Phill Stansfeld
@pstansfeld.bsky.social
Professor of Computational Biochemistry. School of Life Sciences & Department of Chemistry, University of Warwick. Molecular Modeller of Membrane Proteins, Bacterial Biogenesis & Antimicrobial Resistance.
Reposted by Phill Stansfeld
Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking.
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
Structural characterization of the YbbAP-TesA ABC transporter identifies it as a lipid hydrolase complex that extracts hydrophobic compounds from the bacterial inner membrane
In E.coli, three of the four Type VII ABC transporter systems have been structurally characterized. This study solves cryo-EM structures of the fourth Type VII ABC system, YbbAP-TesA, and suggests tha...
dx.plos.org
November 26, 2025 at 12:46 PM
Type VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking.
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli.
dx.plos.org/10.1371/jour...
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:56 PM
Super collaboration with @raffaeleieva.bsky.social and @fronzeslab.bsky.social on the LptDEMY complex.
Reposted by Phill Stansfeld
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Nature Communications - The asymmetric distribution of lipopolysaccharide (LPS) on the surface of the bacterial outer membrane is essential and crucial for antibiotic resistance. Here, authors...
rdcu.be
November 24, 2025 at 4:08 PM
rdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
Kat Blow has developed CCD2MD, a suite of packages for preparing co-folded outputs for MD simulations.
Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too.
pubs.acs.org/doi/full/10....
github.com/keb721/ccd2md
Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too.
pubs.acs.org/doi/full/10....
github.com/keb721/ccd2md
CCD2MD: A Suite of Packages for Preparing Co-Folded Outputs for Molecular Dynamics Simulations
Protein–lipid interactions play a crucial role in the stability and function of membrane proteins. While experimental approaches to characterize these interactions in a native-like membrane environmen...
pubs.acs.org
November 12, 2025 at 11:53 AM
Kat Blow has developed CCD2MD, a suite of packages for preparing co-folded outputs for MD simulations.
Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too.
pubs.acs.org/doi/full/10....
github.com/keb721/ccd2md
Created for protein–lipid interactions in integral membrane proteins, it also works for peripheral and lipid-anchored proteins too.
pubs.acs.org/doi/full/10....
github.com/keb721/ccd2md
Biochemical Society's Membrane Protein Conference
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel
- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...
#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel
- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...
#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social
October 24, 2025 at 8:07 AM
Biochemical Society's Membrane Protein Conference
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel
- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...
#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social
7–9 April 2026
Birmingham, UK | Leonardo Royal Hotel
- Abstracts welcome for talks & posters
- Bursaries available!
- Register & submit here:
www.eventsforce.net/biochemsoc/f...
#MembraneProteins #CallForAbstracts @biochemsoc.bsky.social
Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉
October 4, 2025 at 1:34 PM
Just in time for Becca’s thesis submission, their paper on MreB membrane interactions is published in @biophysj.bsky.social: www.cell.com/biophysj/ful... 🎉
Fantastic WEHeraeus symposium at the Bad Honnef Physikzentrum, perfectly organised by @djanuliene.bsky.social and @arnemoeller.bsky.social. Thank you for the invitation.
September 17, 2025 at 3:12 PM
Fantastic WEHeraeus symposium at the Bad Honnef Physikzentrum, perfectly organised by @djanuliene.bsky.social and @arnemoeller.bsky.social. Thank you for the invitation.
Józef Lewandowski and I have a JPIAMR-funded Postdoctoral position available.
We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations.
The successful applicant will be part of a larger consortium of academic and industrial partners.
bit.ly/3TVs74O
We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations.
The successful applicant will be part of a larger consortium of academic and industrial partners.
bit.ly/3TVs74O
Research Fellow (110633-0625) - University of Warwick
Title: Research Fellow (110633-0625). Application Deadline: . Position Type: Fixed Term
warwick-careers.tal.net
July 7, 2025 at 11:59 AM
Józef Lewandowski and I have a JPIAMR-funded Postdoctoral position available.
We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations.
The successful applicant will be part of a larger consortium of academic and industrial partners.
bit.ly/3TVs74O
We are seeking a candidate to study antibiotic interactions with bacterial membranes using MD Simulations.
The successful applicant will be part of a larger consortium of academic and industrial partners.
bit.ly/3TVs74O
Also a couple of back-to-back @natcomms.nature.com papers with @chelseabrown.bsky.social on Mycobacterial enzymes in collaboration with the Mancia lab et al.: doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE - Nature Communications
Here the authors investigate of the structural basis of substrate recognition and the catalytic mechanism of the mannosyltransferase PimE, which is crucial for the biosynthesis of phosphatidyl-myo-ino...
doi.org
July 7, 2025 at 11:33 AM
Also a couple of back-to-back @natcomms.nature.com papers with @chelseabrown.bsky.social on Mycobacterial enzymes in collaboration with the Mancia lab et al.: doi.org/10.1038/s414...
doi.org/10.1038/s414...
doi.org/10.1038/s414...
New Paper with @deanelab.bsky.social: www.nature.com/articles/s41...
Conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis - Nature Communications
Gangliosides are bioactive lipids important for neuronal cell function. Here, authors reveal the dynamic structure of the ganglioside synthetic enzyme B4GALNT1 and demonstrate how it inserts into memb...
www.nature.com
July 7, 2025 at 11:28 AM
New Paper with @deanelab.bsky.social: www.nature.com/articles/s41...
New paper out, with a contribution from Dom Gurvic and I; led by Andy Lovering and @lalouxlab.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A porin-like protein used by bacterial predators defines a wider lipid-trapping superfamily
Nature Communications - This study reveals that an outer membrane protein from the predator Bdellovibrio bacteriovorus forms a pentameric assembly that traps a lipid monolayer within. This allows...
www.nature.com
July 7, 2025 at 10:00 AM
New paper out, with a contribution from Dom Gurvic and I; led by Andy Lovering and @lalouxlab.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Phill Stansfeld
Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...
Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization
doi.org
March 27, 2025 at 9:31 AM
Check out our new paper with Michael Landreh, @pstansfeld.bsky.social and others in @elife.bsky.social : Engineering cardiolipin binding to an artificial membrane protein reveals determinants for lipid-mediated stabilization doi.org/10.7554/eLif...
Reposted by Phill Stansfeld
You or someone you know interested in cell envelopes and getting a PhD? Come join me warwick.ac.uk/fac/cross_fa... or have a look at some of the other fantastic projects on offer @uni-of-warwick.bsky.social
Dr Melissa Webby
Dr Melissa Webby
warwick.ac.uk
December 11, 2024 at 4:51 AM
You or someone you know interested in cell envelopes and getting a PhD? Come join me warwick.ac.uk/fac/cross_fa... or have a look at some of the other fantastic projects on offer @uni-of-warwick.bsky.social
Reposted by Phill Stansfeld
An interesting tool that employs MD Simulations to explain lipid densities in cryo-EM maps.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
LipIDens: simulation assisted interpretation of lipid densities in cryo-EM structures of membrane pr...
Interpretation of lipid-like densities in cryo-EM structures of membrane proteins is challenging. Here authors present LipIDens, enabling molecular dynamics analysis of protein-lipid interactions.
www.nature.com
November 29, 2023 at 3:46 PM
An interesting tool that employs MD Simulations to explain lipid densities in cryo-EM maps.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
🚨Job Alert🚨
As part of our BBSRC sLoLa award, David Roper,
@seamusholden.bsky.social and I have three 5-year PDRA positions available. Each is individually tailored to our groups, but will be part of the larger interdisciplinary team; also including Stephen Cochrane's group at QUB:
t.co/alJ0re8BBh
As part of our BBSRC sLoLa award, David Roper,
@seamusholden.bsky.social and I have three 5-year PDRA positions available. Each is individually tailored to our groups, but will be part of the larger interdisciplinary team; also including Stephen Cochrane's group at QUB:
t.co/alJ0re8BBh
3 x Research Fellow positions available to work on collaborative project - Coventry
3 x Research Fellow positions available to work on collaborative project between the Roper, Holden & Stansfeld laboratories at the School of Life S...
t.co
October 13, 2023 at 7:51 AM
🚨Job Alert🚨
As part of our BBSRC sLoLa award, David Roper,
@seamusholden.bsky.social and I have three 5-year PDRA positions available. Each is individually tailored to our groups, but will be part of the larger interdisciplinary team; also including Stephen Cochrane's group at QUB:
t.co/alJ0re8BBh
As part of our BBSRC sLoLa award, David Roper,
@seamusholden.bsky.social and I have three 5-year PDRA positions available. Each is individually tailored to our groups, but will be part of the larger interdisciplinary team; also including Stephen Cochrane's group at QUB:
t.co/alJ0re8BBh