Neonatal World
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The NeoVitaA study evaluated the long-term effects of early high-dose enteral vitamin A supplementation in ELBW infants. At 24 months, no benefit was observed for pulmonary infections or neurodevelopmental outcomes. A disappointing result.
#Neosky #pedsky
www.thelancet.com/journals/ecl...
#Neosky #pedsky
www.thelancet.com/journals/ecl...
Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial
Early postnatal high-dose enteral fat-soluble vitamin A supplementation in ELBW infants
did not affect pulmonary or developmental outcomes at 24 months’ CA.
www.thelancet.com
December 15, 2025 at 7:26 AM
The NeoVitaA study evaluated the long-term effects of early high-dose enteral vitamin A supplementation in ELBW infants. At 24 months, no benefit was observed for pulmonary infections or neurodevelopmental outcomes. A disappointing result.
#Neosky #pedsky
www.thelancet.com/journals/ecl...
#Neosky #pedsky
www.thelancet.com/journals/ecl...
Not all monitors are created equal.
In NICUs, we make critical decisions based on numbers — SpO₂, HR, etc. — assuming our tools are equally accurate. A new study found significant performance gaps between two commonly used pulse-ox systems.
#Neosky #pedsky
www.nature.com/articles/s41...
In NICUs, we make critical decisions based on numbers — SpO₂, HR, etc. — assuming our tools are equally accurate. A new study found significant performance gaps between two commonly used pulse-ox systems.
#Neosky #pedsky
www.nature.com/articles/s41...
Identifying performance differences between two pulse oximetry systems in simulated critical neonatal conditions - Journal of Perinatology
Journal of Perinatology - Identifying performance differences between two pulse oximetry systems in simulated critical neonatal conditions
www.nature.com
December 7, 2025 at 8:27 AM
Not all monitors are created equal.
In NICUs, we make critical decisions based on numbers — SpO₂, HR, etc. — assuming our tools are equally accurate. A new study found significant performance gaps between two commonly used pulse-ox systems.
#Neosky #pedsky
www.nature.com/articles/s41...
In NICUs, we make critical decisions based on numbers — SpO₂, HR, etc. — assuming our tools are equally accurate. A new study found significant performance gaps between two commonly used pulse-ox systems.
#Neosky #pedsky
www.nature.com/articles/s41...
A study of 15,102 infants (23–28 weeks GA) found that each 1-week delay in reaching full enteral feeds (≥120 mL/kg/day) was linked to:
+16% risk of sepsis (ARR 1.16)
Higher NEC risk (ARR 1.20)
More growth faltering in weight, length, and HC.
#Neosky #pedsky
jamanetwork.com/journals/jam...
+16% risk of sepsis (ARR 1.16)
Higher NEC risk (ARR 1.20)
More growth faltering in weight, length, and HC.
#Neosky #pedsky
jamanetwork.com/journals/jam...
Time to Full Enteral Feeds and Late-Onset Sepsis in Extremely Preterm Infants
This cohort study of extremely preterm infants evaluates whether there is an association between full enteral feeding and late-onset sepsis, necrotizing enterocolitis, and growth faltering.
jamanetwork.com
November 30, 2025 at 6:09 PM
A study of 15,102 infants (23–28 weeks GA) found that each 1-week delay in reaching full enteral feeds (≥120 mL/kg/day) was linked to:
+16% risk of sepsis (ARR 1.16)
Higher NEC risk (ARR 1.20)
More growth faltering in weight, length, and HC.
#Neosky #pedsky
jamanetwork.com/journals/jam...
+16% risk of sepsis (ARR 1.16)
Higher NEC risk (ARR 1.20)
More growth faltering in weight, length, and HC.
#Neosky #pedsky
jamanetwork.com/journals/jam...
#Neosky #pedsky
this study produced a model that can safely reduce ROP screens. Trained on >100k infants and validated on >25k, the model has AUROC 0.916. With 100% sensitivity, NPV was 99.9% and screens dropped 12%. A good tool to improve risk-stratification.
pubmed.ncbi.nlm.nih.gov/41252350/
this study produced a model that can safely reduce ROP screens. Trained on >100k infants and validated on >25k, the model has AUROC 0.916. With 100% sensitivity, NPV was 99.9% and screens dropped 12%. A good tool to improve risk-stratification.
pubmed.ncbi.nlm.nih.gov/41252350/
Machine Learning Risk Prediction for Treated Retinopathy of Prematurity in Infants - PubMed
ML models can effectively predict the need for ROP treatment and stratify infants by risk, potentially reducing unneeded screening. Future work is needed to translate model-based ROP predictions to the clinical setting.
pubmed.ncbi.nlm.nih.gov
November 24, 2025 at 2:50 PM
#Neosky #pedsky
this study produced a model that can safely reduce ROP screens. Trained on >100k infants and validated on >25k, the model has AUROC 0.916. With 100% sensitivity, NPV was 99.9% and screens dropped 12%. A good tool to improve risk-stratification.
pubmed.ncbi.nlm.nih.gov/41252350/
this study produced a model that can safely reduce ROP screens. Trained on >100k infants and validated on >25k, the model has AUROC 0.916. With 100% sensitivity, NPV was 99.9% and screens dropped 12%. A good tool to improve risk-stratification.
pubmed.ncbi.nlm.nih.gov/41252350/
A pilot study evaluated whether hyperglycemia and HbA1c levels can predict severe ROP. It found that a 30-day mean glucose of ~ 5.2 mmol/L with HbA1c of 5.6% predicted severe ROP with a 94% PPV. Another step toward improving ROP prevention.
#Neosky #pedsky
www.frontiersin.org/journals/ped...
#Neosky #pedsky
www.frontiersin.org/journals/ped...
Frontiers | Identifying neonatal hyperglycemia thresholds in preterm infants based on retinopathy of prematurity outcomes: proof-of-concept study
PurposeNeonatal hyperglycemia significantly increases risk for retinopathy of prematurity (ROP) in preterm infants, independent of other major ROP risk facto...
www.frontiersin.org
November 21, 2025 at 4:44 PM
A pilot study evaluated whether hyperglycemia and HbA1c levels can predict severe ROP. It found that a 30-day mean glucose of ~ 5.2 mmol/L with HbA1c of 5.6% predicted severe ROP with a 94% PPV. Another step toward improving ROP prevention.
#Neosky #pedsky
www.frontiersin.org/journals/ped...
#Neosky #pedsky
www.frontiersin.org/journals/ped...
3/3
#Neosky #pedsky
Why it matters:
Vaginal birth may provide cues that jump-start immune & stress pathways.
C-section infants might miss this activation window, possibly contributing to slightly higher rates of asthma/allergies.
pubmed.ncbi.nlm.nih.gov/41220118/
#Neosky #pedsky
Why it matters:
Vaginal birth may provide cues that jump-start immune & stress pathways.
C-section infants might miss this activation window, possibly contributing to slightly higher rates of asthma/allergies.
pubmed.ncbi.nlm.nih.gov/41220118/
Comparative Study Showed Significant Gene Expression Differences in Newborn Infants After Vaginal and Caesarean Deliveries - PubMed
This study demonstrates that the mode of delivery significantly influences neonatal gene expression and immune system activation.
pubmed.ncbi.nlm.nih.gov
November 19, 2025 at 1:24 PM
3/3
#Neosky #pedsky
Why it matters:
Vaginal birth may provide cues that jump-start immune & stress pathways.
C-section infants might miss this activation window, possibly contributing to slightly higher rates of asthma/allergies.
pubmed.ncbi.nlm.nih.gov/41220118/
#Neosky #pedsky
Why it matters:
Vaginal birth may provide cues that jump-start immune & stress pathways.
C-section infants might miss this activation window, possibly contributing to slightly higher rates of asthma/allergies.
pubmed.ncbi.nlm.nih.gov/41220118/
2/3
#Neosky #pedsky
Key findings:
- 95 genes were more active in the vaginal-birth group
- IL-6 and IL-8 were also higher
Suggesting vaginal birth “activates” the newborn immune system.
After correction, effects weren’t significant—likely due to small sample size. Think trend, not conclusion
#Neosky #pedsky
Key findings:
- 95 genes were more active in the vaginal-birth group
- IL-6 and IL-8 were also higher
Suggesting vaginal birth “activates” the newborn immune system.
After correction, effects weren’t significant—likely due to small sample size. Think trend, not conclusion
November 19, 2025 at 1:24 PM
Accurate assessment of heart rate is critical for decision-making in the delivery room. However, the opimsl method for assessing HR in this setting is uncertain. A recent meta-analysis found that the quality of available evidence is low to very low.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Fast and accurate newborn heart rate monitoring at birth: A systematic review
To examine speed and accuracy of newborn heart rate measurement by various assessment methods employed at birth.A search of Medline, SCOPUS, CINAHL an…
www.sciencedirect.com
November 16, 2025 at 11:59 AM
Accurate assessment of heart rate is critical for decision-making in the delivery room. However, the opimsl method for assessing HR in this setting is uncertain. A recent meta-analysis found that the quality of available evidence is low to very low.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
3/3
Takeaway
Automated O₂ control improved oxygen stability and reduced key complications in preterm infants; BPD and oxygen dependency.
Larger trials are needed before routine clinical adoption.
#Neosky #Pedsky
fn.bmj.com/content/earl...
Takeaway
Automated O₂ control improved oxygen stability and reduced key complications in preterm infants; BPD and oxygen dependency.
Larger trials are needed before routine clinical adoption.
#Neosky #Pedsky
fn.bmj.com/content/earl...
Closed-loop automated oxygen control in preterm ventilated infants: a randomised controlled trial
Objective To compare the duration of mechanical ventilation between preterm infants receiving closed-loop automated oxygen control (CLAC) or manual oxygen control.
Design Randomised controlled trial....
fn.bmj.com
November 13, 2025 at 2:48 PM
3/3
Takeaway
Automated O₂ control improved oxygen stability and reduced key complications in preterm infants; BPD and oxygen dependency.
Larger trials are needed before routine clinical adoption.
#Neosky #Pedsky
fn.bmj.com/content/earl...
Takeaway
Automated O₂ control improved oxygen stability and reduced key complications in preterm infants; BPD and oxygen dependency.
Larger trials are needed before routine clinical adoption.
#Neosky #Pedsky
fn.bmj.com/content/earl...
2/3
Infants managed with CLAC had:
• Shorter ventilation (11 vs. 40 days, p=0.02)
• Less time on O₂ (33 vs. 47 days, p=0.03)
• Lower rates of BPD (55% vs. 84%, p=0.02)
• Fewer required home O₂ (27% vs. 51%, p=0.02)
CLAC reduced hypo- or hypoxemia episodes (p<0.001).
#Neosky #Pedsky
Infants managed with CLAC had:
• Shorter ventilation (11 vs. 40 days, p=0.02)
• Less time on O₂ (33 vs. 47 days, p=0.03)
• Lower rates of BPD (55% vs. 84%, p=0.02)
• Fewer required home O₂ (27% vs. 51%, p=0.02)
CLAC reduced hypo- or hypoxemia episodes (p<0.001).
#Neosky #Pedsky
November 13, 2025 at 2:39 PM
1/3
A new RCT tested closed-loop automated oxygen control (CLAC) vs. manual oxygen adjustment in preterm ventilated infants, aiming to compare how long infants stayed on mechanical ventilation.
N= 69 infants (median GA 27 wks) were randomized within 48 hours of ventilation start
#Neosky #Pedsky
A new RCT tested closed-loop automated oxygen control (CLAC) vs. manual oxygen adjustment in preterm ventilated infants, aiming to compare how long infants stayed on mechanical ventilation.
N= 69 infants (median GA 27 wks) were randomized within 48 hours of ventilation start
#Neosky #Pedsky
November 13, 2025 at 2:36 PM
2/2
Among overlapping SRs, 21% reached conflicting conclusions and 69% disagreed on evidence certainty.
Takeaway:
redundant, low-quality SRs waste resources and mislead clinicians. Every new SR should justify its purpose and follow rigorous methods.
#Neosky #pedsky
www.jclinepi.com/article/S089...
Among overlapping SRs, 21% reached conflicting conclusions and 69% disagreed on evidence certainty.
Takeaway:
redundant, low-quality SRs waste resources and mislead clinicians. Every new SR should justify its purpose and follow rigorous methods.
#Neosky #pedsky
www.jclinepi.com/article/S089...
Systematic reviews on the same topic are common but often fail to meet key methodological standards: a research-on-research study
To 1) assess the frequency of overlapping systematic reviews (SRs) on the same topic
including overlap in outcomes, 2) assess whether SRs meet some key methodological
characteristics, and 3) describe ...
www.jclinepi.com
November 10, 2025 at 1:33 PM
2/2
Among overlapping SRs, 21% reached conflicting conclusions and 69% disagreed on evidence certainty.
Takeaway:
redundant, low-quality SRs waste resources and mislead clinicians. Every new SR should justify its purpose and follow rigorous methods.
#Neosky #pedsky
www.jclinepi.com/article/S089...
Among overlapping SRs, 21% reached conflicting conclusions and 69% disagreed on evidence certainty.
Takeaway:
redundant, low-quality SRs waste resources and mislead clinicians. Every new SR should justify its purpose and follow rigorous methods.
#Neosky #pedsky
www.jclinepi.com/article/S089...
3/3
Takeaway:
Early rapid genome sequencing not only finds more answers—it saves major costs for the sickest infants.
Researchers call for expanded reimbursement to make early rGS standard care.
#Neosky #pedsky
pubmed.ncbi.nlm.nih.gov/41177396
Takeaway:
Early rapid genome sequencing not only finds more answers—it saves major costs for the sickest infants.
Researchers call for expanded reimbursement to make early rGS standard care.
#Neosky #pedsky
pubmed.ncbi.nlm.nih.gov/41177396
Rapid Genome Sequencing Compared with a Gene Panel in Critically Ill Infants with a Suspected Genetic Disorder: An Economic Evaluation - PubMed
Early rGS results in substantial healthcare cost savings, highlighting the need to expand reimbursement to improve access early in a hospitalization for critically ill infants.
pubmed.ncbi.nlm.nih.gov
November 9, 2025 at 6:44 PM
3/3
Takeaway:
Early rapid genome sequencing not only finds more answers—it saves major costs for the sickest infants.
Researchers call for expanded reimbursement to make early rGS standard care.
#Neosky #pedsky
pubmed.ncbi.nlm.nih.gov/41177396
Takeaway:
Early rapid genome sequencing not only finds more answers—it saves major costs for the sickest infants.
Researchers call for expanded reimbursement to make early rGS standard care.
#Neosky #pedsky
pubmed.ncbi.nlm.nih.gov/41177396
1/3
New study (GEMINI) compares two ways to diagnose genetic disorders in critically ill infants:
1- Early rapid genome sequencing (rGS) for all
2- Targeted neonatal sequencing (NewbornDx) + later rGS if needed
Goal: find which approach saves more & helps faster.
#Neosky #pedsky
New study (GEMINI) compares two ways to diagnose genetic disorders in critically ill infants:
1- Early rapid genome sequencing (rGS) for all
2- Targeted neonatal sequencing (NewbornDx) + later rGS if needed
Goal: find which approach saves more & helps faster.
#Neosky #pedsky
November 9, 2025 at 6:42 PM
Constructive feedback
November 9, 2025 at 2:57 PM
Constructive feedback
2/2
#pedsky
#Neosky
Although PA was "more" common in this age group, it was not a key driver of outcomes; no significant association with mortality, IVH, or NDIs.
pubmed.ncbi.nlm.nih.gov/41150609/
#pedsky
#Neosky
Although PA was "more" common in this age group, it was not a key driver of outcomes; no significant association with mortality, IVH, or NDIs.
pubmed.ncbi.nlm.nih.gov/41150609/
The incidence and outcomes of perinatal asphyxia in spontaneous extreme preterm birth: a retrospective cohort study - PubMed
PA occurred more frequently in this extreme preterm cohort than in term neonates, yet did not independently influence mortality or morbidity. A major limitation is the use of ACOG criteria, originally developed for term births, which may have led to over- or underestimation of PA's true incidence an …
pubmed.ncbi.nlm.nih.gov
November 8, 2025 at 10:10 AM
2/2
#pedsky
#Neosky
Although PA was "more" common in this age group, it was not a key driver of outcomes; no significant association with mortality, IVH, or NDIs.
pubmed.ncbi.nlm.nih.gov/41150609/
#pedsky
#Neosky
Although PA was "more" common in this age group, it was not a key driver of outcomes; no significant association with mortality, IVH, or NDIs.
pubmed.ncbi.nlm.nih.gov/41150609/
A recent meta-analysis of 12 RCTs with 2,428 preterm infants of varying gestational ages, evaluated the effect of budesonide mixed with surfactant on the incidence of BPD.
The verdict? Yes, But...
pubmed.ncbi.nlm.nih.gov/40995944/
#Neosky
The verdict? Yes, But...
pubmed.ncbi.nlm.nih.gov/40995944/
#Neosky
Airway Administration of Budesonide Combined With Pulmonary Surfactant to Prevent Bronchopulmonary Dysplasia in Preterm Infants: A Systematic Review and Meta-Analysis - PubMed
Compared to the use of pulmonary surfactant alone, the combination of budesonide and pulmonary surfactant may prevent bronchopulmonary dysplasia in preterm infants, and does not increase the occurrence of related complications.
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:01 PM
A recent meta-analysis of 12 RCTs with 2,428 preterm infants of varying gestational ages, evaluated the effect of budesonide mixed with surfactant on the incidence of BPD.
The verdict? Yes, But...
pubmed.ncbi.nlm.nih.gov/40995944/
#Neosky
The verdict? Yes, But...
pubmed.ncbi.nlm.nih.gov/40995944/
#Neosky
In any given condition, if you elect to treat only babies who are sicker than average and reassess them after treatment, an apparent improvement will almost certainly be observed, even if the treatment has no real effect. Why?
To read more, please visit:
whatsapp.com/channel/0029...
#Neosky
To read more, please visit:
whatsapp.com/channel/0029...
#Neosky
Neonatal World | WhatsApp Channel
Neonatal World WhatsApp Channel. A place to explore the issues that matter most to newborns, their families, and those who care for them. 1K followers
whatsapp.com
November 7, 2025 at 9:29 AM
In any given condition, if you elect to treat only babies who are sicker than average and reassess them after treatment, an apparent improvement will almost certainly be observed, even if the treatment has no real effect. Why?
To read more, please visit:
whatsapp.com/channel/0029...
#Neosky
To read more, please visit:
whatsapp.com/channel/0029...
#Neosky
Neonatal World
A place to explore the issues that matter most to newborns, their families, and those who care for them.
Please visit:
whatsapp.com/channel/0029...
#Neosky
A place to explore the issues that matter most to newborns, their families, and those who care for them.
Please visit:
whatsapp.com/channel/0029...
#Neosky
Neonatal World | WhatsApp Channel
Neonatal World WhatsApp Channel. A place to explore the issues that matter most to newborns, their families, and those who care for them. 1K followers
whatsapp.com
November 7, 2025 at 9:08 AM
Neonatal World
A place to explore the issues that matter most to newborns, their families, and those who care for them.
Please visit:
whatsapp.com/channel/0029...
#Neosky
A place to explore the issues that matter most to newborns, their families, and those who care for them.
Please visit:
whatsapp.com/channel/0029...
#Neosky
