentation in an aged Man, an educational case report and literature review - Journal of Cardiothoracic Surgery
Background Cardiac myxomas are the most common primary tumors of the heart, although they remain rare overall, particularly in elderly male patients. Left atrial myxomas typically present with nonspec...
cardiothoracicsurgery.biomedcentral.com
November 15, 2025 at 5:43 AM
A rare massive left atrial #myxoma in an elderly man, first mistaken for hypoglycemia, reveals how hidden cardiac sources can underlie #stroke. Early #echocardiography is crucial. #CaseReport cardiothoracicsurgery.biomedcentral.com/articles/10....
#MachineLearning predicts 1-year #MACE after #PCI in #elderly #STEMI patients. RF and XGBoost achieve AUC ~0.95; top predictors include ejection fraction, age, creatinine, glucose, BMI, and LDL/HDL ratio. Toward personalized post-PCI care. bmcmedinformdecismak.biomedcentral.com/articles/10....
Applied machine learning to predict 1-year major adverse cardiovascular events in elderly patients after percutaneous coronary intervention - BMC Medical Informatics and Decision Making
Cardiovascular diseases remain the leading cause of mortality worldwide, with elderly patients experiencing the worst prognosis following ST-elevation myocardial infarction (STEMI). Traditional risk s...
bmcmedinformdecismak.biomedcentral.com
November 13, 2025 at 6:19 AM
#MachineLearning predicts 1-year #MACE after #PCI in #elderly #STEMI patients. RF and XGBoost achieve AUC ~0.95; top predictors include ejection fraction, age, creatinine, glucose, BMI, and LDL/HDL ratio. Toward personalized post-PCI care. bmcmedinformdecismak.biomedcentral.com/articles/10....
#MetaAnalysis (>1.5M individuals) shows 1 in 4 #IBD patients have NAFLD—higher in adults, males, and Western regions.
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Prevalence and Associated Factors of Nonalcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease: An Updated Global Systematic Review and Meta-Analysis of over 1.5 Million Individuals
AbstractBackground. Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent chronic liver condition worldwide, with its burden increasingly
academic.oup.com
November 10, 2025 at 5:38 AM
#MetaAnalysis (>1.5M individuals) shows 1 in 4 #IBD patients have NAFLD—higher in adults, males, and Western regions.
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
Highlights need for routine liver screening in IBD management. #epidemiology #prevalence academic.oup.com/ibdjournal/a...
On-pump #CABG alters key hemodynamic and biochemical markers. Gender and comorbidities significantly impact cerebral oximetry and PaO₂. #BP #Comorbidity #Surgery pubmed.ncbi.nlm.nih.gov/41179702/#:~...
Assessing hemodynamic changes before and after pump in CABG surgery and its factors - PubMed
The clinical and para-clinical status in patients undergoing CABG surgery changes after on-pump surgery. In addition, comorbidities of patients have a positive and significant effect on PaO₂, as well as gender, on cerebral oximetry, hemoglobin, and hematocrit values.
pubmed.ncbi.nlm.nih.gov
November 6, 2025 at 7:27 AM
On-pump #CABG alters key hemodynamic and biochemical markers. Gender and comorbidities significantly impact cerebral oximetry and PaO₂. #BP #Comorbidity #Surgery pubmed.ncbi.nlm.nih.gov/41179702/#:~...
A migrated #IVC filter with severe #CAD — a rare surgical challenge.
Successful combined retrieval and #CABG for LAD stenosis proved the power of teamwork. #Cardiology #Surgery #CaseReport
cardiothoracicsurgery.biomedcentral.com/articles/10....
Successful combined retrieval and #CABG for LAD stenosis proved the power of teamwork. #Cardiology #Surgery #CaseReport
cardiothoracicsurgery.biomedcentral.com/articles/10....
Intracardiopulmonary migration of an inferior vena cava filter and concurrent coronary artery disease: a rare surgical challenge - Journal of Cardiothoracic Surgery
Introduction Inferior vena cava (IVC) filters are widely used to prevent pulmonary embolism (PE), particularly in patients with contraindications to anticoagulation or those experiencing recurrent thr...
cardiothoracicsurgery.biomedcentral.com
November 4, 2025 at 10:33 AM
A migrated #IVC filter with severe #CAD — a rare surgical challenge.
Successful combined retrieval and #CABG for LAD stenosis proved the power of teamwork. #Cardiology #Surgery #CaseReport
cardiothoracicsurgery.biomedcentral.com/articles/10....
Successful combined retrieval and #CABG for LAD stenosis proved the power of teamwork. #Cardiology #Surgery #CaseReport
cardiothoracicsurgery.biomedcentral.com/articles/10....
#MetaAnalysis of 158 studies: #BiologicalValves fail more over time; mechanical ones need fewer reoperations but cause more thrombosis. Mortality low for both. #CHD #PVR link.springer.com/article/10.1....
Long-Term Outcomes and Complications of Pulmonary Valve Replacement: A Meta-Analysis of Mechanical Versus Biological Prostheses - Pediatric Cardiology
This meta-analysis exclusively examines pulmonary valve replacement (PVR) outcomes in congenital heart disease (CHD) patients. CHD affects nearly 1% of live births globally, with a significant subset ...
link.springer.com
November 1, 2025 at 8:11 AM
#MetaAnalysis of 158 studies: #BiologicalValves fail more over time; mechanical ones need fewer reoperations but cause more thrombosis. Mortality low for both. #CHD #PVR link.springer.com/article/10.1....
Higher Systemic Immune-Inflammation Index is associated with non-alcoholic fatty liver disease; Hedge’s g = 0.11 and odds ratio (OR) = 1.45. Further longitudinal studies are needed. #NAFLD #SII #SystemicInflammation #Biomarker #MetaAnalysis journals.lww.com/annals-of-me...
October 30, 2025 at 5:19 AM
Higher Systemic Immune-Inflammation Index is associated with non-alcoholic fatty liver disease; Hedge’s g = 0.11 and odds ratio (OR) = 1.45. Further longitudinal studies are needed. #NAFLD #SII #SystemicInflammation #Biomarker #MetaAnalysis journals.lww.com/annals-of-me...
#Loneliness may boost #self-care among #elderly with chronic kidney disease, as shown by a structural equation model explaining over 80% of variance. This challenges traditional views and highlights the need for nuanced psychological interventions. bmcpublichealth.biomedcentral.com/articles/10....
Association between loneliness and self-care in elderly individuals with chronic kidney disease: a structural equation modeling approach - BMC Public Health
Chronic kidney disease (CKD) presents a growing global challenge among aging populations. Effective self-care remains a cornerstone of disease management in elderly patients. This study investigated t...
bmcpublichealth.biomedcentral.com
October 28, 2025 at 6:44 AM
#Loneliness may boost #self-care among #elderly with chronic kidney disease, as shown by a structural equation model explaining over 80% of variance. This challenges traditional views and highlights the need for nuanced psychological interventions. bmcpublichealth.biomedcentral.com/articles/10....
Dynapenic obesity—defined by either #BMI or waist circumference—significantly increases all-cause mortality risk (HR up to 1.73).
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Dynapenic obesity and all-Cause mortality: A systematic review and Meta-analysis of prospective cohort studies - Aging Clinical and Experimental Research
Background Dynapenia and obesity have been independently shown to be associated with an increased risk of all-cause mortality. However, the association between dynapenic obesity [defined by waist circ...
link.springer.com
October 27, 2025 at 5:52 AM
Dynapenic obesity—defined by either #BMI or waist circumference—significantly increases all-cause mortality risk (HR up to 1.73).
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Our findings highlight the compounded impact of muscle weakness and #obesity on long-term survival. #MuscleStrength #MetaAnalysis link.springer.com/article/10.1...
Metabolic syndrome affects 2 in 3 Iranians with #diabetes—rising from 60% to 67% (2015–2021). Strongly tied to CVD and diabetic complications, it calls for urgent, nation‑wide prevention and lifestyle action. #PublicHealth bmcendocrdisord.biomedcentral.com/articles/10.....
Trends of metabolic syndrome among Iranian patients with diabetes and its association with cardiovascular disease and diabetes complications: a nationwide study of the National Program for Prevention ...
Background Metabolic syndrome (MetS) is highly prevalent among individuals with type 2 diabetes and is characterized by a combination of specific clinical parameters including abnormal blood lipid lev...
bmcendocrdisord.biomedcentral.com
October 26, 2025 at 10:03 AM
Metabolic syndrome affects 2 in 3 Iranians with #diabetes—rising from 60% to 67% (2015–2021). Strongly tied to CVD and diabetic complications, it calls for urgent, nation‑wide prevention and lifestyle action. #PublicHealth bmcendocrdisord.biomedcentral.com/articles/10.....
New insight into infertility: exogenous cortisol (Hydrocortisone) upregulates tight junction genes (CLDN3, CLDN4, ZO-1, DSG1, CDH1) in endometrial cells — potentially hindering blastocyst #implantation. #endometrium #hydrocortisone pmc.ncbi.nlm.nih.gov/articles/PMC...
The effect of Hydrocortisone on implantation through upregulation of tight junction genes: A lab trial study
Emotional stress leading to cortisol release is an important infertility factor in females. Increased cortisol levels can significantly affect tight junction proteins and dysregulate the implantation process. This study investigated the effect of ...
pmc.ncbi.nlm.nih.gov
October 25, 2025 at 7:24 AM
New insight into infertility: exogenous cortisol (Hydrocortisone) upregulates tight junction genes (CLDN3, CLDN4, ZO-1, DSG1, CDH1) in endometrial cells — potentially hindering blastocyst #implantation. #endometrium #hydrocortisone pmc.ncbi.nlm.nih.gov/articles/PMC...
Longer #OperationTime increases postoperative #complications after percutaneous nephrolithotomy. A 65‑min cut-off showed high specificity (96.8%) for predicting risk. Optimizing surgical duration may improve outcomes. journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
October 21, 2025 at 7:16 AM
Longer #OperationTime increases postoperative #complications after percutaneous nephrolithotomy. A 65‑min cut-off showed high specificity (96.8%) for predicting risk. Optimizing surgical duration may improve outcomes. journals.sagepub.com/doi/10.1177/...
Is 15 minutes enough? Our retrospective study of 724 patients shows that the 15‑min head-up tilt test yields results similar to the 20‑min protocol and could improve efficiency and patient comfort. #Syncope #Tilt #Cardiology onlinelibrary.wiley.com/doi/10.1002/...
A Tick of the Clock: Finding the Sweet Spot in Tilt Table Test. The Effectiveness of Short‐Duration Head‐Up Tilt Test as a Diagnostic Tool in Suspected Vasovagal Patients: A Retrospective Observationa...
In patients with suspected vasovagal syncope, a 15-min head-up tilt test protocol yielded similar diagnostic results to the conventional 20-min protocol. This shorter approach may improve patient com....
onlinelibrary.wiley.com
October 20, 2025 at 6:44 AM
Is 15 minutes enough? Our retrospective study of 724 patients shows that the 15‑min head-up tilt test yields results similar to the 20‑min protocol and could improve efficiency and patient comfort. #Syncope #Tilt #Cardiology onlinelibrary.wiley.com/doi/10.1002/...
Rare case of metastatic soft tissue #sarcoma invading the left atrium and pulmonary veins—an exceptional cardiac spread reviewed in detail. #CardioOncology #CaseReport #Oncology onlinelibrary.wiley.com/doi/10.1002/...
An Unusual Presentation of Metastatic Soft Tissue Sarcoma to the Left Atrium and Pulmonary Veins: A Case Report and Comprehensive Literature Review
A summary of the patient's history and treatment process.
onlinelibrary.wiley.com
October 19, 2025 at 5:33 AM
Rare case of metastatic soft tissue #sarcoma invading the left atrium and pulmonary veins—an exceptional cardiac spread reviewed in detail. #CardioOncology #CaseReport #Oncology onlinelibrary.wiley.com/doi/10.1002/...
#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....
Efficacy and safety of colchicine in patients with acute coronary syndrome: a systematic review and meta-analysis of randomized controlled trials - BMC Cardiovascular Disorders
Background The European Society of Cardiology (ESC) recently endorsed low-dose colchicine for chronic coronary syndrome. However, its role in acute coronary syndrome (ACS) remains uncertain due to inc...
bmccardiovascdisord.biomedcentral.com
October 18, 2025 at 6:23 AM
#MetaAnalysis (11 RCTs, n=12,730): #Colchicine shows no cardiovascular benefit in acute coronary syndrome (ACS), though safety remains acceptable. @fadyiskander.bsky.social bmccardiovascdisord.biomedcentral.com/articles/10....
Reposted by Cardiovascular Diseases Research Institute
New study in 'Journal of Diabetes & Metabolic Disorders' reveals high prevalence of metabolic syndrome in Tehran adults. Key risk factors: age, gender, education, and physical activity. 🛟 bit.ly/4gyo5Kf
September 22, 2025 at 2:30 AM
New study in 'Journal of Diabetes & Metabolic Disorders' reveals high prevalence of metabolic syndrome in Tehran adults. Key risk factors: age, gender, education, and physical activity. 🛟 bit.ly/4gyo5Kf
Using the patient’s own right atrial appendage for #tricuspid valve replacement showed perfect 1‑year results—no mortality or regurgitation in 6 cases. A promising step for complex valve repair! #HeartSurgery academic.oup.com/icvts/articl...
Tricuspid Valve Replacement Using the Right Atrial Appendage Valve: Techniques and 1-Year Results
Tricuspid regurgitation (TR) is a significant valve disorder with limited data on management outcomes.
academic.oup.com
October 15, 2025 at 5:29 AM
Using the patient’s own right atrial appendage for #tricuspid valve replacement showed perfect 1‑year results—no mortality or regurgitation in 6 cases. A promising step for complex valve repair! #HeartSurgery academic.oup.com/icvts/articl...
Lower estimated glucose disposal rate (eGDR), a marker of #InsulinResistance, strongly predicts major adverse cardio-cerebrovascular events in both diabetic and non-diabetic populations. #MetaAnalysis journals.sagepub.com/doi/10.1177/...
Sage Journals: Discover world-class research
Subscription and open access journals from Sage, the world's leading independent academic publisher.
journals.sagepub.com
October 14, 2025 at 10:44 AM
Lower estimated glucose disposal rate (eGDR), a marker of #InsulinResistance, strongly predicts major adverse cardio-cerebrovascular events in both diabetic and non-diabetic populations. #MetaAnalysis journals.sagepub.com/doi/10.1177/...
A rare case links Scimitar syndrome with #VaginalAgenesis and a history of imperforate anus — findings that hint at a #VACTERL spectrum association. Highlights the complex interplay of congenital anomalies across organ systems. crcp.tums.ac.ir/index.php/cr...
October 12, 2025 at 5:52 AM
A rare case links Scimitar syndrome with #VaginalAgenesis and a history of imperforate anus — findings that hint at a #VACTERL spectrum association. Highlights the complex interplay of congenital anomalies across organ systems. crcp.tums.ac.ir/index.php/cr...
#Dehydrocorydaline, an #alkaloid from Rhizoma Corydalis, shows strong preclinical potential as a natural #pain reliever with anti-inflammatory and neuroprotective effects. #Analgesia journals.sagepub.com/doi/10.1177/...
EXPRESS: Dehydrocorydaline can be a suitable candidate for analgesic purposes: a review on the current preclinical evidence - Mehdi Dehghani, Behrang Nooralishahi, Fatemeh Rezaee Tazangi, 2025
Pain stands as one of the main factors related to human disability and suffering, with different classifications (e.g., acute/chronic, somatic/visceral, and mal...
journals.sagepub.com
October 11, 2025 at 5:29 AM
#Dehydrocorydaline, an #alkaloid from Rhizoma Corydalis, shows strong preclinical potential as a natural #pain reliever with anti-inflammatory and neuroprotective effects. #Analgesia journals.sagepub.com/doi/10.1177/...