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Reposted by Nic Lehrbach

PLOS Biology @plosbiology.org · May 27

#Celegans peel-1/zeel-1 is one of the best-characterized animal #toxin-antidote systems, but how does it work? @lewsiferase.bsky.social &co show that PEEL-1 co-opts the PMPL-1 to exert toxicity by creating a novel #IonChannel that leads to cell swelling @plosbiology.org 🧪 plos.io/3HfH8LN

Selected frames of a live-cell imaging time-course experiment. A single cell is shown, co-expressing PEEL-1::eGFP and PMPL-1::mCherry. The nucleus is labeled (“N”). t = 0 is 16 hrs after transfection. Acute swelling can be seen (t = 2 hr 30 min), followed by a transient blob or protrusion (arrow) jetted out by the cell (t = 4 hr 15 min) and later reabsorbed (dotted arrow) (t = 4 hr 20 min). Scale bar = 10 µm.

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Reposted by Nic Lehrbach

Lucas Sullivan @lucasbsullivan.bsky.social · Feb 20

Excited to share a recent preprint by Oliver Newsom, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside:

A broadly applicable serum-free media,
Quantitative lipid uptake characterization,
Evidence lipid scavenging > synthesis for cancer cell proliferation.

bioRxivpreprint @biorxivpreprint.bsky.social · Feb 17

Defined media reveals the essential role of lipid scavenging to support cancer cell proliferation https://www.biorxiv.org/content/10.1101/2025.02.12.637975v1

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Reposted by Nic Lehrbach

Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Feb 15

Huge congratulations @jbloomlab.bsky.social!

Fred Hutch @fredhutch.org · Feb 14

Congrats to Fred Hutch evolutionary biologist
@jbloomlab.bsky.social on being named a fellow of the American Academy of Microbiology, an honorific leadership group within the American Society for Microbiology! Read more: bit.ly/3EFmnb1 @hutchbasicsci.bsky.social

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Reposted by Nic Lehrbach

Irini Topalidou @irinakitop.bsky.social · Feb 9

In the midst of the dark ages, we MUST retain optimism—keep going, keep publishing, keep talking science, and keep doing fun experiments! Our latest paper on the fascinating TF SKN-1/NRF presents exciting new findings using our one and only #Celegans #genetics #oxidativestress #proteasome

Nic Lehrbach @nlehrbach.bsky.social · Feb 7

Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).

www.biorxiv.org/content/10.1...

Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2

The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregu...

www.biorxiv.org

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Nic Lehrbach @nlehrbach.bsky.social · Feb 7

Our latest work on the ever-fascinating skn-1 transcription factor (Nrf1 and Nrf2 for non-worm people).

www.biorxiv.org/content/10.1...

Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2

The Nrf/NFE2L family of transcription factors regulates redox balance, xenobiotic detoxification, metabolism, proteostasis, and aging. Nrf1/NFE2L1 is primarily responsible for stress-responsive upregu...

www.biorxiv.org

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Reposted by Nic Lehrbach

Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Jan 24

Check out a fantastic @elife.bsky.social article highlighting @yarimura.bsky.social’s MagIC #cryoEM technique - a method using specialized magnetic beads that makes it possible to study the structure of proteins from dilute samples. elifesciences.org/articles/105...

Cryogenic Electron Microscopy: MagIC beads for scarce macromolecules

Specialized magnetic beads that bind target proteins to a cryogenic electron microscopy grid make it possible to study the structure of protein complexes from dilute samples.

elifesciences.org

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Reposted by Nic Lehrbach

Fred Hutch Basic Sciences Division @hutchbasicsci.bsky.social · Nov 22

The best part of the week kicks off soon: Friday Afternoon Seminars!

Can’t wait to learn about the latest research from Elyse Christensen in the @nlehrbach.bsky.social Lab and Liberalis Boila in Human Biology’s Kugel Lab. For all our @FredHutch.bsky.social colleagues, join us for two great talks!

Friday Afternoon Seminars (FAS), this Friday 11/22 at 4pm in Pelton.

Elyse Christensen, Lehrbach Lab
A cabal of conserved ubiquitin ligases cooperate to ensure robust protein turnover

Liberalis Boila, Kugel Lab
Epigenetic dysregulation in IDH mutant intrahepatic cholangiocarcinoma

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