Sophie Goldsmith
@sophie0g.bsky.social
🫐🫧PhD student working with forebrain organoids & microglia to study FTD | Wray Lab, UCL 🧫🧠 & coordinate the GENFI participant engagement board
https://www.justgiving.com/page/sophie-goldsmith-3
https://www.justgiving.com/page/sophie-goldsmith-3
Always an exciting day when you get images like these ✨⭐️
November 19, 2025 at 5:44 PM
Always an exciting day when you get images like these ✨⭐️
I have thoroughly enjoyed writing for @pet-bionews.bsky.social the last 6 weeks as part of their BioNews writing scheme!
This week I had the pleasure of reviewing a seminar on the ethics of organoid and chimaera research 🧠🧫.
See the link below to read!
www.progress.org.uk/event-review...
This week I had the pleasure of reviewing a seminar on the ethics of organoid and chimaera research 🧠🧫.
See the link below to read!
www.progress.org.uk/event-review...
Event Review: HDBI Ethics Seminar – Ethics of human brain organoids and human-animal chimaeras | PET
Professor John Evans discusses investigations into the US public's opinion on the use of human brain organoids and human-animal chimaeras in research.
www.progress.org.uk
November 17, 2025 at 5:46 PM
I have thoroughly enjoyed writing for @pet-bionews.bsky.social the last 6 weeks as part of their BioNews writing scheme!
This week I had the pleasure of reviewing a seminar on the ethics of organoid and chimaera research 🧠🧫.
See the link below to read!
www.progress.org.uk/event-review...
This week I had the pleasure of reviewing a seminar on the ethics of organoid and chimaera research 🧠🧫.
See the link below to read!
www.progress.org.uk/event-review...
Reposted by Sophie Goldsmith
Look at these beautiful organoids grown by @sophie0g.bsky.social ! Who needs fireworks when we can look down the microscope at these stunners 😎
🔬 These images show forebrain organoids that are grown at the UCL Wray Lab to study dementia. This research focuses on a genetic form of frontotemporal dementia, and the colours confirm that the organoids have developing neurons (neural progenitors).
📸: Sophie Goldsmith, @uclqsion.bsky.social
📸: Sophie Goldsmith, @uclqsion.bsky.social
November 5, 2025 at 5:08 PM
Look at these beautiful organoids grown by @sophie0g.bsky.social ! Who needs fireworks when we can look down the microscope at these stunners 😎
Reposted by Sophie Goldsmith
A woman seeking to understand why she has two genetic conditions, despite no family history, discovered that her mother’s #fertility doctor was her biological father. Sophie Goldsmith writes in BioNews: www.progress.org.uk/fertility-fr...
#FertilityTreatment #FertilityClinics #Infertility
#FertilityTreatment #FertilityClinics #Infertility
November 4, 2025 at 6:25 PM
A woman seeking to understand why she has two genetic conditions, despite no family history, discovered that her mother’s #fertility doctor was her biological father. Sophie Goldsmith writes in BioNews: www.progress.org.uk/fertility-fr...
#FertilityTreatment #FertilityClinics #Infertility
#FertilityTreatment #FertilityClinics #Infertility
Reposted by Sophie Goldsmith
A rare eye #Cancer which may have otherwise been missed, has been detected in a newborn baby enrolled in @genomicsengland.bsky.social WGS study: The Generation Study. Sophie Goldsmith writes in BioNews:
www.progress.org.uk/rare-eye-can...
#Cancer #EyeCancer #Gene #genomics #genetics #Genome #DNA
www.progress.org.uk/rare-eye-can...
#Cancer #EyeCancer #Gene #genomics #genetics #Genome #DNA
October 27, 2025 at 6:18 PM
A rare eye #Cancer which may have otherwise been missed, has been detected in a newborn baby enrolled in @genomicsengland.bsky.social WGS study: The Generation Study. Sophie Goldsmith writes in BioNews:
www.progress.org.uk/rare-eye-can...
#Cancer #EyeCancer #Gene #genomics #genetics #Genome #DNA
www.progress.org.uk/rare-eye-can...
#Cancer #EyeCancer #Gene #genomics #genetics #Genome #DNA
Super excited to be running the London Landmarks Half next April for The National Brain Appeal 🧠🏃🏼♀️ just set up my just giving page - any donations / sharing my page would be FAB ⭐️
www.justgiving.com/page/sophie-...
www.justgiving.com/page/sophie-...
August 14, 2025 at 3:26 PM
Super excited to be running the London Landmarks Half next April for The National Brain Appeal 🧠🏃🏼♀️ just set up my just giving page - any donations / sharing my page would be FAB ⭐️
www.justgiving.com/page/sophie-...
www.justgiving.com/page/sophie-...
Reposted by Sophie Goldsmith
What a treat to share a walkies and a BBQ with my colleagues.
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
July 21, 2025 at 7:24 PM
What a treat to share a walkies and a BBQ with my colleagues.
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
The rain in the background caught us on the way home. But that’s normal for a British bbq, right?
Reposted by Sophie Goldsmith
Feat. @sophie0g.bsky.social presenting her organoid work! 🧠
Next UCL ALS-FTD Network Seminars - 25 July at 4pm, Gilliatt LT, QSH.
'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs'
'Generation of a universal human cellular platform for drug testing in ALS'
'A forebrain organoid model of progranulin-associated FTD'
'Investigating pathomechanisms in Charcot-Marie-Tooth disease using mouse models and iPSCs'
'Generation of a universal human cellular platform for drug testing in ALS'
'A forebrain organoid model of progranulin-associated FTD'
July 9, 2025 at 8:38 PM
Feat. @sophie0g.bsky.social presenting her organoid work! 🧠
Thrilled to share that I passed my PhD upgrade viva yesterday!Extremely grateful for all the support I’ve had from my supervisors & team who have helped me get to this point & a big thank you to my upgrade panel for the insightful feedback & discussion. 🧫🧠 @selinawray.bsky.social
June 26, 2025 at 11:00 AM
Thrilled to share that I passed my PhD upgrade viva yesterday!Extremely grateful for all the support I’ve had from my supervisors & team who have helped me get to this point & a big thank you to my upgrade panel for the insightful feedback & discussion. 🧫🧠 @selinawray.bsky.social
Reposted by Sophie Goldsmith
New paper from the lab, under the leadership of @celarber.bsky.social !
'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social
molecularneurodegeneration.biomedcentral.com/articles/10....
Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration
Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...
molecularneurodegeneration.biomedcentral.com
June 21, 2025 at 9:22 AM
New paper from the lab, under the leadership of @celarber.bsky.social !
Super exciting that The Brain at Rest is out! Was a huge privilege to be Joe’s research assistant for this book, searching through all the research papers & learning so much in the process! Huge thank you to Joe for this opportunity to help out on such a fab project! Go give it a read ☺️
June 19, 2025 at 4:25 PM
Super exciting that The Brain at Rest is out! Was a huge privilege to be Joe’s research assistant for this book, searching through all the research papers & learning so much in the process! Huge thank you to Joe for this opportunity to help out on such a fab project! Go give it a read ☺️
Had a fantastic time at the FTDUK conference yesterday in Edinburgh ⭐️🧠so many brilliant talks - exciting to hear about the cutting edge FTD research & clinical trials underway!
May 31, 2025 at 9:21 AM
Had a fantastic time at the FTDUK conference yesterday in Edinburgh ⭐️🧠so many brilliant talks - exciting to hear about the cutting edge FTD research & clinical trials underway!
Was a huge pleasure to co-host the 2nd GENFI Participant Webinar on Friday! Nearly 100 attendees and a fantastic lineup of speakers—thank you to everyone who joined and to all the speakers for their brilliant talks! Followed by a hugely informative participant engagement board roundtable!
April 14, 2025 at 12:38 PM
Was a huge pleasure to co-host the 2nd GENFI Participant Webinar on Friday! Nearly 100 attendees and a fantastic lineup of speakers—thank you to everyone who joined and to all the speakers for their brilliant talks! Followed by a hugely informative participant engagement board roundtable!
Fab first day at the Stem Cell Models of Neurodegeneration conference in Edinburgh! 🧠 #SCMND So many exciting talks, and I really enjoyed presenting my poster with the work from the first year of my PhD! Looking forward to the rest of the conference! 🧫🧠
March 26, 2025 at 9:42 PM
Fab first day at the Stem Cell Models of Neurodegeneration conference in Edinburgh! 🧠 #SCMND So many exciting talks, and I really enjoyed presenting my poster with the work from the first year of my PhD! Looking forward to the rest of the conference! 🧫🧠
Reposted by Sophie Goldsmith
This was so powerful - few of us can imagine the reality of having a family devastated by familial FTD - and the response of Jordan/Cian to their own risk is incredibly inspiring. Find them in instagram/TikTok as the FTD Brothers and follow their story…!
@alzheimersresearchuk.org supporter Jordan Adams opens our research conference.
Jordan speaks so passionately about his mum’s diagnosis and journey with Frontotemporal Dementia, his own risk of developing it and why he’s relentlessly raising money for dementia research.
Unbelievably inspiring 🧡
Jordan speaks so passionately about his mum’s diagnosis and journey with Frontotemporal Dementia, his own risk of developing it and why he’s relentlessly raising money for dementia research.
Unbelievably inspiring 🧡
February 25, 2025 at 10:02 AM
This was so powerful - few of us can imagine the reality of having a family devastated by familial FTD - and the response of Jordan/Cian to their own risk is incredibly inspiring. Find them in instagram/TikTok as the FTD Brothers and follow their story…!
Reposted by Sophie Goldsmith
Hello BlueSky. One of our cofounders, Linde Jacobs, is profiled in The New York Times today. It’s a moving snapshot of what an FTD family goes through. Help us fight for therapies that can cure dementia for under 60s. #ftd #aftd #dementia #tau #alzheimers #mapt
www.nytimes.com/2024/12/22/h...
A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate (Gift Article)
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
www.nytimes.com
December 22, 2024 at 2:57 PM
Hello BlueSky. One of our cofounders, Linde Jacobs, is profiled in The New York Times today. It’s a moving snapshot of what an FTD family goes through. Help us fight for therapies that can cure dementia for under 60s. #ftd #aftd #dementia #tau #alzheimers #mapt
www.nytimes.com/2024/12/22/h...
Getting some final images before going on Xmas break! 🧫🎄GFAP & Nestin staining in forebrain organoids using whole mount ICC 🧠
December 19, 2024 at 5:33 PM
Getting some final images before going on Xmas break! 🧫🎄GFAP & Nestin staining in forebrain organoids using whole mount ICC 🧠
Reposted by Sophie Goldsmith
Lab holiday photo 2024 ☺️☺️
Feat. @celarber.bsky.social @sophie0g.bsky.social @lecrawf0.bsky.social and many more not in the bluesky yet :)
Feat. @celarber.bsky.social @sophie0g.bsky.social @lecrawf0.bsky.social and many more not in the bluesky yet :)
December 12, 2024 at 6:17 PM
Lab holiday photo 2024 ☺️☺️
Feat. @celarber.bsky.social @sophie0g.bsky.social @lecrawf0.bsky.social and many more not in the bluesky yet :)
Feat. @celarber.bsky.social @sophie0g.bsky.social @lecrawf0.bsky.social and many more not in the bluesky yet :)
Fantastic talk yesterday from @bowleslab.bsky.social discussing tau & iPSC models 🧠🧫 & was lovely to meet you after! ☺️
November 27, 2024 at 9:52 AM
Fantastic talk yesterday from @bowleslab.bsky.social discussing tau & iPSC models 🧠🧫 & was lovely to meet you after! ☺️
Reposted by Sophie Goldsmith
Excited to share the lab's recent publication. Granulins are critical for lysosome function and brain health to prevent neurodegeneration. Our data suggest that granulin peptides could be used to treat frontotemporal dementia (FTD), Parkinson’s disease, Alzheimer’s disease.
t.co/pN28kabjIA
t.co/pN28kabjIA
November 21, 2024 at 8:48 PM
Excited to share the lab's recent publication. Granulins are critical for lysosome function and brain health to prevent neurodegeneration. Our data suggest that granulin peptides could be used to treat frontotemporal dementia (FTD), Parkinson’s disease, Alzheimer’s disease.
t.co/pN28kabjIA
t.co/pN28kabjIA
Reposted by Sophie Goldsmith
🧠 130 people now in this UK Dementia Starter Pack! 🧠
📈 (50 more than 2 days ago!) 📈
A great mix of Profs/PIs/Post-docs/PhDs/Technicians.
Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋
go.bsky.app/S6FfsTp
📈 (50 more than 2 days ago!) 📈
A great mix of Profs/PIs/Post-docs/PhDs/Technicians.
Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋
go.bsky.app/S6FfsTp
November 21, 2024 at 2:08 PM
🧠 130 people now in this UK Dementia Starter Pack! 🧠
📈 (50 more than 2 days ago!) 📈
A great mix of Profs/PIs/Post-docs/PhDs/Technicians.
Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋
go.bsky.app/S6FfsTp
📈 (50 more than 2 days ago!) 📈
A great mix of Profs/PIs/Post-docs/PhDs/Technicians.
Please re-post so it can reach a wider audience as I'm sure there are more of us out there ☺️🦋
go.bsky.app/S6FfsTp
Reposted by Sophie Goldsmith
Very happy to share our paper on Familial British Dementia (FBD) which is online today!
Using patient iPSC,we show the amyloidogenic peptide in this disease -ABri -is mainly produced by microglia…
Never heard of FBD? You won’t be the only one… explainer incoming!
link.springer.com/article/10.1...
Using patient iPSC,we show the amyloidogenic peptide in this disease -ABri -is mainly produced by microglia…
Never heard of FBD? You won’t be the only one… explainer incoming!
link.springer.com/article/10.1...
Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica
Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...
link.springer.com
November 15, 2024 at 12:53 PM
Very happy to share our paper on Familial British Dementia (FBD) which is online today!
Using patient iPSC,we show the amyloidogenic peptide in this disease -ABri -is mainly produced by microglia…
Never heard of FBD? You won’t be the only one… explainer incoming!
link.springer.com/article/10.1...
Using patient iPSC,we show the amyloidogenic peptide in this disease -ABri -is mainly produced by microglia…
Never heard of FBD? You won’t be the only one… explainer incoming!
link.springer.com/article/10.1...