Shubharthi Kar
@karnephro.bsky.social
860 followers 300 following 55 posts
Nephrologist #Bangladesh #ISNeducation #SOME Social Media Team Member #SARB #SACA member International Society of Hypertension
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Shubharthi from Bangladesh. No COI. #NephJC
Reposted by Shubharthi Kar
🎬 Share your story! Submit your short film for the 2026 #ISNFilmEvent — real stories from those affected by kidney disease and their care teams. Open to ISN members. Deadline: Nov 5 (midnight CET).
🎥 Info & submissions ➡️ http://lite.spr.ly/6... #ThisIsISN #ISNWCN
Reposted by Shubharthi Kar
1/ July 16 is #WorldSnakeDay - raising awareness of the incredible diversity of snakes and their vital role in our ecosystems. But did you know snakebites can also cause acute kidney injury? Join me, Dr. Fong Voon Ken, as we discuss their impact, management, and the need for awareness.
Reposted by Shubharthi Kar
𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike!
⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf
Reposted by Shubharthi Kar
📢 The kidney community urges UN Member States to include kidney disease in the 2025 Political Declaration on NCDs & Mental Health.

🧬 850M affected
📈 5th leading cause of death by 2050
💡 Early care = 45% cost savings

📄 Read the letter: www.theisn.org/wp-co... #KidneyHealthMatters #HLM4 #NCDs
Reposted by Shubharthi Kar
Interesting data from Alberta

www.kidney-international.org/article/S008... in @kidneyint.bsky.social

GFR < 15 is classified as ‘kidney failure’ in most studies - but about a third of them die before starting RRT.

Is that glass half full or half empty? 🥃

#NephSky
Visual abstract - still needs work since KI doesn’t get professionals to do it! 🤷🏽‍♂️
⚡️Let’s have a closer look at the associations of each of these antigens
#ECNeph
@arvindcanchi.bsky.social
indianjnephrol.org/an-updated-r...
⚡️PLA2R antibody seropositivity doesn’t mean that we do not investigate for underlying malignancies.
Here is a Case Report showing PLA2rAb MN having Carcinoma Oesophagus
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
KDIGO recommends Population and Age-appropriate Screening for malignancies irrespective of antigen status
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
3 approaches Contd
2. Panel approach: Alternatively, a laboratory could employ a standard panel of antibodies for antigens that can vary depending on volume and demographics
3. Proteomic approach: Laser microdissection of MN glomeruli, followed by mass spectrometry. #ECneph
3 approaches suggested by the Mayo clinic consensus report
1. Targeted approach: Perform antigen testing based on clinical disease association
Cont #ECNeph
www.kidney-international.org/article/S008...
👉 🫣 Can IF differentiate from Primary and Secondary MN?
IgG 4 is the dominant class in primary MN
👉 IgG1,IgG2, IgG3 are dominant Immunoglobulins in Secondary MN

#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
👉 MN is a pattern of glomerular injury
👉 Deposition of immune complex along subepithelial aspect of GBM
👉 On Light Microscopy GBM is thickened. GBM spikes or holes can be seen
👉 IHC/IF shows IgG with C3 along capillary wall
#ECNeph
@theisn.org @dramiliflores.bsky.social @arvindcanchi.bsky.social
If it is malignancy associated MN then no role of IS. Treatment of cancer is priority #ECneph
👉 5-22 % of Adults having Membranous Nephropathy had been diagnosed malignancy within a few years of the MN Diagnosis
👉 Lung, Colon, Breast, Stomach, Prostate cancers are commonest
www.kidney-international.org/article/S008...
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social
Membranous Nephropathy and Malignancy — a deadly duo ☠️
👉 Let’s start with some trivia
❓How many older adults develop malignancy post diagnosis of Membranous Nephropathy?
A. < 1%
B. 5% - 22%
C. 30% - 40%
D. > 50%
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social
❓ How do we treat cancer associated MN?
👉 RAAS Inhibition
👉 Statin
👉 Anticoagulants as needed
👉 Specific treatment for cancer
#ECNeph
@theisn.org @myadla.bsky.social @dramiliflores.bsky.social @arvindcanchi.bsky.social
Different types of tumor secrete different types of antigen.
Here is the proposed mechanism of malignancy associated MN. #ECneph
@dramiliflores.bsky.social @myadla.bsky.social @theisn.org

www.frontiersin.org/journals/med...