Schuller Jan
@schullerjm.bsky.social
Reposted by Schuller Jan
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
December 8, 2025 at 5:20 PM
Last Friday was the defense of my PhD thesis entitled "Structural basis of anaerobic enzymes mediated by noncanonical metalloclusters" after 4 yrs at the @synmikro.bsky.social 🎓🎓
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
Big thanks to my supervisor @schullerjm.bsky.social and the whole Schuller lab for their continuous and massive support!
The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
November 25, 2025 at 9:15 AM
The largest challenge of the day. Try to assemble 5 structural biology papers (each more than 100 pages incl. Supplements) in a single pdf with less than 15MB to upload as a document for a prize nomination for a student. Not sure compression algorithms are that good...
Reposted by Schuller Jan
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
November 2, 2025 at 7:13 PM
📢 Postdoc position: Cell Biology of Cyanobacteria
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany.
More information at shorturl.at/wNnDT (see Project 2)
🔗Apply at shorturl.at/VsEDl
📅Deadline: Nov 16, 2025
Please repost. #Postdoc
Reposted by Schuller Jan
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Origin of chaperone dependence and assembly complexity in Rubisco biogenesis
Molecular chaperones assist with the folding and assembly of protein clients. Consequently, they are essential to diverse cellular functions. In most aerobic photosynthetic organisms such as B-cyanoba...
www.biorxiv.org
September 24, 2025 at 7:53 PM
A new preprint from the lab. I won't do a tweetorial until this is peer reviewed, but I think it's a banger, led by
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
@JedNzy. It's about Rubisco and what chaperones are really for. He's on the market, get him while you can. www.biorxiv.org/content/10.1...
Reposted by Schuller Jan
Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung!
@synmikro.bsky.social @loewe-tree-m.bsky.social.
@synmikro.bsky.social @loewe-tree-m.bsky.social.
Dr. Jan Schuller erhält renommiertes Boehringer Ingelheim Stiftung (BIS) Stipendium. Im Fokus: Wie schädliche #Darmbakterien ohne #Sauerstoff Energie gewinnen – die Funktionsweise von #Clostridioides difficile uni-marburg.de/eOYjSV Foto: R K Wegst #Mikrobiologie #Kryo-Elektronenmikroskopie
September 5, 2025 at 3:15 PM
Die aller♥️lichsten Glückwünsche🍾🥂auch von uns an Jan Schuller, Wissenschaftler👨🏼🔬bei LOEWE-Tree-M & zuvor bereits beim ehem. LOEWE-Zentrum SYNMIKRO, zu seinem #Explorationsstipendium der Boehringer Ingelheim Stiftung!
@synmikro.bsky.social @loewe-tree-m.bsky.social.
@synmikro.bsky.social @loewe-tree-m.bsky.social.
Reposted by Schuller Jan
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Structures of dynamic interactors at native proteasomes by PhIX-MS and cryoelectron microscopy
Proteasome function depends on a network of transient interactions that remain structurally and functionally unresolved. We developed PhIX-MS (Photo-induced In situ Crosslinking-Mass Spectrometry), a ...
www.biorxiv.org
August 5, 2025 at 4:21 PM
‼️ Exciting new preprint from a close collaboration with Kylie Walters' group. Our study maps the binding sites of key regulators of the proteasome in situ.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Schuller Jan
Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q
He wants to reveal the secret behind the body's battery
YouTube video by Wallenbergstiftelserna
youtu.be
August 1, 2025 at 1:28 PM
Thank you Knut and Alice Wallenberg Foundation for producing this wonderful video on our research, and for the generous long-term support on our work. youtu.be/A12FvTn812Q
Reposted by Schuller Jan
#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
July 29, 2025 at 12:29 PM
#PhDposition #OrganicChemistry #ChemBio - deadline 03.08 - please RT ❤️ Application online stellenangebote.uni-marburg.de/jobposting/d...
Reposted by Schuller Jan
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Non-antibiotics disrupt colonization resistance against enteropathogens
Nature - Non-antibiotic drugs from a wide range of therapeutic classes can alter the ability of gut commensals to resist invasion by enteropathogens, a previously underappreciated side effect of...
rdcu.be
July 16, 2025 at 9:20 PM
Finally online!
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Our latest research is out @nature.com: We show that non-antibiotic drugs can disrupt colonization resistance, raising the risk of enteric infections.
rdcu.be/ewwrG
Reposted by Schuller Jan
we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎)
#MicroSky
#MicroSky
June 20, 2025 at 11:17 PM
we were already happy that these fascinating microbes were called 𝗶𝗻𝘁𝗿𝗮𝘁𝗲𝗿𝗿𝗲𝘀𝘁𝗿𝗶𝗮𝗹𝗲𝘀, but 𝗮𝗲𝗼𝗻𝗼𝗽𝗵𝗶𝗹𝗲𝘀 sounds definitively more, well... scientific (😎)
#MicroSky
#MicroSky
Reposted by Schuller Jan
Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
June 4, 2025 at 7:41 PM
Amazing paper, the best of two worlds- combination of high resolution cryoEM and small proteins - posttranslational Regulation of the core bioenergetic machinery of methanogenesis by a small protein! Well done Tristan and Eva!!👍🥂🥂 @schullerjm.bsky and @Schmitz-Streit lab - possible through @dfg.de
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
June 4, 2025 at 7:10 PM
Proud to present the lab's latest work. The full structure of the sodium translocating methyltransferase (Mtr) bound to a small oxygen-responsive small protein MtrI. Work by Tristan and together with @schmitzstreitslab.bsky.social .
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
www.biorxiv.org/content/10.1101/2025.06.02.657420v1
Reposted by Schuller Jan
Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
June 3, 2025 at 5:19 PM
Our structural core gene pipeline Unicode is now published at GBE
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
📄 doi.org/10.1093/gbe/...
Please also check out @dongwookkim.bsky.social’s
🧵 bsky.app/profile/dong...
Reposted by Schuller Jan
Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Small ORF16 modulates the Mtr complex activity in Methanosarcina mazei Gö1 depending on the molecular hydrogen availability
Small open reading frame (small ORF)-encoded proteins, with less than 100 amino acids in length, have attracted increasing attention over the past decade after being largely overlooked due to limitati...
www.biorxiv.org
June 2, 2025 at 3:58 PM
Check out our latest preprint on small proteins with big impact: MtrR fine-tunes energy metabolism in M.mazei by modulating the Mtr complex in response to H₂. Great work of Tim Habenicht + @SPP2002 collegues + @schullerjm.bsky.social - congrats TIM, 2. step to PhD!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Schuller Jan
![Comic. PERSON: It’s weird how, despite being one of the main branches of the tree of life, no archaea species are known to cause disease in humans. PERSON WITH SHORT HAIR: Personally, I think it’s because those gross methane breathers are too weird and incompetent to figure out how to hurt us even if they wanted to. [from small point under microscope on desk]: *Hey!* [caption] Bad news: After overhearing a conversation in our lab, Archaea has finally started harming humans.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cz73r7iyiqn26upot4jtjdhk/bafkreibeun6ux6wr6w76uv3nubobmc2aydwd2onzh525sxr3soufnc52pe@jpeg)
Reposted by Schuller Jan
Here is one big reason to choose Europe to advance with your research career:
We 💙 science.
We 💙 science.
May 23, 2025 at 3:03 PM
Here is one big reason to choose Europe to advance with your research career:
We 💙 science.
We 💙 science.
Reposted by Schuller Jan
Want to try LocScale-2.0 without installing locally?
Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud.
edu.nl/ur3ge
Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud.
edu.nl/ur3ge
May 22, 2025 at 11:05 AM
Want to try LocScale-2.0 without installing locally?
Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud.
edu.nl/ur3ge
Check out ColabScale: just upload your maps or enter your favourite EMDB ID and run LocScale-2.0 in the cloud.
edu.nl/ur3ge
Reposted by Schuller Jan
🎉Doppelerfolg für die #UniMarburg in der Exzellenzstrategie! 🎉 Zwei Cluster zu Klimawandel und menschlicher Wahrnehmung sichern sich Förderung. Marburg beweist Forschungsstärke und Innovationskraft.🚀 @proloewe.bsky.social @synmikro.bsky.social @maxplanck.de @jlugiessen.bsky.social @tuda.bsky.social
Marburg feiert Doppelerfolg in der Exzellenzstrategie
Zwei Cluster erhalten Förderung im wichtigsten deutschen Forschungswettbewerb
www.uni-marburg.de
May 22, 2025 at 3:16 PM
🎉Doppelerfolg für die #UniMarburg in der Exzellenzstrategie! 🎉 Zwei Cluster zu Klimawandel und menschlicher Wahrnehmung sichern sich Förderung. Marburg beweist Forschungsstärke und Innovationskraft.🚀 @proloewe.bsky.social @synmikro.bsky.social @maxplanck.de @jlugiessen.bsky.social @tuda.bsky.social
Reposted by Schuller Jan
📢 Wir sind stolz und freuen uns, dass unser Exzellenzcluster Microbes-for-Climate (M4C) in der Exzellenzstrategie 2025 ausgewählt wurde! 🌟Wir freuen uns gemeinsam mit @unimarburg.bsky.social auf spannende #Mikrobenforschung - stay tuned ! @unimarburg.bsky.social @maxplanck.de @synmikro.bsky.social
May 22, 2025 at 3:11 PM
📢 Wir sind stolz und freuen uns, dass unser Exzellenzcluster Microbes-for-Climate (M4C) in der Exzellenzstrategie 2025 ausgewählt wurde! 🌟Wir freuen uns gemeinsam mit @unimarburg.bsky.social auf spannende #Mikrobenforschung - stay tuned ! @unimarburg.bsky.social @maxplanck.de @synmikro.bsky.social
Reposted by Schuller Jan
Pleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol
🌞🌱
rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
🌞🌱
rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
Structure, regulation and assembly of the photosynthetic electron transport chain
Nature Reviews Molecular Cell Biology - The electron transfer chain in chloroplast thylakoid membranes uses solar energy to produce NADPH and ATP, which power carbon fixation into biomass. This...
rdcu.be
May 21, 2025 at 5:40 PM
Pleased to share my very general review of Photosynthesis now published in Nature Reviews Mol Cell Biol
🌞🌱
rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
🌞🌱
rdcu.be/em1lz Hopefully a useful primer for Postgrad and undergrad students
Reposted by Schuller Jan
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
May 16, 2025 at 2:30 PM
EtfD links beta oxidation to OxPhos in mycobacteria - recent work suggests that targeting EtfD could shorten #tubeculosis treatment.
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
But how does EtfD work? And how can you assay its activity?
In his final PhD manuscript @courbongautier.bsky.social provides answers!
www.biorxiv.org/content/10.1...
Reposted by Schuller Jan
Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach https://www.biorxiv.org/content/10.1101/2025.05.15.654187v1
May 15, 2025 at 3:03 PM
Catch & Release - rapid cost-effective protein purification from plants using a DIY GFP-Trap-protease approach https://www.biorxiv.org/content/10.1101/2025.05.15.654187v1
Reposted by Schuller Jan
We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments.
🌐 afesm.foldseek.com
Read more about the work in the skeetorial
🦋 bsky.app/profile/mart...
or our preprint
📄 www.biorxiv.org/content/10.1...
🌐 afesm.foldseek.com
Read more about the work in the skeetorial
🦋 bsky.app/profile/mart...
or our preprint
📄 www.biorxiv.org/content/10.1...
May 15, 2025 at 2:03 PM
We've updated our AFESM website to now include biome filtering, allowing exploration of protein structures adapted to specific environments.
🌐 afesm.foldseek.com
Read more about the work in the skeetorial
🦋 bsky.app/profile/mart...
or our preprint
📄 www.biorxiv.org/content/10.1...
🌐 afesm.foldseek.com
Read more about the work in the skeetorial
🦋 bsky.app/profile/mart...
or our preprint
📄 www.biorxiv.org/content/10.1...
Reposted by Schuller Jan
🌱 Excited to share that I will start my lab at EPFL, CH this June supported by a @snsf.ch Starting Grant! ramakrishna.ch
We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity.
#newPI #plantsci
We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity.
#newPI #plantsci
Plant Adaptation Lab (PAL) – Situated at Institute of Environmental Engineering, EPFL, Switzerland
ramakrishna.ch
May 14, 2025 at 7:25 PM
🌱 Excited to share that I will start my lab at EPFL, CH this June supported by a @snsf.ch Starting Grant! ramakrishna.ch
We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity.
#newPI #plantsci
We are interested in plant mineral nutrition and will deep-dive into the fine-tuned mechanisms employed by plants to adapt to abiotic stresses such as salinity.
#newPI #plantsci
Reposted by Schuller Jan
Our paper: Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis is out now in PNAS! www.pnas.org/doi/10.1073/... Great collab with the labs of Ming-Yang Ho and Chris Girsiel.
Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis | PNAS
Thylakoid-free cyanobacteria are thought to preserve ancestral traits of early-evolving
organisms capable of oxygenic photosynthesis. However, and ...
www.pnas.org
May 14, 2025 at 3:44 PM
Our paper: Structure and evolution of photosystem I in the early-branching cyanobacterium Anthocerotibacter panamensis is out now in PNAS! www.pnas.org/doi/10.1073/... Great collab with the labs of Ming-Yang Ho and Chris Girsiel.