@robineclee.bsky.social
Associate Professor, University of Pittsburgh. Department of Computational and Systems Biology. Lab of Cellular Dynamics and Molecular Circuits https://csbweb.csb.pitt.edu/Faculty/lee/
Our “zoo experiment” in Cell Reports @cellpress.bsky.social shows that extracellular cytokine molecules are encoded by surface receptors as quantized signaling units, independent of ligand affinity. A new principle for how cells sense and interpret their environment. www.cell.com/cell-reports...
NEMO recruitment at single cytokine-receptor complexes shows quantized dynamics independent of ligand affinity
Kim et al. leverage natural variation in IL-1β affinity across species to show that
while ligand affinity sets activation thresholds, each IL-1 receptor signaling complex
outputs a fixed, quantized bu...
www.cell.com
December 3, 2025 at 1:45 PM
Our “zoo experiment” in Cell Reports @cellpress.bsky.social shows that extracellular cytokine molecules are encoded by surface receptors as quantized signaling units, independent of ligand affinity. A new principle for how cells sense and interpret their environment. www.cell.com/cell-reports...
Reposted
In the complex world inside our bodies, timing can be everything.
A new study from Steven Smeal and Robin E.C. Lee reveals the timing of molecular signals can change how cells respond to their environment, with implications for cancer treatment and drug discovery.
Read more: rdcu.be/ezTxF
A new study from Steven Smeal and Robin E.C. Lee reveals the timing of molecular signals can change how cells respond to their environment, with implications for cancer treatment and drug discovery.
Read more: rdcu.be/ezTxF
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
August 15, 2025 at 4:15 PM
In the complex world inside our bodies, timing can be everything.
A new study from Steven Smeal and Robin E.C. Lee reveals the timing of molecular signals can change how cells respond to their environment, with implications for cancer treatment and drug discovery.
Read more: rdcu.be/ezTxF
A new study from Steven Smeal and Robin E.C. Lee reveals the timing of molecular signals can change how cells respond to their environment, with implications for cancer treatment and drug discovery.
Read more: rdcu.be/ezTxF
In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
August 13, 2025 at 3:29 PM
In @natcomms.nature.com, we used robot-controlled cytokine pulses and imaging single receptor complexes and TF dynamics reveal that repeat, dose-conserving stimulation prolongs NEMO/IKK activation and shifts NF-κB dynamics via chromatin remodeling, enabling accurate single-cell models rdcu.be/ezTxF
Thrilled to see our latest work online in Nature Communications rdcu.be/ezTxF! Congratulations and thanks to
@cmupittcompbio.bsky.social
PhD student Steven Smeal and all the co-authors for their critical contributions.
@cmupittcompbio.bsky.social
PhD student Steven Smeal and all the co-authors for their critical contributions.
Time-varying stimuli that prolong IKK activation promote nuclear remodeling and mechanistic switching of NF-κB dynamics
Nature Communications - Cells rely on limited numbers of transmembrane receptors to process signals from dynamic microenvironments. Using microfluidics and endogenous reporters, the authors track...
rdcu.be
August 8, 2025 at 2:50 PM
Thrilled to see our latest work online in Nature Communications rdcu.be/ezTxF! Congratulations and thanks to
@cmupittcompbio.bsky.social
PhD student Steven Smeal and all the co-authors for their critical contributions.
@cmupittcompbio.bsky.social
PhD student Steven Smeal and all the co-authors for their critical contributions.
When a bovine cytokine talks to a human cell: Lessons from cross-species signaling experiments. 😊 🐱 🐰 🐁 🐀 🐄
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
April 22, 2025 at 9:07 PM
When a bovine cytokine talks to a human cell: Lessons from cross-species signaling experiments. 😊 🐱 🐰 🐁 🐀 🐄
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...