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Olli Kärkkäinen @ollikarkkainen.bsky.social · 2d

Interesting new paper on using multi-omics data-analysis methods in integrative holo-omics data-analysis. We were happy to contribute to the metabolomics part.

Congrats @jennymerkesvik.bsky.social‬ for the excellent work!

Jenny Merkesvik @jennymerkesvik.bsky.social · 3d

Check out this preprint of the first article for my PhD thesis!
www.biorxiv.org/content/10.1...

We've leveraged methods developed for multi-omics to investigate a holo-omic system (🐷🦠), and predicted host-microbiome interactions between important features for observed cross-omic data patterns 🔍📊

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Reposted by Olli Kärkkäinen

Aleksi Hamina @aleksihamina.bsky.social · Jul 5

Interesting new analysis of ADHD meds in schizophrenia-spectrum disorders: reduced risk of psychosis with atomoxetine and reduced risk for somatic hospitalizations with lisdexamphetamine.

Higher somatic hospitalization with polytherapy, no other negative safety signals. #psychiatry #medsky

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Reposted by Olli Kärkkäinen

Olli Kärkkäinen @ollikarkkainen.bsky.social · Jul 4

New publication!

Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...

#ADHD #schizophrenia

Long term safety of ADHD medication in patients with schizophrenia spectrum disorders - Molecular Psychiatry

Molecular Psychiatry - Long term safety of ADHD medication in patients with schizophrenia spectrum disorders

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jul 4

New publication!

Luykx et al. Long term safety of ADHD medication in patients with schizophrenia spectrum disorders. doi.org/10.1038/s413...

#ADHD #schizophrenia

Long term safety of ADHD medication in patients with schizophrenia spectrum disorders - Molecular Psychiatry

Molecular Psychiatry - Long term safety of ADHD medication in patients with schizophrenia spectrum disorders

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 25

We were able to get good metabolite profiles from microscopically small chicken gut samples. And show metabolite profile effects of Salmonella infection in different parts of the gut (central lumen, mucosal lumen or host tissue) and that synbiotic treatment can alleviate some of these changes.

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 25

Today in the #MetSoc2025 conference, I was presenting a poster about the microsample global metabolomics method development we have been doing in the 3D'omics project at Afekta Technologies !

Happy Olli presenting a poster in the Metabolomics 2025 conference

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Reposted by Olli Kärkkäinen

EMN Metabolomics Society @emn-metsoc.bsky.social · Jun 21

Heading to #Metabolomics2025? Here are some quick tips:
✅ Prague Congress Centre is easy to reach by public transport
✅ It can get warm – pack a water bottle
✅ Conference essentials: poster, laptop, and charger
✅ Check out the full agenda here: tinyurl.com/4vudznw8
#Prague2025 #EMN #ConferenceTips

Agenda - Metabolomics 2025

www.metabolomics2025.org

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Reposted by Olli Kärkkäinen

Chris Pook @drchrispook.bsky.social · Jun 21

To everyone heading to #Metabolomics2025 in Prague, I recommend installing the Prague public transport app. It's extremely helpful!
play.google.com/store/apps/d...

PID Litacka - Apps on Google Play

Official transport application of Prague integrated transport system (PID)

play.google.com

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Reposted by Olli Kärkkäinen

Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 20

Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!

Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....

...

Metabolic Alterations in Human Post‐Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine

A metabolic profile associated with high levels of the nicotine metabolite cotinine was measured from human postmortem frontal cortex and cerebrospinal fluid samples using non-targeted metabolomics. ....

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 20

Thank you!

For the human post-mortem study, unfortunately the ethical approval does not allow for public sharing of the data.

For the pig heart study, there is a plan for public release of the metabolomics data of also other analysed organs in the near future.

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 20

And of course we also celebrated the Midsummer!

Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 20

... And a first first author paper for talented doctoral researcher Reta Haikonen: Blueprint of the distinct metabolite profiles of healthy pig heart chambers:
doi.org/10.1016/j.jm...

Redirecting

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 20

Just in time for Midsummer festives and next weeks Metabolomics conference, two new articles were published!

Masvosva et al. Metabolic Alterations in Human Post-Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine: doi.org/10.1111/adb....

...

Metabolic Alterations in Human Post‐Mortem Frontal Cortex and Cerebrospinal Fluid Associated With High Levels of Nicotine Metabolite Cotinine

A metabolic profile associated with high levels of the nicotine metabolite cotinine was measured from human postmortem frontal cortex and cerebrospinal fluid samples using non-targeted metabolomics. ....

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 16

This is the first first author manuscript for the excellent doctoral researcher Dennisse Avella! This study was part of the @human-dn.bsky.social with great co-authors: Soile Turunen, Glykeria Avgerinou, Anatoli Petridou, Vassilis Mougios, Iman Zarei, Seppo Auriola and Kati Hanhineva

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Olli Kärkkäinen @ollikarkkainen.bsky.social · Jun 16

New preprint alert! 🚨

We compared metabolite coverage of three blood microsampling devices as an alternative to conventional samples for human biomonitoring. All devices were suitable for #metabolomics analysis and the choice of device depends on the application

chemrxiv.org/engage/chemr...

An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma.

Introduction: Blood microsampling (BµS) devices collect less than 100 µL of blood, offering a less invasive and more cost-effective alternative to venipuncture. However, its metabolomic comparability ...

chemrxiv.org

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Reposted by Olli Kärkkäinen

Pieter Dorrestein @pieterdorrestein.bsky.social · Jun 12

If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...

The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids

Mass spectrometry data mining tools enabled the creation of an MS/MS spectral library containing hundreds of N-acyl lipids, including conjugates with short-chain fatty acids. This resource enabled the...

www.cell.com

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Reposted by Olli Kärkkäinen

Olli Kärkkäinen @ollikarkkainen.bsky.social · May 19

New preprint! 🚨

Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies

doi.org/10.1101/2025...

Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies

Introduction Antenatal depression, a common pregnancy complication, poses significant risks if untreated. Consequently, pregnant mothers are prescribed selective serotonin reuptake inhibitors (SSRIs)....

doi.org

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Olli Kärkkäinen @ollikarkkainen.bsky.social · May 19

New preprint! 🚨

Itkonen et al. Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies

doi.org/10.1101/2025...

Metabolomic Insights: LC-MS Profiling of Human Placental Tissue from SSRI-Treated Pregnancies

Introduction Antenatal depression, a common pregnancy complication, poses significant risks if untreated. Consequently, pregnant mothers are prescribed selective serotonin reuptake inhibitors (SSRIs)....

doi.org

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Reposted by Olli Kärkkäinen

Juuso Koponen @juusokoponen.bsky.social · May 19

HS:n eilisessä velka-artikkelissa sivuutettiin lähes kokonaan valtionvelan hoitokustanukset ja inflaatio. Vaikka valtionvelan määrä on kasvanut, se kuormittaa julkista taloutta 2000-luvun alkua vähemmän, koska Suomi saa lainaa paljon aiempaa halvemmalla ja inflaatio pienentää lainapääoman arvoa. 1/

Tilastokuvio, joka on otsikoitu: ”Vaikka valtionvelka on kasvanut vuodesta 2008 alkaen, velan hoidon reaalinen (inflaation huomioiva) kustannus on laskenut. Vuosina 2021–2024 inflaatio pienensi velan pääoman arvoa enemmän kuin lainasta maksettiin korkoa.” Kuviossa on kaksi sarjaa pylväitä. Punaiset pylväät kuvaavat valtionvelan efektiivisiä hoitokuluja vuoden 2024 rahassa. Nämä kustannukset laskivat 2002–2021 yli 7 miljardista noin 500 miljoonaan vuodessa. Vuosina 2023–2024 kustannukset ovat jälleen nousseet n. 2 miljardiin. Siniset pylväät kuvaavat inflaation vaikutusta velan reaaliarvoon. Aikavälillä 2002–2020 inflaatio pysytteli enimmäkseen melko maltillisella tasolla ja useimpina vuosina inflaatio pienensi velan arvoa vain noin miljardilla vuodessa tai vähemmän. Vuosina 2021–2024 inflaatio on kuitenkin ollut voimakkaampaa ja sen vaikutus velan arvoon on ollut n. 3–10 miljardia vuodessa. Pylväiden lisäksi kuviossa on näiden kahden sarjan erotusta kuvaava viiva, joka on nimetty ”reaaliset lainanhoitokulut”. Se laski vuoteen 2020 suunnilleen samaa tahtia lainanhoidon efektiivisen kustannuksen kanssa, mutta vuosina 2021–2024 voimakas inflaatio on kääntänyt sarjan selvästi miinukselle, niin että 2022–2023 reaaliset lainanhoitokulut olivat noin 8 miljardia miinuksella. Vuonna 2024 erotus palautui lähelle nollaa, pysyen kuitenkin lievästi miinuksella.

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Reposted by Olli Kärkkäinen

Leah Mayo @mayoonthebrain.bsky.social · May 17

Its a long weekend here in Canada, which seems appropriate to mourn our recent @npp-journal.bsky.social paper, in which we find that FAAH inhibition does NOT improve symptoms in PTSD🙁

A heroic effort w/ @cannabrain.bsky.social @connorhaggarty.bsky.social @ryanntansey.bsky.social & many more 🧵⬇️

The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of post-traumatic stress disorde...

Neuropsychopharmacology - The efficacy of elevating anandamide via inhibition of fatty acid amide hydrolase (FAAH) combined with internet-delivered cognitive behavioral therapy in the treatment of...

www.nature.com

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Reposted by Olli Kärkkäinen

medRxivpreprint @medrxivpreprint.bsky.social · May 13

METABOLOMIC INSIGHTS: LC-MS PROFILING OF HUMAN PLACENTAL TISSUE FROM SSRI-TREATED PREGNANCIES https://www.medrxiv.org/content/10.1101/2025.05.12.25327429v1

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Olli Kärkkäinen @ollikarkkainen.bsky.social · May 14

First first author article for Eemeli Puhakka published!

We identified a profile of metabolites separating those with early stage progressive alcohol-related liver disease from non-progressive alcohol-related liver disease using metabolomics

doi.org/10.1111/liv....

#metabolomics #alcohol

Serum Metabolite Profile in Progressive Versus Nonprogressive Alcohol‐Related Liver Disease: A Cross‐Sectional Metabolomics Study

Background and Aims Alcohol-related liver disease (ALD) is a major cause of mortality and disability-adjusted life years. It is not fully understood why a small proportion of patients develop progre...

doi.org

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Reposted by Olli Kärkkäinen

James MacRae @jamesmacraedonkey.bsky.social · May 7

🚨 📢 I’m #hiring!!! I am looking for an experienced #metabolomics scientist with a particular focus on LC-MS. Please follow the link below for more details and how to apply! 📢 🚨
Applications close at 23:59 on May 23rd!!!

www.crick.ac.uk/careers-stud...

Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist

www.crick.ac.uk

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Olli Kärkkäinen @ollikarkkainen.bsky.social · May 5

New publication from the Gut2Behave project!

Neyrinck, Ahmed et al. Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health.

doi.org/10.1038/s415...

#metabolomics

Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health - Scientific Reports

Scientific Reports - Fecal transplantation from humans with obesity to mice drives a selective microbial signature without impacting behavioral and metabolic health

doi.org

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Reposted by Olli Kärkkäinen

The Metabolomics Society @metsoc.bsky.social · Apr 22

Important update! Thinking of submitting a poster abstract? Do not delay. Due to the high (and exciting!) volume of abstracts we will likely close abstract submission BEFORE May 15. Submit your abstract ASAP!

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