Lara Muffley
@muffley.bsky.social
Director of Program Operations (Variant Effects Portfolio) CMAP, CAVA and the Atlas of Variant Effects Alliance | she/her 🏳️🌈
https://fowlerlab.gs.washington.edu/people
https://brotmanbaty.org/research/atlas-of-variant-effects
https://fowlerlab.gs.washington.edu/people
https://brotmanbaty.org/research/atlas-of-variant-effects
Pinned
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
Happening now!
Zoom link here: www.varianteffect.org/seminar-seri...
Zoom link here: www.varianteffect.org/seminar-seri...
Update for today's seminar: Presentation with @taylor-mighell.bsky.social (postdoc w/ @benlehner.bsky.social) on "Understanding GPCRs with massive mutagenesis"
(Thea will present with us at a later date)
Find the Zoom link on our website: www.varianteffect.org/seminar-seri...
(Thea will present with us at a later date)
Find the Zoom link on our website: www.varianteffect.org/seminar-seri...
December 2, 2025 at 5:08 PM
Happening now!
Zoom link here: www.varianteffect.org/seminar-seri...
Zoom link here: www.varianteffect.org/seminar-seri...
Today is the deadline to submit your abstract.
Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
December 1, 2025 at 6:40 PM
Today is the deadline to submit your abstract.
Reposted by Lara Muffley
Did you know that we have a Variant Effects Seminar Series playlist on YouTube? Tune in to watch previously recorded talks at your leisure 📺☕ www.youtube.com/playlist?lis... #FunctionalGenomics #Seminar
December 1, 2025 at 3:15 PM
Did you know that we have a Variant Effects Seminar Series playlist on YouTube? Tune in to watch previously recorded talks at your leisure 📺☕ www.youtube.com/playlist?lis... #FunctionalGenomics #Seminar
Reposted by Lara Muffley
Tomorrow!
www.varianteffect.org/seminar-seri...
www.varianteffect.org/seminar-seri...
December 1, 2025 at 3:54 PM
Tomorrow!
www.varianteffect.org/seminar-seri...
www.varianteffect.org/seminar-seri...
Reposted by Lara Muffley
The FINAL Deadline to submit your #VariantEffect26
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...
MSS26 - Abstract submission
This form will enable you to submit an abstract for consideration for presentation at the 2026 Mutational Scanning Symposium & Workshop (MSS26). MSS26 will be held at the Aikenhead Centre for Medical ...
docs.google.com
November 27, 2025 at 1:39 PM
The FINAL Deadline to submit your #VariantEffect26
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...
#abstract is ⏰🗓️🔜 December 1st, 2025!
ℹ️ www.mss2026.org
📝 docs.google.com/forms/d/e/1F...
Reposted by Lara Muffley
Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
November 27, 2025 at 1:44 PM
Be sure to submit your abstract by December 1st! #VariantEffect26 #abstract #final #deadline
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
Please note that there will be no extensions ⌛
ℹ️ www.mss2026.org
Reposted by Lara Muffley
So looking forward to this meeting!
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:29 PM
So looking forward to this meeting!
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
November 25, 2025 at 7:17 PM
Also! We'd love your help in promoting this event in the #Australia #Australasia region! Topics and programming will be of interest to the #FunctionalGenomics #Genomics #Clinical #Research #Community ℹ️https://www.mss2026.org
#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
If you are planning to attend the Mutational Scanning Symposium (and companion workshops!) we recommend that you register as soon as possible to secure your spot!
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow
ℹ️ www.mss2026.org
Keynotes! @mehurles.bsky.social @maitreya.bsky.social
#VariantEffect26 #Symposium #Workshop #RegisterNow
November 24, 2025 at 3:12 PM
#VariantEffect26 will be in Melbourne Australia! 🐨
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
Note that there will be a computational modeling and a clinical variant interpretation workshop!!
Discounted tickets available for participants from LMICs.
More info and to register www.mss2026.org
Reposted by Lara Muffley
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
📝 Excited to share our latest work, now out at European Heart Journal! We studied 252 SCN5A variants previously found in patients with Brugada Syndrome, an inherited arrhythmia disorder linked to sudden cardiac death. [1/4]
November 21, 2025 at 12:14 AM
Thank you @amglazer.bsky.social for the exciting opportunity to collaborate! Since then, we've provided functional evidence supporting the VUS reclassification in children with abnormal sodium #ionchannel function at Sydney Children’s Hospital.
Reposted by Lara Muffley
🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
November 18, 2025 at 12:47 PM
🧬 #SponsorshipOpportunity #VariantEffect26
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
For more info reach out directly to @muffley.bsky.social
or inquire here 📧 www.mss2026.org
We'd love to have your support!
Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)
Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
November 10, 2025 at 2:30 PM
Join us for a special @varianteffect.bsky.social Fireside Chat on Jan 6th, 2026 (9-10am Pacific) w/ @maitreya.bsky.social (@uwgenome.bsky.social) & @mehurles.bsky.social (@sangerinstitute.bsky.social)
Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
Visit www.varianteffect.org/event/firesi...
for more info and to add this event to your calendar
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
November 4, 2025 at 6:48 PM
Looking for some heartwarming and interesting stories about early-career scientists making strides in genomics and precision medicine right here in Seattle? Check out the @brotmanbaty.bsky.social 's Promising Young Scientists Series! brotmanbaty.org/news/categor... @uwgenome.bsky.social
🦕🦖🦕🦖🦕🦖 Conference dinner at Melbourne Museum ! Yes please.
2026 Mutational Scanning Symposium & Workshop will be here before you know it! Register now to secure your spot and get a ticket 🎟️ for the conference dinner at Melbourne Museum! 🦕 tinyurl.com/MSS26Registr... #VariantEffect26 #Dinosaurs #RegisterNow
November 4, 2025 at 3:13 PM
🦕🦖🦕🦖🦕🦖 Conference dinner at Melbourne Museum ! Yes please.
Reposted by Lara Muffley
November 3, 2025 at 2:30 PM
Reposted by Lara Muffley
We have an incredible speaker line-up for next years Mutational Scanning Symposium 🤩. Register now and submit your abstract before the deadline next week!
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
October 31, 2025 at 2:11 PM
We have an incredible speaker line-up for next years Mutational Scanning Symposium 🤩. Register now and submit your abstract before the deadline next week!
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
ℹ️ www.mss2026.org
#VariantEffect26 #FOMO #Functional #Genomics #Symposium #Abstract #Deadline
Reposted by Lara Muffley
brotmanbaty.org/news/q-and-a... @brotmanbaty.bsky.social Q&A with #VariantEffect26 co-organizer Rehan Villani.
October 17, 2025 at 6:10 PM
brotmanbaty.org/news/q-and-a... @brotmanbaty.bsky.social Q&A with #VariantEffect26 co-organizer Rehan Villani.
Reposted by Lara Muffley
Want to be our colleague? We have a faculty position in microbial systems biology looking for candidates. Please share. www.rh.ulaval.ca/emplois-disp...
Tenure-Track Faculty Position in Omics Data Analysis in the Field of Microbial Systems Biology | Ressources humaines | Université Laval
www.rh.ulaval.ca
October 9, 2025 at 9:00 AM
Want to be our colleague? We have a faculty position in microbial systems biology looking for candidates. Please share. www.rh.ulaval.ca/emplois-disp...
Reposted by Lara Muffley
Variant Effects Seminar Series
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/
October 3, 2025 at 1:50 PM
Variant Effects Seminar Series
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/
October and November lineup! Join us!
ℹ️https://www.varianteffect.org/seminar-series/
Reposted by Lara Muffley
This role, based at Sanger, will lead on the communications for the Atlas of Variant Effects Alliance - an initiative that is mapping the effects of all the possible variants of human genes 🧬
This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...
This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...
October 2, 2025 at 10:25 AM
This role, based at Sanger, will lead on the communications for the Atlas of Variant Effects Alliance - an initiative that is mapping the effects of all the possible variants of human genes 🧬
This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...
This is a part-time role, closing on 14th Oct.
More info ⤵️
sanger.wd103.myworkdayjobs.com/WellcomeSang...
Reposted by Lara Muffley
I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
October 2, 2025 at 1:47 AM
I'm stoked to be organising next year's MSS right here in beautiful Melbourne! We know Australia is very far away, and we're working hard to make sure we can support as many ECRs to attend as possible, so please do register and apply for a travel award!
@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!
We are #Hiring!
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
Communications role for our Global Alliance! 🌍🧬
Please share this post with your network, or apply if you are interested!
📍 Location: Hinxton, England
🕒 Part-time role
ℹ️ sanger.wd103.myworkdayjobs.com/en-US/Wellco...
#ScienceJobs #Communications #Genomics
#PartTimeRole #UKJobs
October 1, 2025 at 1:54 PM
@varianteffect.bsky.social @sangerinstitute.bsky.social #JobOpening This person would work closely with me. Reach out if you are interested in learning more!
Reposted by Lara Muffley
We are hiring! Communications role for our Global Alliance! sanger.wd103.myworkdayjobs.com/en-US/Wellco... #job #hiring #Communications Hinxton, Cambridgeshire UK
Scientific Communications Manager -Part Time
Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...
sanger.wd103.myworkdayjobs.com
September 30, 2025 at 7:57 PM
We are hiring! Communications role for our Global Alliance! sanger.wd103.myworkdayjobs.com/en-US/Wellco... #job #hiring #Communications Hinxton, Cambridgeshire UK
Submit your abstract for the upcoming Mutational Scanning Symposium (deadline is Nov 2nd, 2025!)
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...
📣Call for Abstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
for the Mutational Scanning Symposium! #VariantEffect26
🗓️ March 25-27, 2026
📍 Melbourne, Australia (and online!)
📝 Submit your abstract (deadline is Nov 2nd, 2025!)
➡️ Registration is also now open!!
ℹ️ www.mss2026.org
#FunctionalGenomics #Symposium #Australia #CallForAbstracts
September 26, 2025 at 1:55 PM
Submit your abstract for the upcoming Mutational Scanning Symposium (deadline is Nov 2nd, 2025!)
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...
General info: www.mss2026.org
Abstract submission form: docs.google.com/forms/d/e/1F...
Reposted by Lara Muffley
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
September 3, 2025 at 5:40 PM
Next up! Two applications of MAVE!
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.
🧬 DNA damage repair & cancer: Shelby Hemker (@jacobkitzman.bsky.social lab UMich) measures DNA repair of MUTYH variants.
🦠Antibiotic resistance: @kroman.bsky.social (@synplexity.bsky.social Univ. of Oregon) decodes how mutations drive resistance in DHFR.