Author | Lightnews

Reposted by Kris Kilian

Emily R. Trunnell, Ph.D. @ertrunnell.bsky.social · 1d

In this review, @gsilvani.bsky.social, Martina Stenzel, & @kriskilian.bsky.social of @nanomed-unsw.bsky.social discuss how advances in #organoids & perfusable MPS are transforming nanoparticle design & accelerating nanodrug development by enabling more predictive assessments of efficacy.

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Kris Kilian @kriskilian.bsky.social · Sep 8

Featured in #UNSW press.

www.unsw.edu.au/newsroom/new...

Squeezing through blood vessels helps melanoma cells survive and thrive

When detached cancer cells squeeze through the tiniest blood vessels they can become prone to grow new tumours far from where they started, a blood flow simulation experiment suggests.

www.unsw.edu.au

Kris Kilian @kriskilian.bsky.social · Sep 8

Interested in mechanical forces influencing phenotype plasticity? Check out our latest work, led by Giulia Silvani, where we used microfluidic models to explore #melanoma cells transiting tight spaces—constriction induced invasiveness and tumorigenicity…
www.nature.com/articles/s41...

Capillary constrictions prime cancer cell tumorigenicity through PIEZO1 - Nature Communications

Cancer cells can squeeze through confined spaces and undergo nuclear deformation, leading to changes in chromatin organisation. Here, the authors show that mechanical constriction in microcapillaries ...

www.nature.com

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Kris Kilian @kriskilian.bsky.social · Aug 2

Thanks for the shout out @epimechfc.bsky.social — ♥️ micropatterning and the insights we can gain with this technique! 🤩

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Reposted by Kris Kilian

Manuel Thery @manuelthery.bsky.social · Jul 29

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Head of the Cell Biology and Biophysics Unit

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

embl.wd103.myworkdayjobs.com

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Kris Kilian @kriskilian.bsky.social · Jul 27

Work needs to be tempered with play. Some of my best ideas have come from introspective mountain time. I thought I needed a new ski jacket, but alas @nanomed-unsw.bsky.social had me covered 🤩 #acn #nanomedicine #treblecone #wanaka 🇳🇿🏂❄️

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Kris Kilian @kriskilian.bsky.social · Jul 6

Hot off the press! Exploring phenotype plasticity in confined spheroids @nanomed-unsw.bsky.social

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface - Soliman - Advanced Science - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/10.1002/...

Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface

Drop-on-demand printing is used to replicate the spatial compartmentalization of the breast cancer-host interface. Hydrogel confinement affects phenotypic changes in cells at the spheroid interface t...

advanced.onlinelibrary.wiley.com

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Kris Kilian @kriskilian.bsky.social · Jun 24

Thanks mate! Glad you like it 😃

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Reposted by Kris Kilian

Andrew Holle @ahcells.bsky.social · Jun 24

Interested in a #postdoc on nuclear #mechanobiology? We have a fully funded position in the Confinement Mechanobiology Lab designed to help you meet your career goals while researching the rapidly growing field of cellular #confinement. Please get in touch for more info!

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Kris Kilian @kriskilian.bsky.social · Jun 24

Check out our latest paper —a new approach to pore analysis in hydrogels

Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications - Tolentino - Advanced Healthcare Materials - Wiley Online Library advanced.onlinelibrary.wiley.com/doi/full/10....

Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications

Porosity governs transport mechanics in hydrogels, yet characterization in its native state remains challenging. This work harnesses particle tracking to uncover three-dimensional pore geometric feat...

advanced.onlinelibrary.wiley.com

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Reposted by Kris Kilian

UNSW Australian Centre for NanoMedicine (ACN) @nanomed-unsw.bsky.social · Jun 17

A great first morning session yesterday to kick off our 15th International Nanomedicine Conference. We had an outstanding talk from our first plenary speaker, Chris Porter, and our keynote and invited speakers.

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Reposted by Kris Kilian

UNSW Australian Centre for NanoMedicine (ACN) @nanomed-unsw.bsky.social · Jun 17

Day 2 of our International #Nanomedicine Conference. We kicked off with a great plenary from Kate Schroder showcasing her work on #inflammasomes. Followed by more fantastic talks. #drugdelivery #biosensors @mknanomedicine.bsky.social @kriskilian.bsky.social @yingzhu.bsky.social

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Kris Kilian @kriskilian.bsky.social · May 9

Hot off the press!
Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides | ACS Macro Letters pubs.acs.org/doi/10.1021/...

Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides

Peptide self-assembly has been used to fabricate synthetic hydrogels that emulate many of the chemical and physical properties of natural hydrogels. However, these materials often lack stability for m...

pubs.acs.org

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Reposted by Kris Kilian

UNSW Australian Centre for NanoMedicine (ACN) @nanomed-unsw.bsky.social · May 8

Prof Kris Kilian @kriskilian.bsky.social a SMART CRC CI & co-Director of the Australian Centre for NanoMedicine, said that he hopes the SMART CRC will provide opportunities for future projects, where ideas from the lab can become real life treatments and products.

www.unsw.edu.au/news/2025/05...

UNSW and partners to receive millions to transform regenerative medicine

The University of New South Wales will be a key beneficiary of a $65 million government grant aimed at making Australia a regenerative medicine powerhouse.

www.unsw.edu.au

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Reposted by Kris Kilian

Peter Wich - Wichlab @peterwich.bsky.social · Apr 22

Great talks in the #cancer session at #ASBTE2025 in Brisbane by Sara Romanazzo and Bram Soliman from the Lab of @kriskilian.bsky.social on 3D tissue models for cancer-associated fibroblasts and the mimicry of cancer-cell interfaces.

@asbte.bsky.social #biopolymers #hydrogels #bioprinting

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Kris Kilian @kriskilian.bsky.social · Mar 17

I am looking forward to working with @msde.rsc.org as Associate Editor —consider submitting your latest and greatest work in molecular systems design and engineering 🧪🥼 🧫 🤩

Molecular Systems Design & Engineering @msde.rsc.org · Mar 17

We are delighted to welcome Professor Kristopher Kilian (@kriskilian.bsky.social) to the Molecular Systems Design & Engineering Editorial Board as an Associate Editor!⭐

More information on Kris's research interest can be found on our webpage - www.rsc.org/journals-boo...

#ChemSky 🧪

Text says:
MSDE
Editorial board member
Associate Editor
Kristopher Kilian
University of New South Wales, Australia.
A head shot of Kristopher is shown.

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Reposted by Kris Kilian

ChemComm @chemcomm.rsc.org · Mar 4

#RSCPoster gets underway in less than 4 hours over on LinkedIn.

For 24 hours you can see posters from hundreds of researchers across the globe on topics from all areas of chemistry.

Find out more at www.rsc.org/our-events/r...

RSC Poster: a global online poster conference

#RSCPoster is a global poster conference that brings the chemistry community together online over the course of 24 hours

www.rsc.org

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Kris Kilian @kriskilian.bsky.social · Jan 29

Here we demonstrate proof of concept for spatial patterning of multiple cell types using compression and light triggers. However, the concept is general and we envision wide ranging applications from tissue engineering to soft robotics. @asbte.bsky.social @unswchemistry.bsky.social

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Kris Kilian @kriskilian.bsky.social · Jan 29

We have been exploring polymer mechanochemistry to promote dynamic activities in hydrogel biomaterials.

In this new paper, we integrated 2 responsive linkages into PEG-based hydrogels, where force and light were used as triggers to change chemistry. Check it out!
pubs.rsc.org/en/content/a...

Multi-step functionalization of hydrogels through mechano- and photo-responsive linkages

Patterning soft materials with cell adhesion motifs can be used to emulate the structures found in natural tissues. While patterning in tissue is driven by cellular assembly, patterning soft materials...

pubs.rsc.org

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Kris Kilian @kriskilian.bsky.social · Jan 24

Kicking off 2025 with a Coogee beach BBQ —great to hang out with these legends outside of the lab….maybe a new group meeting spot 🧐🏝️ 🥳

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Kris Kilian @kriskilian.bsky.social · Jan 11

I know right? Check it out! Pretty interesting materials properties..:

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Kris Kilian @kriskilian.bsky.social · Jan 11

We developed a simple and effective way to instil some viscoelasticity, durability and bioactivity in PEG-based hydrogels, through inclusion of a self-assembling peptide network. These peptides are are an awesome additive to expand hydrogel functionality! 🤩
pubs.rsc.org/en/content/a...

Improving the bioactivity and mechanical properties of poly(ethylene glycol)-based hydrogels through a supramolecular support network

Most synthetic hydrogels are formed through radical polymerization to yield a homogenous covalent meshwork. In contrast, natural hydrogels form through mechanisms involving both covalent assembly and ...

pubs.rsc.org

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Kris Kilian @kriskilian.bsky.social · Jan 8

doi.org/10.1063/5.02...

Stem cell mechanoadaptation. II. Microtubule stabilization and substrate compliance effects on cytoskeletal remodeling

Stem cells adapt to their local mechanical environment by rearranging their cytoskeleton, which underpins the evolution of their shape and fate as well as the e

doi.org

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Kris Kilian @kriskilian.bsky.social · Jan 8

doi.org/10.1063/5.02...

Stem cell mechanoadaptation. I. Effect of microtubule stabilization and volume changing stresses on cytoskeletal remodeling

Here, we report on the first part of a two-part experimental series to elucidate spatiotemporal cytoskeletal remodeling, which underpins the evolution of stem c

doi.org

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