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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 10h

Be sure to read research in our latest issue describing how a C4′-methyl-guanosine-modified 2′,3′-cyclic GMP-AMP dinucleotide elicits a robust innate immune response in hSTING-R232H cells from Yifei Zhou, Chuanzheng Zhou & co. at Nankai University #orgchem

Find itbelow👇

C4′-Me-modified 2′,3′-cGAMP elicits a robust innate immune response in cells harboring the loss-of-function hSTING-R232H variant

The 2′,3′-cyclic GMP-AMP dinucleotide (2′,3′-cGAMP) is a potent endogenous agonist of the STING (stimulator of interferon genes), playing a critical role in innate immune activation and representing…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 1d

Don't miss this paper from Gabriel E. Rudebusch & co. at Eastern Michigan University reporting new anthracene-isatoic anhydride hybrids as chromophores with nucleophile dependent response in our latest issue #orgchem

Check it out in full here👇

Anthracene-isatoic anhydride hybrids for bioconjugation: chromophores with nucleophile dependent response

The use of activated esters to label nucleophilic sites in biomolecules is a well established platform in bioconjugate chemistry. Here, we report the synthesis of a pair of anthracene–isatoic…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 2d

Check out this review from Sarat Chatterjee & Chinmay Chowdhury at CSIR-IICB in our latest issue providing their perspectives on the recent advances in the metal-catalysed syntheses of carbolines #organicchemistry

Read the full article on our website🔽

Perspectives on metal-catalysed syntheses of carbolines (α/β/γ/δ): recent advances

Pyridine-fused indole derivatives, commonly known as carbolines, have emerged as fascinating and privileged heterocyclic scaffolds because of their immense applications in medicinal chemistry,…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 3d

Take a look in our latest issue at research on the transition metal-free stereospecific di-chalcogenations of substituted acetylenes by Chin-Fa Lee et al. #orgchem

📍National Chung Hsing University

Transition metal-free stereospecific di-chalcogenations of substituted acetylenes

We report a one-pot, transition metal-free, stereospecific di-chalcogenation reaction for the synthesis of a diverse range of substituted Z-di-organochalcogenides. This method employs Cs2CO3 as a…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 4d

Be sure to read this paper from Christian Marcus Pedersen & co. at the University of Copenhagen reporting UV-mediated anomeric activation in our latest issue #organicchemistry

Find their full report below👇

UV-mediated anomeric activation

We report the UV-mediated activation of various glycosyl α-trichloroacetimidates (TCAs) to form glycosyl α-chlorides or O-glycosides depending on the carbohydrate, protecting groups, and solvent. In…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 5d

Don't miss this review in our latest issue from Meijuan Zhou, Xiaolong Yu et al. at Shandong University discussing the recent advances in iron-catalyzed 1,2-difunctionalization of alkenes #organicchemistry

Check it out in full here🔽

Recent advances in iron-catalyzed 1,2-difunctionalization of alkenes

Iron catalysts overcome the difficulties in the oxidative addition of halogenated hydrocarbons through the strategy of alkene insertion to form iron–carbon species and altering the reaction pathway…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 6d

📢Our latest issue is now online!

Check out the research behind the front cover by Tae Kyung Ko & Hyung Min Chi from POSTECH reporting the HFIP mediated transition metal-free synthesis of C4-aryl-substituted quinolines #orgchem

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 6d

📢We are delighted to announce a #OpenCall for papers to the RSC cross-journal themed collection Celebrating 200 Years of Benzene, guest edited by Ben Feringa @feringalab.bsky.social & Nazario Martin!

Find out more about the collection and how to submit here🔽
www.rsc.org/publishing/j...

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Reposted by Organic & Biomolecular Chemistry

Chemical Science @chemicalscience.rsc.org · 7d

New articles have been added to our 6th ERC Grantees Conference 2025 themed collection - read them here!

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This cross-journal collection showcases work from the speakers and delegates from this year’s 6th ERC Grantees Conference (Porvoo, Finland, 10-12 June 2025).

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 7d

🔓Be sure to read #OpenAccess research from Katarzyna Jastrzębska et al. at the Polish Academy of Sciences applying oxathiaphospholane chemistry for the synthesis of morpholino-based phosphorothioate analogs #orgchem

Find their full report below🔽

Morpholino-based phosphorothioate analogs via oxathiaphospholane chemistry: synthesis, structural insights and stability

We present the application of the oxathiaphospholane method for the synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs, showcasing its potential for creating…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 8d

🔓Don't miss in our latest issue a #OpenAccess review covering enantioselective Mukaiyama–Michael reactions and their application in total synthesis by Mukund P. Sibi & co. from @ndsuofficial.bsky.social #orgchem

Check out the full article here👇

Mukaiyama–Michael reaction: enantioselective strategies and applications in total synthesis

The Mukaiyama–Michael (M–M) reaction is a powerful approach for carbon–carbon bond formation and can provide access to all-carbon quaternary centers and vicinal stereocenters. The use of chiral…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 9d

🔓Check out #OpenAccess research from Parthasarathy Gandeepan et al. at IIT Tirupati describing the eco-efficient C–H alkynylation of indoles via mechanochemical ruthenium catalysis in our latest issue #organicchemistry

Read in full on our website🔽

Eco-efficient C–H alkynylation of indoles via mechanochemical ruthenium catalysis

A regioselective C2-alkynylation of indoles via ruthenium(ii)-catalyzed C–H activation using bromoalkynes is demonstrated under both solution-phase and mechanochemical conditions. The…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 10d

Take a look in our latest issue at this review looking at the recent advances in photoinduced amidyl radical-mediated remote C(sp3)–H activation via 1,5-hydrogen atom transfer by Meiling Ye, Chunjuan Liu & co. #organicchemistry

📍Sichuan University

Recent advances in photoinduced amidyl radical-mediated remote C(sp3)–H activation via 1,5-hydrogen atom transfer

C–H bonds are widely present in organic molecules and play a crucial role in chemical diversification. Among them, the functionalization of unactivated C(sp3)–H bonds is highly challenging. The…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 11d

🔓Be sure to read this #OpenAccess paper from Karl Hemming et al. @huddersfielduni.bsky.social in our latest issue on the synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones #organicchemistry

Find their full report below👇

The synthesis of β-enamino esters from the thermal, catalyst-free ring opening of aminocyclopropenones

In an attempt to react aminocyclopropenones with cyclic imines in order to synthesise amido-substituted pyrrolizidine natural products, we found that aminocyclopropenones undergo a previously…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 12d

Don't miss this paper in our latest issue by Cristian J. Guerra & co. from Universidad Andres Bello describing a computational exploration of the photochemical conversion of BN-Dewar benzene into BN-benzvalene #organicchemistry

Check it out in full here🔽

From BN-Dewar benzene to BN-benzvalene: a computational exploration of photoisomerization mechanisms

This study explores the photochemical conversion of BN-Dewar benzene into BN-benzvalene derivatives, offering a strategic route to heteroatom-containing valence isomers with distinctive electronic…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 13d

📢Our latest issue is now online!

🔓Check out the #OpenAccess review behind the front cover by Alessia Cavallaro, Giuseppe Trusso Sfrazzetto & co. from the University of Catania discussing formaldehyde sensing by fluorescent organic sensors #organicchemistry

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 13d

Take a look at this review in our latest issue from De-Xian Wang & co. looking at selective anion recognition by covalent organic cages #organicchemistry

📍Institute of Chemistry CAS

Selective anion recognition by covalent organic cages

Recent studies on selective anion recognition employing covalent organic cage hosts are reviewed. Cage-like host molecules with convergent anion binding sites (positively charged or neutral…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 14d

🔓Be sure to read #OpenAccess research by Eoghan M. McGarrigle et al. from @ucddublin.bsky.social describing the photochemical carbosulfonylative cross-coupling of alkenes #orgchem

Find their full report on our website👇

Photochemical carbosulfonylative cross-coupling of alkenes

A photochemical carbosulfonylative protocol for the formation of C–S and C–C bonds between sulfinate salts and alkenes is reported. This approach couples two alkene molecules to give access to highly…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 15d

🔓Don't miss this #OpenAccess review in our latest issue by Damien Hazelard, @compaingroup.bsky.social & co. @unistra.fr covering the recent advances in the construction of quaternary pseudoanomeric centers in gem-C,C-glycosides #organicchemistry

Check it out here🔽

Recent advances in the construction of quaternary pseudoanomeric centers in gem-C,C-glycosides: from zaragozic acids to remdesivir

Gem-C,C-glycosides—C-glycosides characterized by two carbon substituents at the pseudo-anomeric position—constitute a structurally distinctive class of glycomimetics with growing relevance in natural…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 16d

Be sure to read this paper describing azophotoswitches containing thiazole, isothiazole, thiadiazole, and isothiadiazole in our Photoswitches & Photopharmacology collection by Nobuyuki Tamaoki & co. from Hokkaido University #orgchem

Find their full report below👇

Azophotoswitches containing thiazole, isothiazole, thiadiazole, and isothiadiazole

We report a novel class of azophotoswitches incorporating various five-membered heteroaryl units such as thiazole, isothiazole, thiadiazole, and isothiadiazole. These azophotoswitches were developed…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 17d

Don't miss research in our Photoswitches & Photopharmacology collection from Subhabrata Maiti, Sugumar Venkataramani et al. at IISER Mohali reporting an azothiazole probe as a multianalyte colorimetric chemosensor for urea and biologically significant amines #orgchem

An azothiazole probe as a multianalyte colorimetric chemosensor for urea and biologically significant amines

We report an azothiazole-based probe as a chemosensor for urea with a LOD of 45 μM. The underlying sensing principle is an instantaneous color change associated with the complex forming between the…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 18d

🔓Check out this #OpenAccess paper by Conrad Averdunk & Hermann Wegner @wegnerlabs.bsky.social @jlugiessen.bsky.social in our Photoswitches & Photopharmacology collection investigating the structure–property relationship of substituted p-alkoxy-azothiophenes #orgchem

Read in full on our website🔽

Systematic investigation of the structure–property relationship of substituted p-alkoxy-azothiophenes

Differently substituted p-alkoxy azothiophenes with increasing alkoxy chains were systematically investigated in terms of their structure–property relationships. In particular, it was observed that…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 19d

🔓Take a look in our Photoswitches & Photopharmacology collection at a #OpenAccess paper from Kimio Sumaru, Kingo Uchida & co. on using a diarylethene photoswitch for photo-controllable cytotoxicity in cell culture #orgchem

📍AIST, Ryukoku University

Photo-controllable cytotoxicity in cell culture using a diarylethene photoswitch

For diarylethene (DAE) derivatives, whose dark cytotoxicity varies greatly depending on their isomerization state, we observe that the non-toxic open-ring isomer taken up by cells is converted to a…

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Organic & Biomolecular Chemistry @orgbiomolchem.rsc.org · 20d

📢Our latest issue is now online!

Check out the paper behind the front cover by Carl Jacky Saint-Louis & co. @kennesawstate.bsky.social reporting a pro-fluorescent ethynylthiophene-based o-nitrobenzyl photolabile protecting group for hydroxamic acid synthesis

pubs.rsc.org/en/content/a...

Reposted by Organic & Biomolecular Chemistry

Jim White @jimwhite-rsc.bsky.social · 20d

Join us next Thursday, October 2 for our next Desktop Seminar! This webinar will celebrate 200 years since the discovery of benzene and will feature talks on aromaticity from Renana Gershoni-Poranne (Technion) and Dean Tantillo (UC Davis).

Learn more and register here: rsc.zoom.us/webinar/regi...

RSC Desktop Seminar on 200 Years of Benzene: New Explorations of Aromaticity, taking place Thursday 2 October 2025 at 11 AM EDT / 4 PM BST

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