Pese al revisionismo histórico y el discurso de la extrema derecha, el desmontaje de la legislación de la dictadura ha llevado a España a la época de mayor libertad y progreso

Bacterial STI prevention by doxycycline postexposure prophylaxis (DoxyPEP) in men who have sex with men (MSM) has raised concerns about antimicrobial drug resistance (AMR). We studied the impact of DoxyPEP on Neisseria gonorrhoeae (GC) AMR in the ANRS 174 DOXYVAC trial.MethodsMSM on HIV PrEP randomized to DoxyPEP (n= 362) or no-PEP (n=183) arms were tested for GC at baseline and every three months thereafter, by culture and NAAT. MICs were determined with Etest (Biomerieux) and interpreted according to EUCAST guidelines. We performed whole-genome sequencing and/or PCR sequencing on GC isolates and NAAT-positive samples, using Fisher’s exact tests for comparisons.ResultsFrom January 2021 to February 2023, MICs were determined for 78 GC isolates, and 233 NAAT only GC-positive samples were analysed to identify the molecular determinants of resistance. All GC isolates were resistant to tetracycline with a significant increase in rate of high-level tetracycline resistance mediated by the tetM gene in the DoxyPEP arm than in the no-PEP arm (35.5 vs. 12.5%, respectively p=0.043). The MICs of ceftriaxone, fluoroquinolones and azithromycin were similarly distributed in the DoxyPEP and no-PEP arms. All GC isolates were susceptible to ceftriaxone and cefixime, but isolates with decreased susceptibility to cefixime linked to the mosaic penA34.007 allele were more frequent in the DoxyPEP arm than the no-PEP arm (32.3% vs 10.0%, respectively p=0.033).ConclusionsDoxyPEP use was associated with a significant increase in high-level tetracycline resistance and decreased susceptibility to cefixime in GC. AMR should therefore be closely monitored when using this strategy.

Vascular graft or endograft infection (VGEI) is a severe complication requiring a multidisciplinary approach combining surgery and antimicrobial therapy. This study aimed to develop expert consensus o...

Antimicrobial resistance (AMR) forms a major threat to human medicine, which is fuelled by antibiotic (over)use. Urinary tract infections (UTI) are responsible for a large part of antibiotic prescript...

Antimicrobial resistance (AMR) is an intractable problem that has the potential to significantly limit advances in human health. Recently, the UN General Assembly (UNGA) High-Level Statement on AMR de...

Mañana se reúne el Comité Técnico dentro de la Comisión de Recursos Humanos para decidir si reconoce Infecciosas como especialidad o como área de capacitación específica (ACE).

Implementation of a community-based fast-referral program for acute/recent HIV led to one third of new diagnoses being captured early, significantly reduci

Researchers say that the number of infections for this time of year is unusual.

This cohort study investigates if use of β-lactam antibiotics for surgical prophylaxis is associated with fewer surgical site infections across the surgical specialties.

Nadie duda de que volveremos a sufrir una pandemia. La pregunta ahora es doble: cuándo llegará y cómo de preparada estará España para afrontarla en las mejores condiciones posibles

The duration of antimicrobial treatment is currently a hot topic in the field of infectious diseases. For decades, the prevailing belief was that long treatments were essential to prevent relapses. Th...

Candidemia is a severe complication in critically ill and immunocompromised patients, and is associated with high morbidity and mortality. While early fungal clearance may improve outcomes, the associ...

Candidemia is a severe complication in critically ill and immunocompromised patients, and is associated with high morbidity and mortality. While early fungal clearance may improve outcomes, the associ...

Abstract. Invasive fungal diseases, particularly among immunocompromised patients, represent a growing clinical challenge due to limited therapeutic option