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Rolando Claure @runningkidneys.bsky.social · 1d

🧪🌍 Ethical challenges in international trials:
A JASN 📑 highlights imperatives of quality, ethics, social value, validity, consent, benefit & fairness.
Focus: SGLT2i kidney trials & strategies to prevent exploitation in vulnerable populations.
🔗

https://journals.lww.com/jasn/fulltext/9900/ethical_challenges_in_international_trials.763.aspx

journals.lww.com

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Rolando Claure @runningkidneys.bsky.social · 1d

In a JAMA Open study 📑👉🏻Economic eval. in 146 ICU pts with AKI 🇨🇦:
• Standard dialysis: $251,370/patient, 7.49 QALYs
• Accelerated: $231,518/patient, 6.64 QALYs
ICER = $23,208 → Standard start is cost-effective.
🔗 doi:10.1001/jamanetworkopen.2025.35343
#AKI #Dialysis

Rolando Claure @runningkidneys.bsky.social · 1d

Cerrado un día muy ocupado con una carrera de recuperación ❤️‍🩹 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge

Rolando Claure @runningkidneys.bsky.social · 2d

🫘 In advanced #CKD, protein supplementation boosts 📈 serum albumin (+1.76 g/L) & BMI (+0.29 kg/m²) but ❌ does not significantly improve health-related quality of life (HRQOL).

🔎 17 RCTs | 5699 screened
⚠️ Bias, short duration, heterogeneity

#NephJC

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Rolando Claure @runningkidneys.bsky.social · 4d

Ñaupa Llajta 🏃🏻‍♂️ #Run4Kidneys 🫘 #850Challenge 🎗️#Cochabamba 🇧🇴

Rolando Claure @runningkidneys.bsky.social · 6d

🧬 In SGLT2-deficient 🐁 on a diabetogenic high-fat diet, kidneys had ↑ SAM → better function + ↓ NF-κB inflammation.
SAM donates methyl groups → ↑ H3K27 trimethylation → repression of inflammatory 🧬 . Blocking MAT2A removed protection.
🔗 jci.org/articles/view/188933

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Rolando Claure @runningkidneys.bsky.social · 7d

In cirrhosis, TIPS can boost kidney function & reduce ascites, but may worsen encephalopathy. MELD guides risk, yet misses post-TIPS creatinine gains.
👉 TIPS decisions should weigh kidney health, not MELD alone. #HRS #TIPS
🔗 pdfs.journals.lww.com/kidney360/99...?

Rolando Claure @runningkidneys.bsky.social · 10d

🌿 Herbal medicine: tradition… but also risk.
Some plants are nephrotoxic and can injure the kidneys.

📖 In Tropical Nephrology 2025, we review mechanisms of kidney injury linked to medicinal plants.

🔗 link.springer.com/chapter/10.1...

#Nephrology #TropicalMedicine #KidneyHealth

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Rolando Claure @runningkidneys.bsky.social · 13d

🧩 La #EII (Crohn y colitis ulcerosa) no solo afecta al intestino: puede causar complicaciones renales graves.
La #IRA vinculada a EII incluye nefritis túbulo-intersticial (farmacos/MEI), NTA y glomerulopatías como NIgA.
🔗 Más en: slanh.net/redira
#SoySLANH

RED IRA - Sociedad Latinoamericana de Nefrología e Hipertensión

La RedIRA (Red Latinoamericana de Injuria Renal Aguda), es una iniciativa del Comité ...

slanh.net

Rolando Claure @runningkidneys.bsky.social · 14d

💔 In HF patients with loop diuretic resistance, therapy depends on mechanism (DR-Loop vs DR-Distal).

📊 JASN RCT (n=103):
• ↑ Loop dose → +49 mmol Na excretion
• + Chlorothiazide → +107 mmol Na excretion

👉 Thiazide add-on more effective overall.
journals.lww.com/jasn/abstrac...

journals.lww.com

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Rolando Claure @runningkidneys.bsky.social · 15d

In a secondary analysis of 7,562 Chinese adults with eGFR 60–90, intensive BP control reduced composite CVD outcomes by 43% vs usual care, with no significant difference in kidney function decline.
📖 JAMA Netw Open jamanetwork.com/journals/jam...

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Reposted by Rolando Claure

ISNkidneycare @theisn.org · 15d

🌍 Apply for ISN Committees & Working Groups!
Make an impact on global kidney care. You can express an interest yourself or nominate a colleague.

⏳ Deadline: Oct 22, 2025, 5 p.m. CEST
👉 http://lite.spr.ly/6...

#ThisIsISN #ISNWCN

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Reposted by Rolando Claure

ISNkidneycare @theisn.org · 15d

𝗧𝗢𝗗𝗔𝗬: SLANH-ISN webinar: "Fluids in AKI: New Paradigms."

🗣️ @runningkidneys.bsky.social, Lilia Rizo, Alejandro Ferreiro, Jonathan Chavez
👤 Olynka Vega
🗓️ October 1
🕓 7 pm Panama time
🔗 Free registration: bit.ly/slanh01octubre

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Rolando Claure @runningkidneys.bsky.social · 18d

Un muy buen 4to lugar en mi categoría #SendaDelSol ☀️ 🏃🏻 🔟 Km #Run4Kidneys 🫘 #850Challenge 🎗️

Rolando Claure @runningkidneys.bsky.social · 20d

Metabolic dysfunction–associated kidney disease (MDAKD) links metabolic syndrome & CKD. Prevention must include early risk assessment, lifestyle change & novel therapies (SGLT2i, GLP-1RA).
👉 www.kidney-international.org/article/S008...

#KidneyHealth #CKD #MetabolicDisease

Rolando Claure @runningkidneys.bsky.social · 21d

✅ PROGRAMA EDUCATIVO ANUAL DIALOGANDO CON EXPERTOS
👉 SLANH + ISN

🚀 Tema: FLUIDOS EN IRA: NUEVOS PARADIGMAS

🗓️ Miércoles 01 de octubre de 2025
🕖 19:00 Hs: 🇵🇦 PA
✅ REGISTRATE AQUI: bit.ly/slanh01octubre

🌐 slanh.net
#slanh #soynefrólogo #soyslanh

Rolando Claure @runningkidneys.bsky.social · 21d

New study: In cirrhosis patients with AKI, a tubular secretion score helps differentiate ATN from PRA/HRS.
Lower secretion = ATN risk ↑ (OR 0.34 per SD; AUC 0.73).
Promising tool for diagnosis & prognosis.

journals.lww.com/cjasn/abstra...

#AKI #Hepatology

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Rolando Claure @runningkidneys.bsky.social · 23d

AI 🤖 is reshaping #nephrology: from patient summaries & pathology to dialysis optimization, AKI/CKD diagnosis, and transplant care.
@ASN_Kidney is preparing a position paper on responsible AI use, with major focus at #KidneyWk25 in Houston.
www.kidneynews.org/view/journal...

https://www.kidneynews.org/view/journals/kidney-news/17/9/article-p1_2.xml

www.kidneynews.org

Rolando Claure @runningkidneys.bsky.social · 28d

📊 Of 1,226 studies screened, 24 RCTs (n=3,906) on HDF vs HD were analyzed.
🔹Most 4h, 3x/wk, post-dilution (15–24L effluent). Symptoms studied: cramps, fatigue, GI, itch, restless legs, sleep.
📑 Meta-analysis: HDF did not improve these vs HD. #HDF #HD

www.kidneymedicinejournal.org/article/S259...

The Impact of Hemodiafiltration Versus Hemodialysis on Uremic Symptoms, Physical Function: A Systematic Review and Meta-analysis of Randomized Controlled Trials

Uremic symptoms and frailty in kidney failure may be driven by the accumulation of uremic toxins that are variably cleared by dialysis. We conducted a systematic review and meta-analysis of…

www.kidneymedicinejournal.org

Rolando Claure @runningkidneys.bsky.social · Sep 14

#CochaTrail 21K ✅🏃🏻‍♂️ Stunning #Cochabamba views ⛰️ at 2890 m above sea level! A tough and demanding circuit 😅 #Run4Kidneys 🫘 #850Challenge

Rolando Claure @runningkidneys.bsky.social · Sep 13

📉 In adults ≥65y, a systematic review (13 studies, >100k participants) found no difference in mortality risk prediction between CKD-EPI & older-age–validated eGFR equations.
Cystatin C–based eGFR showed stronger links with ☠️ than creatinine-based.
🔗 www.kidneymedicinejournal.org/article/S259...

A Systematic Review Comparing the Prognostic Role of eGFR According to CKD-EPI and Older Age Validated Equations in Older Adults

Assessing the clinical relevance of reduced estimated glomerular filtration rate (eGFR) in older adults is challenging as GFR naturally declines with age and not all equations, including the Chronic…

www.kidneymedicinejournal.org

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Rolando Claure @runningkidneys.bsky.social · Sep 12

FDA has approved the first human clinical trials for pig-to-human kidney transplants—a major leap in xenotransplantation that could help solve the severe organ shortage and offer hope to millions waiting for transplants. #OrganTransplantation

www.cnn.com/2025/09/08/h...

Pig kidney transplants take a step forward with approval of human trials | CNN

Scientists continue to make progress with research on how well pig organs might perform in humans, and now they’re ready for the next step: larger-scale clinical trials.

www.cnn.com

Reposted by Rolando Claure

ISNkidneycare @theisn.org · Sep 11

𝗧𝗢𝗗𝗔𝗬: Grand Rounds in Transplant Nephrology – an ISN-TTS Sister Transplant Centers Initiative.

🗣️ Noot Sengthavisouk, Surasak Kantachuvesiri, Nuttapon Arpornsujaritkun
👤 Robert Freercks
🗓️ September 11
🕓 2 pm CEST
🔗 Free registration: http://lite.spr.ly/6...

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Rolando Claure @runningkidneys.bsky.social · Sep 10

🧪 New in #Kidney360: “Active” urine sediment (dysmorphic RBCs, casts) strongly predicts proliferative GN.
In 795 biopsies: sensitivity 82%, specificity 74%.
Simple, low-cost microscopy remains a powerful guide in #Nephrology.

🔗 journals.lww.com/kidney360/ab...

https://journals.lww.com/kidney360/abstract/9900/value_of__active__urine_sediment_examination_in.735.aspx

journals.lww.com

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Rolando Claure @runningkidneys.bsky.social · Sep 10

✨🙌 Damos la bienvenida a la nueva Junta Directiva SLANH 2025–2027. Felicitamos a sus integrantes y les deseamos el mayor de los éxitos en esta gestión que fortalece la unidad, la ciencia y la nefrología en América Latina. 🌎🩺💙 #SLANH #SaludRenal