Sean McGeary
@seanemcgeary.bsky.social
Postdoc in the KleinLabHMS at HMS_SysBio. Bartel Lab alum. Interested in cellular decision making and gene regulation. Pro bono music critic. Aspirational film buff.
Reposted by Sean McGeary
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
March 15, 2025 at 12:36 AM
Check out the latest study from our lab, led by @mhall98.bsky.social :
www.biorxiv.org/content/10.1... (1/2)
www.biorxiv.org/content/10.1... (1/2)
Reposted by Sean McGeary
Divide and conquer. Or don’t divide but still conquer.
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
Divide and conquer. Or don't divide but still conquer. - the Node
Behind the paper story for "Cell state transitions are decoupled from cell division during early embryo development" As embryos develop, their cells
thenode.biologists.com
January 27, 2025 at 12:04 PM
Divide and conquer. Or don’t divide but still conquer.
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
@kkukreja.bsky.social & co. looked into the role of cell division in forming all major cell types during early zebrafish 🐟development, and found something they didn't expect. Read the story behind the paper:
Happy to have my first Bluesky post say I’m genuinely sad at the loss of David Lynch.
January 17, 2025 at 4:15 AM
Happy to have my first Bluesky post say I’m genuinely sad at the loss of David Lynch.
Reposted by Sean McGeary
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @voslab.org and @bartellab.bsky.social with @amohamed98.bsky.social
Our collaborative AGO2 work with @bartellab.bsky.social is published! Abdallah and Peter used cryo-EM and biochemistry to determine the structure of AGO2 in a slicing competent conformation with a fully paired RNA. Read more about it here: tinyurl.com/AGO2-slicing
The structural basis for RNA slicing by human Argonaute2
Mohamed et al. report the cryoelectron microscopy structure of human AGO2 with fully paired guide RNA. Their analysis reveals the structural basis for the slicing activity that drives RNAi, showing that the slicing-competent conformation is achieved by domain movements and RNA-protein contacts distinct from those of conformational intermediates and prokaryotic homologs.
tinyurl.com
January 1, 2025 at 6:31 PM
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @voslab.org and @bartellab.bsky.social with @amohamed98.bsky.social
Reposted by Sean McGeary
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
January 2, 2025 at 9:55 PM
Excited to share our review article "Finding functional microproteins", published in @TrendsGenetics. It was fun writing it together with Alex and @FeiyueYang1 in the lab. #microprotein authors.elsevier.com/a/1kNCscQbJB...
Reposted by Sean McGeary
We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!
Lysosomal reduced thiols are essential for mouse embryonic development https://www.biorxiv.org/content/10.1101/2024.12.26.630348v1
December 27, 2024 at 8:55 PM
We’ve preprinted a small follow-up to our identification of MFSD12 as a mediator of lysosomal cysteine import. Would love to discuss, so please get in contact if you have comments or suggestions!