Nixa Sedes, MD
@nixassedes.bsky.social
MD Internal Medicine Specialist Avid reader Science and Technology Philosophy History Astronomy Archaeology and Paleontology lover Proud mother of one
Microphysiological systems to advance human pathophysiology and translational medicine🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Microphysiological systems to advance human pathophysiology and translational medicine
Microphysiological systems (MPS) or “organ-on-a-chip” models are sophisticated tools that harness techniques from cell biology, tissue engineering, and microengineering to recapitulate human physiology. Typically, MPS are biofabricated ...
pmc.ncbi.nlm.nih.gov
November 29, 2025 at 5:35 PM
Microphysiological systems to advance human pathophysiology and translational medicine🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Gut Hormones in Heart Failure🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Gut Hormones in Heart Failure | Circulation: Heart Failure
Heart failure (HF) is a syndrome affecting all organ systems. While some organ interactions
have been studied intensively in HF (such as the cardiorenal interaction), the endocrine
gut has to some deg...
www.ahajournals.org
November 29, 2025 at 5:22 PM
Gut Hormones in Heart Failure🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
A human isolate of bovine H5N1 is transmissible and lethal in animal models🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
A human isolate of bovine H5N1 is transmissible and lethal in animal models
The outbreak of clade 2.3.4.4b highly pathogenic avian influenza viruses of the H5N1 subtype (HPAI H5N1) in dairy cows in the US has so far resulted in spillover infections of at least thirteen farm workers1–3, who presented with mild respiratory ...
pmc.ncbi.nlm.nih.gov
November 29, 2025 at 5:19 PM
A human isolate of bovine H5N1 is transmissible and lethal in animal models🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reaching new heights in genetic code manipulation with high throughput screening🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reaching new heights in genetic code manipulation with high throughput screening
The chemical and physical properties of proteins are limited by the twenty canonical amino acids, but genetic code manipulation allows for the incorporation of noncanonical amino acids (ncAAs), enhancing protein functionality. This review explores ...
pmc.ncbi.nlm.nih.gov
November 29, 2025 at 5:16 PM
Reaching new heights in genetic code manipulation with high throughput screening🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...
pmc.ncbi.nlm.nih.gov/articles/PMC...
Reposted by Nixa Sedes, MD
People with #MASLD can progress to cirrhosis & hepatocellular carcinoma & are at increased risk of developing type 2 diabetes, cardiovascular disease, chronic kidney disease, & extrahepatic cancers. Most people with MASLD die from cardiac-related causes www.thelancet.com/journals/lan...
#OpenAccess
#OpenAccess
November 29, 2025 at 5:02 PM
People with #MASLD can progress to cirrhosis & hepatocellular carcinoma & are at increased risk of developing type 2 diabetes, cardiovascular disease, chronic kidney disease, & extrahepatic cancers. Most people with MASLD die from cardiac-related causes www.thelancet.com/journals/lan...
#OpenAccess
#OpenAccess
Text-to-music generation models capture musical semantic representations in the human brain🔓
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Text-to-music generation models capture musical semantic representations in the human brain - Nature Communications
How the brain represents high-level musical meaning is unclear. Here, the authors reconstruct heard music from fMRI data and show that both music- and text-derived semantic features are predictive of ...
www.nature.com
November 29, 2025 at 11:47 AM
Text-to-music generation models capture musical semantic representations in the human brain🔓
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Nixa Sedes, MD
GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer. Read more in #JES: bit.ly/4acTEYP #alcoholusedisorder #addiction #GLP-1 @endocrinesociety.bsky.social
GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer
Abstract. Alcohol and other substance use disorders (ASUDs) are complex, multifaceted, but treatable medical conditions with widespread medical, psychologi
bit.ly
November 28, 2025 at 11:13 PM
GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer. Read more in #JES: bit.ly/4acTEYP #alcoholusedisorder #addiction #GLP-1 @endocrinesociety.bsky.social
Engineering Biomimetic Lung-on-a-Chip Systems: Recapitulating Air-Liquid Interface, Dynamic Breathing, and Alveolar Microenvironments for Disease Modeling🔓
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Engineering Biomimetic Lung-on-a-Chip Systems: Recapitulating Air-Liquid Interface, Dynamic Breathing, and Alveolar Microenvironments for Disease Modeling
The lung is a vital organ for gas exchange. Its microstructure is complex and changes in its physiology are crucial to human health. Lung disease is o…
www.sciencedirect.com
November 28, 2025 at 4:27 PM
Engineering Biomimetic Lung-on-a-Chip Systems: Recapitulating Air-Liquid Interface, Dynamic Breathing, and Alveolar Microenvironments for Disease Modeling🔓
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Plastics from Surface to Seabed: Vertical Distribution of (Micro)plastic Particles in the North Pacific Ocean🔓 | Environmental Science & Technology pubs.acs.org/doi/10.1021/...
Plastics from Surface to Seabed: Vertical Distribution of (Micro)plastic Particles in the North Pacific Ocean
In this study, the vertical distribution of microplastic items across the water column and deep-sea sediments in the North Pacific Ocean, at depths exceeding 5 km, was investigated, covering two previ...
pubs.acs.org
November 28, 2025 at 4:14 PM
Plastics from Surface to Seabed: Vertical Distribution of (Micro)plastic Particles in the North Pacific Ocean🔓 | Environmental Science & Technology pubs.acs.org/doi/10.1021/...
Scientists develop plastics that can break down, tackling pollution | EurekAlert! www.eurekalert.org/news-release...
Scientists develop plastics that can break down, tackling pollution
In a study published in Nature Chemistry, Rutgers chemist Yuwei Gu and a team of Rutgers scientists have shown that by borrowing a principle from nature, they can create plastics that break down under...
www.eurekalert.org
November 28, 2025 at 11:14 AM
Scientists develop plastics that can break down, tackling pollution | EurekAlert! www.eurekalert.org/news-release...
Applications of Raman spectroscopy for microplastic detection and characterization: a comprehensive spectral reference🔓
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Applications of Raman spectroscopy for microplastic detection and characterization: a comprehensive spectral reference - Environmental Science and Pollution Research
Microplastics (MPs), plastic particles smaller than 5 mm, represent an escalating global concern due to their persistence, ubiquity, and potential risks to ecosystems and human health. This review cri...
link.springer.com
November 28, 2025 at 11:07 AM
Applications of Raman spectroscopy for microplastic detection and characterization: a comprehensive spectral reference🔓
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Nixa Sedes, MD
A paper in Nature presents evidence of lightning on Mars, detected in sounds and electrical signals captured by NASA’s Perseverance rove. The observations indicate that Mars’s atmosphere is electrically active, which may have implications for future exploration. go.nature.com/49IbPpg 🔭 🧪
November 27, 2025 at 2:12 PM
A paper in Nature presents evidence of lightning on Mars, detected in sounds and electrical signals captured by NASA’s Perseverance rove. The observations indicate that Mars’s atmosphere is electrically active, which may have implications for future exploration. go.nature.com/49IbPpg 🔭 🧪
Reposted by Nixa Sedes, MD
The elevated risk of blood clots in women with obesity using estrogen-based contraceptives has—until now—been an unresolved clinical observation
Rinku Majumder & team now show estrogen & obesity synergistically suppress the anticoagulant PS via HIF-1alpha: www.jci.org/articles/vie...
Rinku Majumder & team now show estrogen & obesity synergistically suppress the anticoagulant PS via HIF-1alpha: www.jci.org/articles/vie...
November 27, 2025 at 5:15 PM
The elevated risk of blood clots in women with obesity using estrogen-based contraceptives has—until now—been an unresolved clinical observation
Rinku Majumder & team now show estrogen & obesity synergistically suppress the anticoagulant PS via HIF-1alpha: www.jci.org/articles/vie...
Rinku Majumder & team now show estrogen & obesity synergistically suppress the anticoagulant PS via HIF-1alpha: www.jci.org/articles/vie...
River drought forcing of the Harappan metamorphosis
www.nature.com/articles/s43...
www.nature.com/articles/s43...
River drought forcing of the Harappan metamorphosis - Communications Earth & Environment
Hydroclimatic variations significantly influenced the Indus Valley Civilization's rise and fall, with warmer, drier conditions during pre-Harappan to late-Harappan periods leading to human migration a...
www.nature.com
November 27, 2025 at 5:12 PM
River drought forcing of the Harappan metamorphosis
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Reposted by Nixa Sedes, MD
KICS is a distinct condition that is commonly associated with KS and requires exclusion of other KAD, such as MCD and PEL. Rituximab with KS treatment may be beneficial in selected patients with KICS, but this diagnosis is associated with high mortality. Read in BA: buff.ly/wFRCJWe
November 27, 2025 at 1:44 PM
KICS is a distinct condition that is commonly associated with KS and requires exclusion of other KAD, such as MCD and PEL. Rituximab with KS treatment may be beneficial in selected patients with KICS, but this diagnosis is associated with high mortality. Read in BA: buff.ly/wFRCJWe
Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis🔓 | PNAS www.pnas.org/doi/abs/10.1...
Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis | PNAS
The activation of blood monocytes and the infiltration of monocyte-derived macrophages
into the vessel walls are the central part of atherosclerosi...
www.pnas.org
November 27, 2025 at 1:45 PM
Myeloid GPSM1 regulates atherosclerosis progression by governing monocyte and macrophage activation and chemotaxis🔓 | PNAS www.pnas.org/doi/abs/10.1...
Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights🔓 - Daneshgar - Advanced NanoBiomed Research - Wiley Online Library
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights
This review explores how surface-coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications,...
advanced.onlinelibrary.wiley.com
November 27, 2025 at 11:58 AM
Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights🔓 - Daneshgar - Advanced NanoBiomed Research - Wiley Online Library
advanced.onlinelibrary.wiley.com/doi/10.1002/...
advanced.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Nixa Sedes, MD
The publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"!
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Engineering complexity into protein-based biomaterials for biomedical applications - Nature Reviews Materials
Protein-based biomaterials are becoming increasingly prevalent in biomedical applications that treat and prevent disease. This Perspective examines the evolution of techniques used to build and design...
doi.org
November 26, 2025 at 10:58 PM
The publishing streak continues! Excited to share our new article in Nature Reviews Materials (@natrevmats.nature.com) entitled "Engineering Complexity into Protein-based Biomaterials for Biomedical Applications"!
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
Check it out here:
📜: doi.org/10.1038/s415...
🔓: rdcu.be/eRFDh
“Homo informatio”🔓
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
“Homo informatio”
A phylogenetic split ∼7.5 Ma (million years ago) separated paninan ancestors that were unlike today's chimpanzees, from homininan ancestors that were …
www.sciencedirect.com
November 27, 2025 at 10:50 AM
“Homo informatio”🔓
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Unmasking the Hidden Burden: Inflammation and Cardiovascular Disease JAHA Spotlight on the Role of the Immune System in Cardiovascular Health and Disease🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Unmasking the Hidden Burden: Inflammation and Cardiovascular Disease JAHA Spotlight on the Role of the Immune System in Cardiovascular Health and Disease | Journal of the American Heart Association
www.ahajournals.org
November 27, 2025 at 10:36 AM
Unmasking the Hidden Burden: Inflammation and Cardiovascular Disease JAHA Spotlight on the Role of the Immune System in Cardiovascular Health and Disease🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Reposted by Nixa Sedes, MD
Dinosaurian extinction—asteroid impact or volcanic activity? New research in #GSABulletin concludes that volcanism and resulting environmental degradation was the primary cause.
Read the full article: geosociety.co/4r1VG41
#Volcanology #Chicxulub #ImpactCrater
Image: Figure 4 from the paper.
Read the full article: geosociety.co/4r1VG41
#Volcanology #Chicxulub #ImpactCrater
Image: Figure 4 from the paper.
November 26, 2025 at 10:00 PM
Dinosaurian extinction—asteroid impact or volcanic activity? New research in #GSABulletin concludes that volcanism and resulting environmental degradation was the primary cause.
Read the full article: geosociety.co/4r1VG41
#Volcanology #Chicxulub #ImpactCrater
Image: Figure 4 from the paper.
Read the full article: geosociety.co/4r1VG41
#Volcanology #Chicxulub #ImpactCrater
Image: Figure 4 from the paper.
Ancient DNA from Shimao city records kinship practices in Neolithic China🔓
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Ancient DNA from Shimao city records kinship practices in Neolithic China - Nature
Sequencing of 144 ancient genomes from Shimao city and its satellites presents pedigrees among tomb owners spanning up to four generations showing predominantly patrilineal descent structure across Sh...
www.nature.com
November 26, 2025 at 8:47 PM
Ancient DNA from Shimao city records kinship practices in Neolithic China🔓
www.nature.com/articles/s41...
www.nature.com/articles/s41...
OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development | Circulation
Background: Cardiovascular disease caused by atherosclerosis is responsible for 18
million deaths annually, highlighting a significant need for new medical therapies,
especially for patients who are n...
www.ahajournals.org
November 26, 2025 at 6:49 PM
OxLDL-Targeted Chimeric Antigen Receptor T Regulatory Cells Reduce Atherosclerotic Plaque Development🔓
www.ahajournals.org/doi/10.1161/...
www.ahajournals.org/doi/10.1161/...
Neuroanatomical convergence between pterosaurs and non-avian paravians in the evolution of flight 🔓 Current Biology www.cell.com/current-biol...
Neuroanatomical convergence between pterosaurs and non-avian paravians in the evolution of flight
Bronzati et al. show that pterosaurs, the first flying reptiles, evolved brains resembling
bird precursors but not modern birds. They also demonstrate that, unlike birds, which
built on inherited dino...
www.cell.com
November 26, 2025 at 6:39 PM
Neuroanatomical convergence between pterosaurs and non-avian paravians in the evolution of flight 🔓 Current Biology www.cell.com/current-biol...
Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough🔓 jamanetwork.com/journals/jam...
Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough
This cohort study examines the clinical association between glucagon-like peptide 1 receptor agonists and chronic cough.
jamanetwork.com
November 26, 2025 at 4:58 PM
Glucagon-Like Peptide-1 Receptor Agonists and Chronic Cough🔓 jamanetwork.com/journals/jam...