Author | Lightnews

Renal and Urology News @renalurologynews.bsky.social · 1d

A combination of belzutifan, pembrolizumab, and lenvatinib showed encouraging results as first-line treatment for advanced RCC in an early phase trial. Phase 3 trial data are pending.
www.renalandurologynews.com/news/triplet... #kidneycancer

Triplet Therapy for ccRCC Using Belzutifan, Pembrolizumab, Lenvatinib Shows Potential

A substudy of the phase 1/2 KEYMAKER-U03 trial tested novel pembrolizumab-based triplet regimens for first-line treatment of advanced clear cell renal cell carcinoma (ccRCC).

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Renal and Urology News @renalurologynews.bsky.social · 2d

GLP-1 RAs are not linked to increased risks for most serious GI or hepatobiliary outcomes compared with oral diabetes medications.
www.renalandurologynews.com/news/glp1ras... #diabetes

GLP-1RAs Do Not Have Worse GI Safety Than Other Diabetes Medications

GLP-1 RAs are not linked to an increased risk for serious GI or hepatobiliary outcomes, compared with other diabetes medications.

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Renal and Urology News @renalurologynews.bsky.social · 3d

Based on IIEF scores, mMicro-energy treatments appear to have long-lasting therapeutic effect in men with erectile dysfunction.
www.renalandurologynews.com/news/micro-e...

Micro-Energy Treatments Can Sustain Erectile Function Improvement for Up to 1 Year

Micro-energy treatments include low-intensity extracorporeal shockwave therapy, low-intensity pulsed ultrasound, and electromagnetic fields.

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Renal and Urology News @renalurologynews.bsky.social · 4d

Low-dose pyridostigmine is an effective treatment for men with underactive bladder who undergo TURP for BPH with BOO, trial findings suggest.
www.renalandurologynews.com/news/pyridos...

Pyridostigmine Enhances Underactive Bladder Recovery After TURP for BPH With BOO

Approximately one-third of patients with enlarged prostates (BPH) and bladder outlet obstruction have detrusor underactivity leading to TURP failure.

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Renal and Urology News @renalurologynews.bsky.social · 5d

Extended dissection did not improve recurrence-free or overall survival, but it may have a bladder cancer-specific survival benefit possibly because it removes micrometastases.
www.renalandurologynews.com/news/extende...

Extended Lymph Node Dissection Improves Cancer-Specific Survival After Cystectomy

The study results reflect the effect of surgery with lymph node dissection alone in patients with high-grade invasive bladder cancer.

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Renal and Urology News @renalurologynews.bsky.social · 10d

The transmission electron microscopy (TEM)-based artificial intelligence tool is the first clinically applicable AI system for the diagnosis and quantitative analysis of glomerular diseases.
www.renalandurologynews.com/news/ai-syst... #kidneydisease

AI System Enhances Glomerular Disease Diagnosis Accuracy and Efficiency

Investigators developed and tested AI-driven electron microscopy analysis to improve diagnosis of kidney glomerular diseases.

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Renal and Urology News @renalurologynews.bsky.social · 15d

Patients who undergo single-port robotic prostate or kidney surgery tend to have less blood loss and postoperative pain and shorter hospital stays compared with patients undergoing multi-port robotic surgery.
www.renalandurologynews.com/news/single-... #surgery

Single-Port Robotic Prostate or Kidney Surgery Offers Perioperative Advantages

Single-port robotic surgery through a single small incision may have advantages over multi-port surgery for postoperative recovery.

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Renal and Urology News @renalurologynews.bsky.social · 17d

Long-term data from a prospective phase 2 trial show neoadjuvant cisplatin-based chemotherapy before nephroureterectomy provides durable survival benefits in high-risk, nonmetastatic UTUC.
www.renalandurologynews.com/news/urothel... #bladdercancer

Neoadjuvant Chemo Improves Long-Term Survival Outcomes in High-Risk UTUC

Long-term trial findings support use of neoadjuvant chemotherapy in patients with high-risk localized upper tract urothelial carcinoma (UTUC).

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Renal and Urology News @renalurologynews.bsky.social · 18d

Cytopenias are linked with worse response to anemia treatment and appear to be a marker of worse survival among the hemodialysis population. www.renalandurologynews.com/news/hemodia... #anemia

Study IDs Predictors of Cytopenias Tied With ESA Resistance, Early Death in Hemodialysis

Many patients undergoing maintenance hemodialysis have anemia, leukopenia, or thrombocytopenia with few predictors. Investigators identified predictive factors for varying degrees of cytopenia among t...

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Renal and Urology News @renalurologynews.bsky.social · 19d

SBRT after radical prostatectomy without ADT improves prostate cancer BCRFS and appears to be a viable alternative to conventionally fractionated radiation therapy, a phase 2 trial finds.
www.renalandurologynews.com/news/prostat... #prostatecancer

SBRT Without ADT Reduces Post-RP Prostate Cancer Biochemical Recurrence Risk

A phase 2 trial tested the efficacy of local stereotactic body radiation therapy (SBRT) use after radical prostatectomy.

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Renal and Urology News @renalurologynews.bsky.social · 22d

The phase 3 NRG GU-005 trial did not show a DFS benefit for SBRT vs IMRT in intermediate-risk prostate cancer, but SBRT decreased rectal toxicity.
www.renalandurologynews.com/news/sbrt-mh... #prostatecancer

SBRT vs MH-IMRT for Intermediate-Risk Prostate Cancer Offers Better QoL, Similar DFS

The phase 3 NRG Oncology GU005 trial tested SBRT vs MH-IMRT radiation for intermediate-risk prostate cancer for disease control and quality of life.

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Renal and Urology News @renalurologynews.bsky.social · 23d

Biosensors may turn into a new clinician assistant by providing earlier detection of kidney-relevant biomarkers, such as creatinine, urea, and electrolytes in peripheral body fluids.

Read our latest feature: www.renalandurologynews.com/features/imp...

Implantable Biosensors and Wearables for Managing Kidney, Urologic Diseases

Implantable biosensors and wearable technologies have the potential to enable continuous, real-time monitoring of kidney and urologic health.

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Renal and Urology News @renalurologynews.bsky.social · 24d

MMF induction is a viable alternative to cyclophosphamide for treating mixed proliferative lupus nephritis in children.
www.renalandurologynews.com/news/pediatr... #lupus

Mycophenolate Noninferior to Cyclophosphamide for Pediatric Lupus Nephritis Induction

A randomized trial tested oral mycophenolate vs intravenous cyclophosphamide as lupus nephritis induction treatment in children.

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Renal and Urology News @renalurologynews.bsky.social · 24d

Steroids can be avoided for up to 7 years in low-risk kidney transplant recipients without increasing acute graft rejection.
www.renalandurologynews.com/news/steroid... #kidneytransplant

Steroid-Free Kidney Transplant Immunosuppression Leads to Good, Long-Term Outcomes

Minimizing steroids in immunosuppression protocols to reduce toxicity is a major goal of recent kidney transplant research.

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Renal and Urology News @renalurologynews.bsky.social · 25d

Hypertensive CKD deaths disproportionally affected Black and Hispanic adults and patients residing in the Southern US.
www.renalandurologynews.com/news/hyperte... #kidneydisease

Hypertensive CKD Deaths Rising in the United States

In the United States, deaths from hypertensive chronic kidney disease (CKD) have risen over the past 25 years.

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Renal and Urology News @renalurologynews.bsky.social · 26d

Calcitriol added to RAS blockade further reduced proteinuria and slowed kidney function decline over 12 months in patients with IgA nephropathy.
www.renalandurologynews.com/news/calcitr... #nephropathy

Calcitriol Reduces Proteinuria in Patients With IgA Nephropathy

A randomized trial tested the potential additive benefit of active vitamin D in reducing proteinuria in patients with IgA nephropathy.

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Renal and Urology News @renalurologynews.bsky.social · 26d

Calcitriol added to RAS blockade further reduced proteinuria and slowed kidney function decline over 12 months in patients with IgA nephropathy.
www.renalandurologynews.com/news/calcitr... #kidneydisease

Calcitriol Reduces Proteinuria in Patients With IgA Nephropathy

A randomized trial tested the potential additive benefit of active vitamin D in reducing proteinuria in patients with IgA nephropathy.

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Renal and Urology News @renalurologynews.bsky.social · 29d

Less than 14% of EBV-seronegative children received a kidney transplant from a seronegative deceased donor.
www.renalandurologynews.com/news/pediatr... #kidneytransplant

Donor-Derived Epstein-Barr Virus Frequent, Harmful for Pediatric Kidney Transplant Recipients

Children undergoing kidney transplantation are susceptible to serious complications if exposed to Epstein-Barr virus infection.

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Renal and Urology News @renalurologynews.bsky.social · Sep 25

New #FDA approval: Keytruda Qlex must be administered by a health care provider. www.renalandurologynews.com/news/keytrud...

Keytruda Qlex, an SC Formulation of Pembrolizumab, Gets FDA Approval

The FDA has approved Keytruda Qlex for patients aged 12 years and older across 38 solid tumor indications.

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Renal and Urology News @renalurologynews.bsky.social · Sep 25

The GSM guideline gives 26 pragmatic statements for rapid implementation by clinicians to improve overall patient outcomes.

Read our latest feature:
www.renalandurologynews.com/features/tre...

How to Treat Genitourinary Syndrome of Menopause

Low-dose vaginal estrogens, available in various applications such as creams, tablets, inserts, and rings, are the mainstay of GSM treatment.

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Renal and Urology News @renalurologynews.bsky.social · Sep 24

BCG unresponsiveness was among the factors predicting residual extravesical disease in surgery patients who received neoadjuvant cisplatin-based chemotherapy.
www.renalandurologynews.com/news/bladder... #bladdercancer

Residual Extravesical Disease Predictors Identified After MIBC Cisplatin-Based NAC

Cisplatin-based neoadjuvant chemotherapy typically improves outcomes for patients with muscle-invasive bladder cancer, but not all groups benefit.

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Renal and Urology News @renalurologynews.bsky.social · Sep 24

Socioeconomic, regional, and racial disparities are among the relevant factors behind CKD mortality in SLE.
www.renalandurologynews.com/news/chronic... #lupus

CKD Mortality Rising Among US Patients With Systemic Lupus Erythematosus

Chronic kidney disease (CKD) is a frequent contemporary concern and a major cause of death among patients in the United States with systemic lupus erythematosus (SLE).

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Renal and Urology News @renalurologynews.bsky.social · Sep 23

Findings from studies over 30 years support the integration of chemotherapy and immunotherapy into standard MIBC treatment.
www.renalandurologynews.com/news/muscle-... #bladdercancer

Muscle-Invasive Bladder Cancer Treatment Sequences Compared

Investigators conducted a network meta-analysis of phase 3 trials to rank muscle-invasive bladder cancer treatments.

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Renal and Urology News @renalurologynews.bsky.social · Sep 22

Iscalimab reduced proteinuria over 24 weeks in patients with active LN but some concerning adverse events were reported.
www.renalandurologynews.com/news/lupus-n... #lupus

Iscalimab Reduces Proteinuria in Active Proliferative Lupus Nephritis

A phase 2 trial tested an anti-CD40 monoclonal antibody in patients with moderately active lupus nephritis.

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Renal and Urology News @renalurologynews.bsky.social · Sep 19

Patients typically experience a modest mean 8.1 mL/min/1.73 m2 decrease in the eGFR after cisplatin treatment.
www.renalandurologynews.com/news/chronic... #kidneycancer

Simple Model Predicts Chronic Kidney Disease After Cisplatin Treatment

Cisplatin treatment is associated with a predictable decrease in kidney function.

www.renalandurologynews.com

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