Kyrie Pappas, PhD
@kyriepappas.bsky.social
Senior Research Scientist at Memorial Sloan Kettering Cancer Center
Cancer Biologist | Translational Research | Drug Discovery | Targeted Therapy | Biomarker Research
Cancer Biologist | Translational Research | Drug Discovery | Targeted Therapy | Biomarker Research
Reposted by Kyrie Pappas, PhD
OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L
Nature Genetics - Lineage tracing in mice identifies a subpopulation of basal cells that express Tmprss2 and Nkx3 as the origin of ERG-driven prostate cancer. Upon expansion, these cells show an...
rdcu.be
September 8, 2025 at 3:38 PM
OUT NOW: ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L rdcu.be/eEVKR @mskcancercenter.bsky.social @natureportfolio.nature.com #SawyersLabMSKCC
Excited to share our recent work published in PNAS last week uncovering the molecular mechanisms of PARP inhibitor resistance in BRCA2-deficient metastatic castration-resistant prostate cancer (mCRPC). Check out our manuscript!
Just out: BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function | PNAS www.pnas.org/doi/10.1073/... @mskcancercenter.bsky.social @kyriepappas.bsky.social #SawyersLabMSKCC
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
June 12, 2025 at 2:51 AM
Excited to share our recent work published in PNAS last week uncovering the molecular mechanisms of PARP inhibitor resistance in BRCA2-deficient metastatic castration-resistant prostate cancer (mCRPC). Check out our manuscript!