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St. Jude Research @stjuderesearch.bsky.social · 11h

“These structures provide a new model for how Hsp40 and Hsp70 function together and how their malfunction can lead to disease,” said Babis Kalodimos, PhD. The findings offer a foundation for therapeutic strategies targeting chaperone dysfunction.

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St. Jude Research @stjuderesearch.bsky.social · 11h

Researchers used advanced imaging to map the complex in multiple states. The glycine/phenylalanine-rich region of Hsp40 was shown to facilitate client protein handoff to Hsp70 and regulate release, clarifying its role in disease.

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St. Jude Research @stjuderesearch.bsky.social · 11h

Scientists have solved the first complete structures of bacterial heat shock chaperone proteins Hsp40 and Hsp70, revealing how these proteins bind and release misfolded client proteins, a process central to cellular defense against protein aggregation. ow.ly/zaM750XboJ0

First complete structures of heat shock chaperone protein complex reveal handoff mechanism

Explore how structures of full-length heat shock protein complexes including Hsp40, Hsp70, and client proteins reveal how they work together to protect cells.

ow.ly

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St. Jude Research @stjuderesearch.bsky.social · 1d

“The KIDS25 BioHackathon demonstrates how we’re building the St. Jude data science workforce for the future. These aren’t just 72 hours of coding; they’re an investment in the people who will drive the mission forward for years to come,” said @renato_umeton, VP of Data Science.

St. Jude Research @stjuderesearch.bsky.social · 1d

This year, 160 participants worked on 21 projects as many groups embraced the use of artificial intelligence (AI) to tackle their challenges. The best overall project was awarded to the team who developed a multi-modal agentic AI system for prioritizing the effects of cancer variants.

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St. Jude Research @stjuderesearch.bsky.social · 1d

St. Jude recently hosted the KIDS25 BioHackathon, an event connecting students and professionals in bioinformatics, imaging, data science, artificial intelligence and software engineering to develop solutions addressing real-world research challenges.

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St. Jude Research @stjuderesearch.bsky.social · 6d

This discovery clarifies how disruptions in stress granule regulation can contribute to conditions such as multisystem proteinopathy, amyotrophic lateral sclerosis and frontotemporal dementia, highlighting potential therapeutic targets.

St. Jude Research @stjuderesearch.bsky.social · 6d

New findings reveal that the ASPL protein plays distinct roles in both the assembly and disassembly of stress granules—mechanisms linked to neurodegenerative diseases. ow.ly/lCP550X8H3J

Protein sidekick exhibits dual roles in stress granule assembly and disassembly

See how St. Jude researchers reveal how ASPL and VCP control stress granule assembly and disassembly, shedding light on neurodegenerative disease mechanisms.

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St. Jude Research @stjuderesearch.bsky.social · 6d

This discovery clarifies how disruptions in stress granule regulation can contribute to conditions such as multisystem proteinopathy, amyotrophic lateral sclerosis and frontotemporal dementia, highlighting potential therapeutic targets

St. Jude Research @stjuderesearch.bsky.social · 7d

St. Jude is advancing therapies such as immunotherapy and precision medicine while expanding global access to care through collaborations with WHO, UNICEF and others.

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St. Jude Research @stjuderesearch.bsky.social · 7d

"To be named among the top children’s cancer hospitals every year since the rankings began is a reflection of our people—their brilliance, their heart and their unwavering commitment to our mission,” said James R. Downing, MD, president and CEO.

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St. Jude Research @stjuderesearch.bsky.social · 7d

St. Jude Children’s Research Hospital has been ranked among the top 10
pediatric cancer hospitals by U.S. News & World Report for the 18th year in a row.

Read more: ow.ly/HNLN50X7PsR

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St. Jude Research @stjuderesearch.bsky.social · 11d

Alongside wellness programs, growth opportunities and more, our new childcare center sets us apart in our support of our staff’s well-being. “The center was near full subscription not long after opening,” said Maria Megdal, EVP and chief administrative officer.

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St. Jude Research @stjuderesearch.bsky.social · 11d

Proud to be ranked No. 2 on the @Forbes list of Best Employers for Healthcare Professionals! At St. Jude, we invest in our team so they can focus on our lifesaving mission.

ow.ly/HPal50X6mBj

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St. Jude Research @stjuderesearch.bsky.social · 11d

The application deadline for the 2026 CCSS Ann C. Mertens Career Development Award has been extended through Monday, November 3.

This is a great opportunity for early-career investigators and trainees interested in childhood cancer survivorship research. Learn more: ow.ly/GOzN50WCMpP

St. Jude Research @stjuderesearch.bsky.social · Aug 11

Shape the future of childhood cancer survivorship with the 2026 CCSS Ann C. Mertens Career Development Award. This opportunity provides early-career investigators with the tools, resources and mentorship to advance survivorship research and improve outcomes.

Mostly blue graphic with text containing the announcement of the 2026 Career Development Award from the Childhood Cancer Survivor Study with an October 6, 2025 deadline.

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St. Jude Research @stjuderesearch.bsky.social · 13d

“These methods are now being used by other labs to study important processes in the brain in ways that haven’t been done before,” said @lindsayschwarz.bsky.social, PhD. As technology continues to evolve, St. Jude researchers are lighting the way to new knowledge.

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St. Jude Research @stjuderesearch.bsky.social · 13d

Innovations include self-healing fluorophores for more precise imaging, an intersectional genetic platform to label rare neuronal populations and the first visualization of cytonemes in mammalian tissue. All discoveries are driven by advances in fluorescence and microscopy.

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St. Jude Research @stjuderesearch.bsky.social · 13d

St. Jude researchers are advancing science by harnessing light-based technologies to explore the molecular and cellular mechanisms underlying health and disease. ow.ly/3TEI50X4nsQ

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St. Jude Research @stjuderesearch.bsky.social · 14d

The work continues. Register to join us at our October stakeholder engagement webinar to keep building hope and better outcomes for kids everywhere. ow.ly/3KSv50X4nfh

#GlobalHealth #UNGA

The Global Platform in Action: How Country-Led Collaboration is Strengthening Access to Childhood Cancer Medicines

In this upcoming Stakeholder Engagement Dialogue, we offer a unique look into the preparations made by participating countries to achieve readiness through multisectoral collaboration and collective a...

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St. Jude Research @stjuderesearch.bsky.social · 14d

This event showed the power of collaboration, sharing best practices, fostering new partnerships, & driving action for sickle cell disease and childhood cancer. The convening power of St. Jude brings leaders together to build lasting, resilient health systems for all children.

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St. Jude Research @stjuderesearch.bsky.social · 14d

At #UNGA80, St. Jude & Uzbekistan co-hosted a landmark side event, united by Bente Mikkelsen’s leadership, 8 first ladies, WHO DG @DrTedros & ministers of health worldwide. Together, we’re advancing global health for children facing catastrophic diseases.

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St. Jude Research @stjuderesearch.bsky.social · 15d

If successful, this technology could improve the accuracy of infection diagnosis, reduce unnecessary procedures and advance care for patients with sickle cell disease. Future trials will focus on its application in clinical settings.

St. Jude Research @stjuderesearch.bsky.social · 15d

“[18F]fluoromannitol’s ability to accumulate only in bacteria indicated it to be a sensitive bacterial imaging agent worthy of further investigation,” said Kiel Neumann, PhD.

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St. Jude Research @stjuderesearch.bsky.social · 15d

A novel radiotracer, [18F]fluoromannitol, is now entering a first-in-human clinical trial at St. Jude. This PET/CT imaging agent could help clinicians distinguish between disease-related inflammation and bacterial infection in patients with sickle cell disease. ow.ly/PV9u50X3PJn

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St. Jude Research @stjuderesearch.bsky.social · 15d

“Achieving exceptional status for the third consecutive time is a testament to the work of our faculty and staff members, and the impact this Center has on pediatric cancer research and treatment,” said Charles Roberts, MD, PhD.