Happy to share our latest in @natcomputsci.nature.com
led by (amazing) Ryan Krueger + colab w M. Brenner!

We introduce a framework to directly design intrinsically disordered proteins (IDPs) from physics-based simulations.
🧬 doi.org/10.1038/s435...
📰 www.mccormick.northwestern.edu/news/article...

Coupling and decoupling of the cell cycle from cell differentiation in development

In this Spotlight, @kkukreja.bsky.social & Allon Klein discuss the dependence of animal cell differentiation on cell cycle, and how their decoupling facilitates development

journals.biologists.com/dev/article-...

Thank you so much @amjeve.bsky.social , @biologists.bsky.social and @dev-journal.bsky.social for the opportunity and for all the help with the piece.
(3/3)

This is my 1st publication with Development & it was such a pleasure. Nt only did reviewers provide v. constructive comments, the Editor himself (Alex Eve) also read the paper carefully & gave us very useful suggestions to improve the readability of this piece.
(2/3)

Our review on cell cycle – cell fate (de)coupling is out! doi.org/10.1242/dev....
Was a lot of fun writing this with Allon Klein, reading old papers(earliest from 1902), and speculating on why cell cycle progression is not necessary for differentiation across many many tissues and species.
(1/3)

📢 @shrinivaslab.bsky.social and colleagues introduce a method for designing unstructured proteins with tunable properties. www.nature.com/articles/s43... 🖥️ 🧬

🔓 rdcu.be/eJSuV

Preprint!

Inspired by condensates that form on specific DNA, we ask:

can we design multicomponent fluids to form distinct condensates on diff. surfaces?

i.e. perform classification by condensation ⚛️ 💻 exploiting phase transitions beyond compartmentalization!
arxiv.org/abs/2509.08100
(1/2)

New in @pnas.org with @gladfelterlab.bsky.social @sneadlab.bsky.social ! 📢

Cells use condensates (dynamic compartments without membranes) to organize key reactions. Some condensates have core & shell layers… but how do such layers form? 🤔

👉 pnas.org/doi/10.1073/pnas.2504778122 (1/6)

Excited to share our latest by my postdoc Ben KS: we use statistical physics & Bayesian inference to model genome-wide perturbation outcomes. Remarkably, perturbation responses are encoded in gene "chatter" even before the perturbation–a fundamental insight with broad implications
shorturl.at/2LHbw

Excited to share our paper on deciphering the design & control principles of tissue scaling w/ Luisa Arispe! Amazing work by co-first authors Danielle Pi and Jonas Braun. We show *differentiated* endothelial cell proliferate in waves with ultrafast cell cycle time of ~5h
www.cell.com/cell-systems...

Loved this! Using devbio to engineer embryo models with notochord – neat and cool study. Lot of careful characterization of the embryo model.

this image was captured and edited by Bill Jia🙏 in Sean Megason's lab as we were working on a revision experiment to quantify cell division arrest in mutant zebrafish embryos!

Also thanks to @rikkigarner.bsky.social for cover suggestions.

Happy Holidays ⛄

2/2

My first post on bluesky!!

Excited to see my PhD work featured on the cover of NCB @naturecellbiology.bsky.social December issue! This image shows a gorgeous #zebrafish embryo undergoing cell division (the green cells with condensed chromatin)—a fundamental process we study in development.

🧵1/2

Really liked reading this interview with @karalmckinley.bsky.social , so frank and honest! My favorite part "I think it's easy to get caught up in saying what we think is ‘the right thing’ to succeed, so much so that we can lose sight of what we are truly passionate about".

🔊
We are recruiting PhD students and Postdocs!

We are seeking highly motivated, talented, and creative researchers, with strong background in cell and developmental biology, who are looking to spearhead original interdisciplinary investigations, addressing overlooked biology.

1/5

can I be added too plz?

Thanks @trayon.bsky.social !! So glad you liked it :)

New work from @kkukreja.bsky.social & Klein Lab

🥂Congratulations to Klein & co for their new study in our journal (@naturecellbiology.bsky.social) showing that blocking cell division does not affect major cell type differentiation during development, but it does decelerate differentiation of particular cell types.
rdcu.be/d0Ry3

would like to be added ✋ thank you!!

yes please add ✋ thank you

postdoc in devbio. worked with zebrafish in PhD. please add me :)