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Schallek Lab @schalleklab.bsky.social · 2d

thank you. visualization in FIJI. We use both Adaptive Optics Ophthalmoscopy and conventional confocal histology

Schallek Lab @schalleklab.bsky.social · 3d

#FluorescenceFriday
Watch to the end! Immune cells in the retina remain flat until damage is detected. Cells change their shape and dive deep in response to damage (pink cell)
@cvsuor.bsky.social @urochester.bsky.social
@flaumeye.bsky.social @uofrbme.bsky.social
elifesciences.org/articles/98662

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Reposted by Schallek Lab

Leah Johnston @leahgjohnston.bsky.social · 4d

My boss/mentor Teresa Puthussery won a MacArthur genius grant today! She shares the award with Oakland novelist Tommy Orange (read There There! It's awesome!), resource recovery chemist William Tarpeh, and 22 others. Congratulations Teresa! www.macfound.org/fellows/clas...

Teresa Puthussery

Exploring how neural circuits of the retina encode visual information for the human brain.

www.macfound.org

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Schallek Lab @schalleklab.bsky.social · 6d

Austin Roorda @roordalab.bsky.social delivering the richly deserved Boynton Lecture @optica-fvm.bsky.social
@optica.org

A tremendous journey with an incredible cast of characters that brought the world high resolution retinal imaging, Oz Vision and olo

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Schallek Lab @schalleklab.bsky.social · 8d

Congratulations to Susana Marcos @marcoslabur.bsky.social receiving the Tillyer Award @optica.org Fall Vision Meeting in #minneapolis
Introduced by Steve Burns, her mentor from postdoctoral days.
@cvsuor.bsky.social @flaumeye.bsky.social @urochestersmd.bsky.social

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Reposted by Schallek Lab

Flaum Eye Institute @flaumeye.bsky.social · 9d

Our next researcher at the Optica meeting is Jesse B. Schallek, Ph.D., who along with his lab, studies how blood flows through the vessels in the retina. They aim to understand how changes in this neural-vascular network contribute to retinal diseases and vision loss.

Flaum Researcher Jesse Schallek, Ph.D., posing in front of optical research equipment, in front of a white board and an optical imaging poster.

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Schallek Lab @schalleklab.bsky.social · 12d

Microglia (white/green) are immune cells that live in specific layers in the retina.
In response to injury, they migrate into location of damage.

doi.org/10.7554/eLif...

@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social @uofrbme.bsky.social
@urochestersmd.bsky.social

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Reposted by Schallek Lab

UR Center for Visual Science @cvsuor.bsky.social · 18d

#cvstoday 3:00 pm, Helen Wood Hall SON Auditorium, 1W-304
Knill Lecture: Daniel Wolpert, Columbia University
Computational principles underlying the learning of sensorimotor repertoires

There will be a reception immediately following the lecture in Helen Wood Hall 1W-300.

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Schallek Lab @schalleklab.bsky.social · Sep 12

#FluorescenceFriday
Strand and branch pericytes surround the vessels of the retina👁️🔬

color=depth
@flaumeye.bsky.social @urneuroscience.bsky.social @cvsuor.bsky.social @uofrbme.bsky.social @urochestersmd.bsky.social

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Reposted by Schallek Lab

Flaum Eye Institute @flaumeye.bsky.social · Sep 10

Meet Dr. Sara Patterson, a researcher at Flaum who is participating in the Emerging Vision Scientist Program.

Her lab studies how the eye communicates with the brain. This groundbreaking work is paving the way for new treatments to restore vision.

#VisionResearch #VisionRestoration #EyeHealth

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Reposted by Schallek Lab

Flaum Eye Institute @flaumeye.bsky.social · Sep 8

Thank you, Rep. Morelle, for visiting the Flaum Eye Institute to discuss and see firsthand how NEI-funded research improves patient care and drives innovation in ophthalmology. We are grateful for your support and recognition of the important role federally funded research plays.

Congressman Joe Morelle posing in a group photo with members of the Flaum Eye Institute.

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Schallek Lab @schalleklab.bsky.social · Sep 5

She did it!
Very proud to announce: the newly minted Dr. Fei Shang, PhD in Neuroscience.
Vascular insights... to what gives us sight!
@urneuroscience.bsky.social @flaumeye.bsky.social @cvsuor.bsky.social @urmed.bsky.social

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Schallek Lab @schalleklab.bsky.social · Sep 5

🧠Today🔬
PhD Thesis defense by Schallek Lab student Fei Shang!
1pm K-207 conference room, URMC.

Come to learn about how vessels nourish the eye.👁️
@cvsuor.bsky.social @urmed.bsky.social @urneuroscience.bsky.social @flaumeye.bsky.social

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Reposted by Schallek Lab

Flaum Eye Institute @flaumeye.bsky.social · Sep 3

We’re thrilled to share that our very own Matt Cavanaugh has been chosen for the Emerging Vision Scientist Program, where he will advocate for congressional support of vision research. We’re so proud of all he has accomplished so far and for his commitment to advancing vision care!

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Schallek Lab @schalleklab.bsky.social · Aug 14

#FluorescenceFriday
NEUTROPHILS are rare immune cells flowing within trillions of blood cells of the body. Using #AdaptiveOptics cameras, we directly image fluorescent neutrophils in the vessels of the eye

doi.org/10.7554/eLif...
@flaumeye.bsky.social @cvsuor.bsky.social @urneuroscience.bsky.social

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Reposted by Schallek Lab

Del Monte Institute for Neuroscience @urneuroscience.bsky.social · Aug 14

You don't have to be a scientist to think lasers are cool😎
But the 👨‍🔬 in @schalleklab.bsky.social have cool lasers
👇Lab mngr Derek Power led research using the adaptive optics camera, a laser engine, & found how immune cells in the eye respond differently when the retina is injured
👉 bit.ly/4fB7y7P

Lab manager Derek Power is photographed in his lab in the University of Rochester’s Flaum Eye Institute // photo by J. Adam Fenster / University of Rochester

Adaptive optics imaging table pioneered at the Flaum Eye Institute. // photo by J. Adam Fenster / University of Rochester

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Schallek Lab @schalleklab.bsky.social · Aug 8

Love this...
Here's a chunk of mine in peer-reviewed form 😉
@cvsuor.bsky.social @flaumeye.bsky.social

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Schallek Lab @schalleklab.bsky.social · Aug 7

thank you. yes, diagnostics is the target! tracking immune cell activity has the potential to change the way we deploy and throttle ocular therapy by modulating the immune response. Everything from uveitis, to bionic implants to gene therapy

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Schallek Lab @schalleklab.bsky.social · Aug 7

EXCITATION
At the heart of our adaptive optics camera is a laser engine. A beam of light scans the retina to image the eye with single cell resolution. @cvsuor.bsky.social
#FluorescenceFriday
#AOSLO
@urochester.bsky.social
@urochestersmd.bsky.social
@flaumeye.bsky.social
@urneuroscience.bsky.social

laser beam excites fluorescence in the eye

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Schallek Lab @schalleklab.bsky.social · Aug 1

fantastic office!

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Reposted by Schallek Lab

Del Monte Institute for Neuroscience @urneuroscience.bsky.social · Jul 29

👇3D look at adaptive optics imaging table in the @schalleklab.bsky.social This tool allowed researchers to discover that microglia, not neutrophils, a type of white blood cells, respond to photoreceptor damage in the retina

Read more: bit.ly/4mmmPvx
#URochesterResearch @flaumeye.bsky.social

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Schallek Lab @schalleklab.bsky.social · Jul 24

✨Our newest eLife paper is out!✨
👉 elifesciences.org/articles/98662
When retinal cells die, who cleans up?
Non-invasive imaging shows microglia👇 rush to help but don’t recruit neutrophils from the bloodstream. @urneuroscience.bsky.social @cvsuor.bsky.social
@elife.bsky.social #FluorescenceFriday

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Reposted by Schallek Lab

Del Monte Institute for Neuroscience @urneuroscience.bsky.social · Jul 24

#URochesterResearch by @schalleklab found that when photoreceptor cells in the retina are damaged, the brain’s immune cells respond, and neutrophils are not recruited to help despite passing through nearby blood vessels

via eLife 👉 elifesciences.org/articles/98662
@cvsuor.bsky.social

This finding has high implications for what happens to millions of Americans who suffer vision loss through loss of photoreceptors. Jesse Schallek, PhD, associate professor of Ophthalmology

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Schallek Lab @schalleklab.bsky.social · Jul 23

Thrilled to have been selected for the @cvsuor.bsky.social pilot award with additional support from @flaumeye.bsky.social.
Our collaboration with Wojtovich lab will study mitochondria survival and anatomy in the diabetic retina. @urochester.bsky.social @urochestersmd.bsky.social

UR Center for Visual Science @cvsuor.bsky.social · Jul 23

1of2) Announcing the awardees of the 2025 CVS Pilot Funds for Vision Research: Ania Majewska & Houhui Xia; Jesse Schallek & Andrew Wojtovich; David Williams, Jude Mitchell, Juliette McGregor, Sara Patterson, Bill Merigan.

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Schallek Lab @schalleklab.bsky.social · Jul 21

Dynamic Sholl analysis is a way to characterize the complexity cell process remodeling over time. Here SchallekLab is using it to show microglia dynamism in the living eye using #adaptiveoptics
#Optica @cvsuor.bsky.social @flaumeye.bsky.social @uofrbme.bsky.social
bit.ly/4kMNErh

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