Lightnews — Scholar-powered news

Reposted by Robert Krautz

Ralph Janik @ralphjanik.com · 24d

“Harvard geneticist David Reich said … increasingly sophisticated analysis of genetic material made possible by technological advances shows that virtually everyone came from somewhere else, and everyone’s genetic background shows a mix from different waves of migration that washed over the globe.”

Pure bloodlines? Ancestral homelands? DNA science says no. — Harvard Gazette

Geneticist explains recent analyses made possible by tech advances show human history to be one of mixing, movement, displacement.

news.harvard.edu

22 180 450

Reposted by Robert Krautz

Jan Żylicz @jzylicz.bsky.social · 26d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

6 22 67

Robert Krautz @robertkrautz.bsky.social · 26d

Guess, I'll have a coffee then.

Robert Krautz @robertkrautz.bsky.social · 28d

Beautiful pictures indeed. What is your weapon of choice: Illustrator or Inkscape?

1 1

Robert Krautz @robertkrautz.bsky.social · 29d

Craft House Prague?

Reposted by Robert Krautz

Navin B. Ramakrishna @navinbr.bsky.social · Sep 12

Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/...
From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social

Emerging principles and models of human primordial germ cell development

Summary: This Review examines recent insights into early human germ cell development and how these regulatory principles guide stem cell-derived models aiming to reconstitute human gametogenesis in vi...

journals.biologists.com

1 7 13

Robert Krautz @robertkrautz.bsky.social · Jul 29

“Nurses should be at the very top of our social hierarchy but we live in a world where it’s just the opposite,”

www.theguardian.com/film/2025/ju...

The shocking hit film about overworked nurses that’s causing alarm across Europe

A Swiss film about a nurse pushed to her limits one night is being praised for the picture it paints of treacherously underfunded healthcare. The director talks about the ‘heart-pounding’ story that i...

www.theguardian.com

1

Reposted by Robert Krautz

Geula Hanin @geula.bsky.social · Jul 24

🚨 I’m looking for two enthusiastic scientists to join our team at Cambridge to explore the molecular mechanisms of lactation, early nutrition, and their long-term impact on health.

Apply here:
👉 RA: www.jobs.cam.ac.uk/job/51988/
👉 Postdoc: www.jobs.cam.ac.uk/job/51984/

Please share 🔬👩‍🔬

Research Assistant (Fixed Term) - Job Opportunities - University of Cambridge

Research Assistant (Fixed Term) in the Department of Physiology, Development and Neuroscience at the University of Cambridge.

www.jobs.cam.ac.uk

17 22

Reposted by Robert Krautz

Yad Ghavi-Helm @yghavi.bsky.social · Jul 23

📢 We are recruiting!
Several projects are available and can be tailored to the candidate's profile. Most include confocal imaging/spatial OMICs technologies.
Please share and RT 🙏

1 36 28

Reposted by Robert Krautz

Oded Rechavi @odedrechavi.bsky.social · Jul 23

Tomorrow at 19:30 a huge demonstration in Tel Aviv - The Israeli Academia demands to end the war NOW. These horrors are unbearable and must stop.

1 24 110

Robert Krautz @robertkrautz.bsky.social · Jul 19

“Simple” experiment, but crucial point: we won’t identify all gene regulatory mechanisms underlying disease by simply looking at healthy tissues / cell lines under norm conditions.

Robert Krautz @robertkrautz.bsky.social · Jul 19

Is this consciously ambiguous? After all he is the Lord of the Dance. 😉

1

Robert Krautz @robertkrautz.bsky.social · Jul 19

I second this. Such additional data is great for documentation purposes, but in order for someone (us) to make a systematic change to the publishing model, such stats need to incite a whole field to want to change. As long as authors (us) accept 3 y & ~10 m publishing time, no change will occur.

1 3

Robert Krautz @robertkrautz.bsky.social · Jul 14

I’m the dNTPs and my wife the polymerase. After two cycles, no one cares about where everything started or ends, only that you work together to string a sequence of meaning together.

8

Robert Krautz @robertkrautz.bsky.social · Jul 8

So you basically print out the info from the background signal in combination with your actual peak score, so that one could use the former to e.g., color-code the latter based on CNVs?

1

Reposted by Robert Krautz

Mike Robson @drmrobson.bsky.social · Jul 8

Calling all aspiring Postdocs! One extra week to apply to join our exciting HFSP-funded project to uncover how chromatin moves to function.

Deadline July 15th.

www.mdc-berlin.de/career/jobs/...

16 15

Reposted by Robert Krautz

Jeff Vierstra @jeffvierstra.bsky.social · Jul 8

We have created a new DNase I- & ATAC-seq peak caller that uses an adaptive background model that controls for copy number variation & aneuploidy. It performs a per-nucleotide test (+FDR correction) and is very fast. Please try it out and give us feedback!

github.com/vierstralab/...

GitHub - vierstralab/hotspot3: A chromatin accessibility peak caller with an adaptive background model

A chromatin accessibility peak caller with an adaptive background model - vierstralab/hotspot3

github.com

2 10 42

Robert Krautz @robertkrautz.bsky.social · Jul 8

Naive question: if you can control for CNVs & aneuploidies, can you so also highlight / annotate peaks identified to be detected in such genome regions. That might be really exciting from a biological point, to contrast peaks inside vs outside?

1

Robert Krautz @robertkrautz.bsky.social · Jul 7

Couldn’t agree more, Aarhus is amazing. The university is also visually stunning, great architecture.

2

Robert Krautz @robertkrautz.bsky.social · Jul 7

Aarhus centrum, Østergade, I would say. Close to the main shopping street, Søndergade.

1 1

Robert Krautz @robertkrautz.bsky.social · Jul 7

Not stalking you, just know my Berlin. 😉 Half an A, a “l” and a “b” are enough.

1 1

Robert Krautz @robertkrautz.bsky.social · Jul 7

Albrechtstrasse, Berlin. Close to the Charité?

1 1

Robert Krautz @robertkrautz.bsky.social · Jul 4

Several conferences I attended used bullet / lightning talks introducing (again selected only) posters in 1-2 min. Perfect for getting the feeling of having presented, standing in front of an audience & acknowledgement on the presenters side & a decent overview in a calm environment for audiences.

1 1

Reposted by Robert Krautz

Evgeny Kvon @evgenykvon.bsky.social · Jul 2

Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

Range extender mediates long-distance enhancer activity - Nature

The REX element is associated with long-range enhancer–promoter interactions.

www.nature.com

10 90 190

Robert Krautz @robertkrautz.bsky.social · Jul 2

Is Leptomycin volatile / unstable that warrants such packaging? Should Sigma not also embark on more green packaging solutions?

1