Spokane Raging GranniesFall Folk FestivalThe UndergroundSpokane Community CollegeSpokane, WASaturday, November 8, 2025, 1:45-2:15pmAudience Recording01. -...

What can mapped drainage systems on Mars teach scientists about the Red Planet’s watery past? This is what a recent study published in the Proceedings of the National Academy of Sciences hopes to address as a team of scientists from the University of Texas at Austin (UT Austin) conducted a first-time mapping study involving Martian river basins. This study has the potential to not only gain insight into ancient Mars and how much water existed there long ago but also develop new methods for mapping ancient river basins on Mars and potentially other worlds.

Photo: Herb Greene The Grateful Dead have claimed a new title. Today, 60 years after the band performed their first gig, a San Jose Acid Test, under the

Analyses of German medical manuals from 1531 reveal what ingredients those who handled the books used

The Kremlin pitched the White House on peace through business. To Europe’s dismay, the president and his envoy are on board.

DNA in foods is a source of nucleotides that are salvaged by tissues as building blocks for chromosomal and mitochondrial DNA. A recent study provided preliminary evidence that high-temperature cookin...

STING activates the innate immune system by inducing type-1 interferon (IFN) production and has been pursued as a therapeutic option in immuno-oncology. The targeted delivery of STING agonists to CCR2+ immune cells could enhance the therapeutic window of the agonists by selectively activating the STING pathway within targeted immune cells. The chemistry strategy was established to enable the targeted delivery of the cyclic dinucleotide STING agonist dazostinag to CCR2+ cells through an antibody-drug conjugate (ADC) approach. A self-immolative spacer between the adenine of dazostinag and the Cathepsin-B cleavable Val-Ala dipeptide linker rendered a linker payload that exhibits strong plasma stability while allowing the rapid payload release upon internalization into lysosomes. The stochastic cysteine conjugation of the dazostinag containing these linkers provided ADC TAK-500 and its mouse surrogate mTAK-500 with DAR = 4. In syngeneic tumor-bearing mouse models, mTAK-500 showed target specific antitumor activity as well as the induction of immune-stimulating cytokines.

STA is partnering with the Transit App to give local riders a chance to make public transportation less stressful with premium features like live GPS bus tracking.

Eastern Washington University has emerged as one of the nation’s cybersecurity education leaders, with hundreds of graduates working around the country to protect networks, devices and data.

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...