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Chris Wells @stemcellsystems.bsky.social · 1d

Transitions is the newest in our series of stem cell conversations. Launched by Ritika Saxena, Jarmon Lees and @osvaldoics.bsky.social we explore project and career transitions. All the parts needed for successful science that don't make it to the bench. For Aussie scientists, but all welcome.

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Chris Wells @stemcellsystems.bsky.social · 1d

We are celebrating 5 years of the Australia stem cell conversation! Hosted by @unimelb.bsky.social and @asscr.bsky.social the stem cell conversation is a weekly 30min virtual seminar series organised by EMCR for EMCR.
Join the first 'transitions' episode Leadership through Service: 11am AEST Wed.

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Chris Wells @stemcellsystems.bsky.social · 20d

New from the lab - How FAIR is metadata for human pluripotent stem cells? Registered cell lines are more likely to be cited, shared and reused across different studies - but most lines are difficult to find or lack key information. Stem Cell Reports www.cell.com/stem-cell-re...

How FAIR is metadata for human pluripotent stem cells?

In this article, Wells and colleagues present the first systematic FAIR evaluation of stem cell data infrastructures. Case studies from, but not limited to, the United States, Japan, Europe, and Austr...

www.cell.com

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Chris Wells @stemcellsystems.bsky.social · Jun 10

Day 2 #HCA2025GM day two demonstrates the power of global representation in genome and cell maps. @patriciasevero.bsky.social

A woman speaks to an audience about the importance of leveraging local experts in global science missions

Reposted by Chris Wells

Human Cell Atlas @humancellatlas.org · Jun 10

Virtual attendees can use their registration email to watch the livestream at: buff.ly/Jlsw8X6

Session Details

Keynote Day 2 Session Chair: Shyam Prabhakar Speaker:

events.humancellatlas.org

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Chris Wells @stemcellsystems.bsky.social · Jun 9

Consortium priorities - integrate the atlases into a whole body view; create 2D/3/D spatially resolved atlases and 3/ build global representation including for disease networks to benefit global health.

A slide describing global representation of the HCA for health benefit for all.

Chris Wells @stemcellsystems.bsky.social · Jun 9

It will be interesting to see how researchers use generative AI to explore these data. It will certainly open up equitable access to the data.

Chris Wells @stemcellsystems.bsky.social · Jun 9

Human Cell Atlas data now hosted on @amazonaws.bsky.social OpenData servers - aws.amazon.com/marketplace/...

AWS Marketplace: Human Cell Atlas

aws.amazon.com

Chris Wells @stemcellsystems.bsky.social · Jun 9

The human cell atlas #HCA2025GM really showcases descriptive science at scale - an atlas of human cells that engages globally. It's an exciting grass roots project. Equity and capability building are a core principle - as are coordinated networks focused on tissue specific atlases.

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Chris Wells @stemcellsystems.bsky.social · Jun 9

The room is buzzing in Singapore #HCA2025GM

Human Cell Atlas @humancellatlas.org · Jun 9

We’re excited to start the 2025 HCA General Meeting today. Looking forward to many insightful discussions and collaborations. You can still register to attend virtually at buff.ly/eZiIwaB #HCA2025GM

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Chris Wells @stemcellsystems.bsky.social · Jun 9

Very happy to be in Singapore for #HCA2025GM

Human Cell Atlas @humancellatlas.org · Jun 9

We’re excited to start the 2025 HCA General Meeting today. Looking forward to many insightful discussions and collaborations. You can still register to attend virtually at buff.ly/eZiIwaB #HCA2025GM

Chris Wells @stemcellsystems.bsky.social · Dec 9

Congratulations Irene!

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Chris Wells @stemcellsystems.bsky.social · Dec 9

Thanks!

Reposted by Chris Wells

Kat Mayer-Barber,PhD @mayerbarber.bsky.social · Dec 6

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9

Graphical summary of our paper. In mice, prior lower airway exposure to diverse inflammatory stimuli, including chronic bacterial infections such as M. tuberculosis, acute bacterial infections such as pulmonary S. aureus, viral infections such as Influenza A, type-II allergic responses such as the OVA-Alum model, activation of pulmonary TLR9 by CpG or pulmonary TLR1/2 by Pam3CSK4
leads to reduced viral burden upon subsequent infection with SARS-CoV-2 (SCV2). (2) This SCV2 restriction occurs prior to induction of SCV2-specific adaptive immune responses
and is mediated through innate immune responses, including the induction of IFN-I, TNFα and IL-1 and sustained changes to the TRM (Tissue resident macrophage) cellular
compartment and the pulmonary epithelium. (3) Innate cytokine and TLR signaling to both recruited immune cells and the pulmonary epithelium creates a microenvironment in the
lung that limits early replication of SCV2. IFN-I signaling to pulmonary ECs (epithelial cells) increases expression of interferon-stimulated genes, that likely cell-intrinsically limit viral
replication. TNF- or IL-1 suppress SCV2 independently of IFN-I signaling. TNF acts exclusively through radio-resistant cell types such as the lung epithelium, whereas IL-1 affords
control both direct and indirectly, through either stromal and hematopoietic cell types, to restrict overall early SCV2 burden.

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Reposted by Chris Wells

Human Cell Atlas @humancellatlas.org · Dec 7

We’re so pleased to see #HumanCellAtlas 🖥️🧬 on the cover of Nature
illustrating the breadth of the HCA initiative, overlaying a subway-style network of biological systems on a detailed cellular map. Congratulations to Claire Agosti from SayoStudio and Anna Hupalowska

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Chris Wells @stemcellsystems.bsky.social · Dec 6

What a beautiful mechanistic 🧪 insight into the collaboration between macrophages and dendritic cells, even in death. Congratulations @inflammasomelab.bsky.social and team! doi.org/10.1038/s415...

Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells - Nature Immunology

Pyroptotic cell death results in inflammation. Here the authors find that F-actin-rich structures formed during macrophage pyroptosis persist after cell death to activate dendritic cells.

doi.org

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Thanks Andy

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Thank you, You’ve taught me something new!

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Well that’s a wrap #ICSB2024 🧪- terrific conference! ICSB2025 in Dublin 5-9 October #Ireland

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Paywalled - anyone willing to share?

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Presented today at #ICSB2024 by @chaitraagrahar.bsky.social - very clear presentation of a complex concept #SystemsBiology #MathematicalBiology

Chaitra Agrahar @chaitraagrahar.bsky.social · Dec 5

Thank you Christine! Yes, we have the work I presented today as a preprint: arxiv.org/abs/2402.04498

Pathspace Kalman Filters with Dynamic Process Uncertainty for Analyzing Time-course Data

Kalman Filter (KF) is an optimal linear state prediction algorithm, with applications in fields as diverse as engineering, economics, robotics, and space exploration. Here, we develop an extension of ...

arxiv.org

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Final plenary of #ICSB2024 from Tim Schroeder @ethzurich.bsky.social making the case for long term live cell measurements doi.org/10.1084/jem....

Analyzing signaling activity and function in hematopoietic cells | Journal of Experimental Medicine | Rockefeller University Press

doi.org

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Reposted by Chris Wells

Indian Society of Developmental Biologists @insdb.bsky.social · Dec 5

InSDB is running a virtual postdoc talk series for postdocs to present their work and share their science! We meet once every month for two fascinating talks.
If you are a postdoc, do sign up to be a speaker now-our slots are filling up
t.co/9j0NsvGSZw
Do share & spread the word among #DevBio folks!

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Nice job @chaitraagrahar.bsky.social - interesting #ISCB2024 talk. Will you publish your method? Would love to read further.

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Chris Wells @stemcellsystems.bsky.social · Dec 5

Gorgeous work, conceptually and in application- congratulations