Jonathan VanRyzin
@jwvanryzin.bsky.social
Postdoc at UNC Chapel Hill | Astrocytes and microglia in development and disease | Stress, Social Behavior, Addiction | On the job market
Reposted by Jonathan VanRyzin
Very glad to share our newest paper published in Molecular Psychiatry: Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention www.nature.com/articles/s41... fun collab w/ @jordanmarrocco.bsky.social. Please enjoy! #OpenAccess #MaternalHealth
www.nature.com
November 17, 2025 at 5:38 PM
Very glad to share our newest paper published in Molecular Psychiatry: Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention www.nature.com/articles/s41... fun collab w/ @jordanmarrocco.bsky.social. Please enjoy! #OpenAccess #MaternalHealth
Reposted by Jonathan VanRyzin
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...
November 11, 2025 at 10:55 AM
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! www.biorxiv.org/content/10.1...
Reposted by Jonathan VanRyzin
Reposted by Jonathan VanRyzin
New preprint from the lab! We identified Vipr2-expressing BNST neurons as a distinct subpopulation of the oval nucleus that promotes feeding, is activated by food restriction, is non-overlapping with appetite-suppressing PKC delta neurons, and projects to PSTN & PVN hypothalamic feeding centers.
November 11, 2025 at 4:39 PM
New preprint from the lab! We identified Vipr2-expressing BNST neurons as a distinct subpopulation of the oval nucleus that promotes feeding, is activated by food restriction, is non-overlapping with appetite-suppressing PKC delta neurons, and projects to PSTN & PVN hypothalamic feeding centers.
Reposted by Jonathan VanRyzin
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Estrogen modulates reward prediction errors and reinforcement learning - Nature Neuroscience
Dopamine encoding of reward prediction errors naturally fluctuates over females’ reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins.
www.nature.com
November 11, 2025 at 2:41 PM
Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41...
#blueprint 1/7
#blueprint 1/7
Reposted by Jonathan VanRyzin
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology
go.nature.com/4p2hyua
go.nature.com/4p2hyua
How genetically encoded sensors have lit up neuroscience
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology — although important caveats remain.
go.nature.com
November 11, 2025 at 11:38 AM
Tools that track specific molecules in neurons have enabled researchers to probe previously unexplored aspects of neurobiology
go.nature.com/4p2hyua
go.nature.com/4p2hyua
Can say that I've done this previously with my rats and it's 100% worth it to "hear" them giggle with a USV microphone 🤣
🐀Male and female rats like to be tickled differently - males prefer rougher play.
🤣How do we know? Rats produce ultrasonic giggles that can be monitored with a bat detector.
🧪Why is this relevant? To improve lab animal welfare.
Ah, to tickle rats for a living...♥️
f1000research.com/articles/14-...
🤣How do we know? Rats produce ultrasonic giggles that can be monitored with a bat detector.
🧪Why is this relevant? To improve lab animal welfare.
Ah, to tickle rats for a living...♥️
f1000research.com/articles/14-...
November 11, 2025 at 1:59 PM
Can say that I've done this previously with my rats and it's 100% worth it to "hear" them giggle with a USV microphone 🤣
Reposted by Jonathan VanRyzin
Check out our latest, online now at @sfnjournals.bsky.social www.jneurosci.org/content/earl...
Superior colliculus projections drive dopamine neuron activity and movement but not value
To navigate dynamic environments, animals must rapidly integrate sensory information and respond appropriately to gather rewards and avoid threats. It is well established that dopamine (DA) neurons in...
www.jneurosci.org
October 15, 2025 at 8:39 PM
Check out our latest, online now at @sfnjournals.bsky.social www.jneurosci.org/content/earl...
Reposted by Jonathan VanRyzin
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Fig. 1: Establishment of methods to identify astrocyte endfoot proteins. | Nature Communications
www.nature.com
November 6, 2025 at 11:26 AM
Finally it’s here! 🌟⬇️
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
www.nature.com/articles/s41...
I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?
Reposted by Jonathan VanRyzin
Science friends! I need your help. We have a Neurophotometrics FP system that we are having trouble integrating with behavioral tracking software for annotation purposes. For example, we want to align fluorescence with open/closed arm exploration in the EPM. Can you help us out??
September 11, 2025 at 8:47 PM
Science friends! I need your help. We have a Neurophotometrics FP system that we are having trouble integrating with behavioral tracking software for annotation purposes. For example, we want to align fluorescence with open/closed arm exploration in the EPM. Can you help us out??
Reposted by Jonathan VanRyzin
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
September 12, 2025 at 1:21 PM
Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”
This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.
🔗 www.cell.com/cell/fulltex...
Faust et al., Cell 2025
Reposted by Jonathan VanRyzin
Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities
Prenatal stress (PNS) is a well-established risk factor for psychiatric disorders, yet the underlying neurobiological mechanisms remain unclear. Here,…
www.sciencedirect.com
August 26, 2025 at 9:55 AM
Prenatal stress induces transient developmental alterations in distinct GABAergic populations and leads to long-lasting behavioral abnormalities
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Jonathan VanRyzin
Excited my PhD work in @brianmathur.bsky.social’s lab is now published and available!
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum
doi.org/10.1038/s414...
doi.org/10.1038/s414...
Serotonin and psilocybin activate 5-HT1B receptors to suppress cortical signaling through the claustrum - Nature Communications
Our basic understanding of neuromodulation in the claustrum remains limited. Here Madden et al., identify a key mechanism by which serotonin and the psychedelic psilocybin modulate cortical signalling...
doi.org
August 21, 2025 at 2:40 AM
Excited my PhD work in @brianmathur.bsky.social’s lab is now published and available!
Reposted by Jonathan VanRyzin
If you have a "recently" (in the last 2 years) published paper with a preprint available, I’d love to hear from you!
All neuroscience topics are welcome.
🙏🏼 Thank you!
All neuroscience topics are welcome.
🙏🏼 Thank you!
I’m designing a course that uses preprints and their peer-reviewed, published versions to directly compare how manuscripts are originally conceived by authors and how the peer-review process shapes their final form.🎯My goal is to help students strengthen critical thinking and become fair reviewers.
August 14, 2025 at 11:20 AM
If you have a "recently" (in the last 2 years) published paper with a preprint available, I’d love to hear from you!
All neuroscience topics are welcome.
🙏🏼 Thank you!
All neuroscience topics are welcome.
🙏🏼 Thank you!
I am SO EXCITED to share this one! The latest paper from the lab is online in @cp-cellreports.bsky.social. We show microglia prune NAc astrocyte processes during abstinence from cocaine-self ad which drives later drug seeking behavior.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Abstinence from cocaine self-administration promotes microglial pruning of astrocytes, which drives cocaine-seeking behavior
Rodent drug self-administration leads to a compromised ability of nucleus accumbens astrocytes to maintain glutamate homeostasis as well as to reducti…
www.sciencedirect.com
August 13, 2025 at 6:48 PM
I am SO EXCITED to share this one! The latest paper from the lab is online in @cp-cellreports.bsky.social. We show microglia prune NAc astrocyte processes during abstinence from cocaine-self ad which drives later drug seeking behavior.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Incredibly grateful to be one of the 2025 BBRF Young Investigator Grant awardees!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!
August 6, 2025 at 7:01 PM
Incredibly grateful to be one of the 2025 BBRF Young Investigator Grant awardees!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!
Thank you to @bbrfoundation.bsky.social and to my mentors for their support along the way!
Reposted by Jonathan VanRyzin
Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early-life stress
Neuropsychopharmacology - Epigenetic regulation of brain development, plasticity, and response to early-life stress
rdcu.be
August 6, 2025 at 3:38 PM
Review now out in @npp-journal.bsky.social!
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Epigenetic regulation of brain development, plasticity, and response to early life stress
rdcu.be/ezzYq
Reposted by Jonathan VanRyzin
#ThisWeekInNPP
This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social
This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social
Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology
Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala
www.nature.com
August 5, 2025 at 5:39 PM
#ThisWeekInNPP
This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social
This study explored how prenatal & postnatal THC exposure affects 🧠 development & social behavior in 🐭, highlighting an impact on microglial phagocytosis in the developing amygdala in a sex-specific & timing-dependent manner ⏲️ / @jwvanryzin.bsky.social
Excited to see our most recent project published in @npp-journal.bsky.social !
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!
www.nature.com/articles/s41...
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!
www.nature.com/articles/s41...
Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology
Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala
www.nature.com
July 29, 2025 at 3:09 PM
Excited to see our most recent project published in @npp-journal.bsky.social !
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!
www.nature.com/articles/s41...
We show that the timing of THC exposure during development—prenatal vs. postnatal—leads to opposite effects on social behavior and microglial function in the amygdala. Timing matters!
www.nature.com/articles/s41...
Reposted by Jonathan VanRyzin
Excited to announce our latest production! @jwvanryzin.bsky.social @aemarquardt.bsky.social @um-mind.bsky.social www.nature.com/articles/s41...
Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala - Neuropsychopharmacology
Neuropsychopharmacology - Timing matters: modeling the effects of gestational cannabis exposure on social behavior and microglia in the developing amygdala
www.nature.com
July 23, 2025 at 3:13 PM
Excited to announce our latest production! @jwvanryzin.bsky.social @aemarquardt.bsky.social @um-mind.bsky.social www.nature.com/articles/s41...
Happy #FluorescenceFriday !
Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.
Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.
November 22, 2024 at 1:54 PM
Happy #FluorescenceFriday !
Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.
Sharing one of my favorite images I've taken of microglia phagocytosis featuring a neuron whose DAPI is all too happy to be eaten.
Reposted by Jonathan VanRyzin
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
November 14, 2024 at 3:21 AM
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
I've been trying something a bit different on the microscope lately. Looking at ways we can model physical interactions of astrocytes with specific neural circuits across development.
November 14, 2024 at 2:54 PM
I've been trying something a bit different on the microscope lately. Looking at ways we can model physical interactions of astrocytes with specific neural circuits across development.
Finally made the migration!
To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!
To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!
November 12, 2024 at 9:02 PM
Finally made the migration!
To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!
To any new faces, I'm Jon and I'm a postdoc at UNC studying microglia, astrocytes, brain development, stress, and addiction. I'm also on the job market!