Jun Ishigohoka
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junishigohoka.bsky.social
Jun Ishigohoka
@junishigohoka.bsky.social
190 followers 240 following 43 posts
Evolutionary biologist

Tübingen < Plön < Kiel < Sapporo < Tokyo
https://junishigohoka.github.io/
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junishigohoka.bsky.social
Jun Ishigohoka @junishigohoka.bsky.social · Jan 27
Happy to share our new paper OA in Genetics. We show that population genomic methods based on ARGs (ancestral recombination graphs i.e. genetic ancestry along chromosomes) for demography inference can be biased when applied to genomes with wide high-recombining regions. doi.org/10.1093/gene...
High-recombining genomic regions affect demography inference based on ancestral recombination graphs
Abstract. Multiple methods of demography inference are based on the ancestral recombination graph. This powerful approach uses observed mutations to model
doi.org
Reposted by Jun Ishigohoka
pdevillemereuil.bsky.social
Took me a year (😱), but I finally published a blog post about our article on the #quantgen variance partition of phenitypic plasticity with @lmchev.bsky.social, published in @peercomjournal.bsky.social.

🇬🇧 devillemereuil.legtux.org/quantitative...
🇫🇷 devillemereuil.legtux.org/fr/genetique...
Quantitative genetics of reaction norms: an onion partitionning – Pierre de Villemereuil
devillemereuil.legtux.org
December 10, 2025 at 10:48 AM
Reposted by Jun Ishigohoka
relenski.bsky.social
The 2026 Guarda Summer Course in Evolutionary Biology is now accepting applications. Amazing place, amazing course, amazing opportunity for early grad students.

tb.ethz.ch/education/gu...
Summer school:<br> Evolutionary Biology in Guarda
Information about the annual summer school Evolutionary Biology in Guarda
tb.ethz.ch
December 10, 2025 at 2:24 PM
Reposted by Jun Ishigohoka
andrewstraw.bsky.social
Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too!

preprint (with videos!) + thread 🧵

Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking

www.biorxiv.org/content/10.6...

1/9
December 6, 2025 at 2:01 PM
junishigohoka.bsky.social
www.biorxiv.org/content/10.6...
An Expectation and Maximization Algorithm for Multivariate Genome-wide Association Studies (EMmvGWAS)
Genome-wide association studies (GWAS) often analyze one trait at a time, but multivariate GWAS can increase the power by leveraging trait correlations. However, existing methods struggle with high co...
www.biorxiv.org
December 5, 2025 at 9:58 PM
Reposted by Jun Ishigohoka
neuroethology.org
Textbook neurons are usually spiking. However, there exist plenty of non-spiking neurons whose information transmission is less understood. Shirahata et al. studied Ca-dynamics of non-spiking mechanosensory neurons in crickets that are sensitive to air flow.
onlinelibrary.wiley.com/doi/10.1111/...
Subcellular Information Processing in Mechanosensory Non‐Spiking Interneurons
We measured membrane potential and Ca2+ responses to airflow from different angles in cricket mechanosensory local non-spiking interneurons (LNIs). LNIs exhibited spatially heterogeneous patterns of ...
onlinelibrary.wiley.com
November 29, 2025 at 3:43 PM
Reposted by Jun Ishigohoka
yundeng.bsky.social
Work from my amazing undergrad @leyan-wang.bsky.social is just preprinted! TL;DR: If you worry that ARG methods might fail on unphased data due to phasing errors, you may not need to.

Check it out & consider reposting to support a great young scientist!
November 26, 2025 at 5:12 PM
junishigohoka.bsky.social
www.jneurosci.org/content/45/4...
The Hidden Benefits of Noise: Low-Frequency tRNS and Dynamic Visual Noise Enhance Visual Processing
Sensory and perceptual processing are inherently shaped by both internal and external noise sources. While noise is typically seen as disruptive, it can, under certain conditions, enhance the detectio...
www.jneurosci.org
November 26, 2025 at 9:54 PM
Reposted by Jun Ishigohoka
dirkmetzler.bsky.social
PhD position available for theoretical and statistical modeling in my joint @gevol.bsky.social project with @luisapallares.bsky.social on the evolution of transcriptional variability and its role in adaptation and evolutionary innovation.
See
job-portal.lmu.de/jobposting/6...
PhD candidate in biology — theoretical and statistical modeling (m/f/x)
job-portal.lmu.de
November 26, 2025 at 2:37 PM
junishigohoka.bsky.social
www.nature.com/articles/s41...
Progressive coevolution of the yeast centromere and kinetochore - Nature
Thousands of centromeres were identified and tracked across two major fungal clades, showing that new centromeres spread progressively and that the kinetochore acts as a filter to determine which new ...
www.nature.com
November 26, 2025 at 4:10 PM
junishigohoka.bsky.social
www.biorxiv.org/content/10.1...
Mean fitness is maximized in small populations under stabilizing selection on highly polygenic traits
Stabilizing selection commonly acts on complex traits that affect individual fitness. Here, we relate mean fitness under stabilizing selection to population size and trait architecture, using a simple...
www.biorxiv.org
November 19, 2025 at 6:15 PM
Reposted by Jun Ishigohoka
biorxiv-evobio.bsky.social
Parallel and non-parallel features of adaptive radiation in Yucatan pupfishes https://www.biorxiv.org/content/10.1101/2025.11.17.688971v1
November 18, 2025 at 5:35 PM
Reposted by Jun Ishigohoka
jesperboman.bsky.social
Changing Views on Speciation onlinelibrary.wiley.com/doi/10.1111/...
Changing Views on Speciation
Our understanding of speciation processes is constantly changing. Two important concepts that have influenced thinking over the long term are the isolation and the genic views of speciation. However,...
onlinelibrary.wiley.com
November 18, 2025 at 6:45 PM
Reposted by Jun Ishigohoka
mpi-evolbio.bsky.social
Big cheers from MPI for Evolutionary Biology! 🎉
Our alumna Dr. Christin Nyhoegen wins the KlarText Prize 2025 for her piece “Penicillin and a Small Dose of Mathematics.”
She shows how math helps improve antibiotic treatments and prevent resistance. 👏
#KlarTextPreis #MPIEvolBio #ScienceCommunication
November 14, 2025 at 8:26 AM
Reposted by Jun Ishigohoka
evoldir.bsky.social
Postdoc position available at Max Planck Institute, Germany, focusing on the genetic basis of polygenic traits in Drosophila. Applications due by Dec 22, 2025. More info: [email protected]. #postdoc
November 11, 2025 at 4:44 PM
junishigohoka.bsky.social
Next year Ig Nobel

Electrostatics facilitate midair host attachment in parasitic jumping nematodes | PNAS www.pnas.org/doi/10.1073/...
Electrostatics facilitate midair host attachment in parasitic jumping nematodes | PNAS
Jumping can be hazardous for entomopathogenic nematodes (EPNs) as those that fail to attach to an insect host face death by predation or starvation...
www.pnas.org
October 22, 2025 at 6:28 AM
junishigohoka.bsky.social
elifesciences.org/articles/105...
The general version of Hamilton’s rule
The flexibility of the general version of Hamilton's rule allows the rule to match the complexity of the model of social behaviour, or the complexity implied by the data.
elifesciences.org
October 17, 2025 at 10:05 PM
junishigohoka.bsky.social
A mosaic of modular variation at a single gene underpins convergent plumage coloration | Science www.science.org/doi/10.1126/...
A mosaic of modular variation at a single gene underpins convergent plumage coloration
The reshuffling of genomic variation from multiple origins is an important contributor to phenotypic diversification, yet insights into the evolutionary trajectories of this combinatorial process and ...
www.science.org
October 17, 2025 at 7:24 PM
Reposted by Jun Ishigohoka
plosbiology.org
Winter-active #herbivores struggle to get #nitrogen in winter, when dietary #protein is scarce. This study shows that winter protein restriction drives gut #microbiome remodeling in the #pika, increasing microbiome N recycling & helping maintain protein balance @plosbiology.org 🧪 plos.io/4nZ86I6
Left: A pika (almost certainly the wrong species!), photo credit Pixabay user mikieni777. Right: Proposed mechanism for urea nitrogen salvaging and relative changes during winter protein restriction. Urea endogenously produced by the liver is transported by epithelial urea transporters (UT-B) from blood into the cecal lumen where it is hydrolyzed to yield CO2 and NH3 by microbial urease. CO2 is excreted by the host and/or fixed by microbes. NH3 is absorbed by the host and converted into amino acids (AAs) and/or urea in the liver, or it used by microbes to synthesize AAs (green balls) that are incorporated into the microbial proteome or potentially absorbed by the host through amino-acid transporters (brown squares). Ultimately, the AAs are used to synthesize protein (green circles) in host tissues, thus recycling the urea nitrogen.
October 17, 2025 at 4:30 PM
Reposted by Jun Ishigohoka
mpiforbi.bsky.social
What is the genetic basis of bird migration? Find out in our next keynote lecture by Miriam Liedvogel @genmig.bsky.social, Professor of Ornithology at the Uni Oldenburg and Director of the Institute of Avian Research!

📍October 21 at 11am in House 4 in Seewiesen
Art by @somedonkey.bsky.social
October 16, 2025 at 3:29 PM
junishigohoka.bsky.social
www.biorxiv.org/content/10.1...
The demographic history, genomic variation, and transcontinental genotype-phenotype-environment map of mungbean
The breeding of mungbean, a crucial Asian legume, has been hampered by the lack of genomic resources. The International Mungbean Improvement Network (IMIN) aims to ensure global access to diverse germ...
www.biorxiv.org
October 16, 2025 at 9:03 PM
junishigohoka.bsky.social
journals.plos.org/plosbiology/...
A large-scale study across the avian clade identifies ecological drivers of neophobia
Neophobia (the aversive response to novelty) varies considerably across species and individuals, and can impact adaptability and survival. This study assesses neophobia in 1400 subjects from 136 bird ...
journals.plos.org
October 15, 2025 at 3:02 PM
Reposted by Jun Ishigohoka
luisapallares.bsky.social
We have put together a comprehensive eQTL map for D. melanogaster using thousands of genetically diverse flies 🪰🪰🪰🪰🪰 We hope this helps -as similar resources have done in yeast and humans- to understand how genetic variation 🧬 regulates complex traits variation 🪰 via transcriptional regulation ⬆️⬇️
Saturating the eQTL map in Drosophila: Genome-wide patterns of cis and trans regulation of transcriptional variation in outbred populations
Pallares et al. collect over a thousand RNA-seq and DNA samples from Drosophila melanogaster flies to investigate the genetic basis of gene expression variation. They find eQTLs for 98% of the genes a...
www.cell.com
October 14, 2025 at 12:55 PM
junishigohoka.bsky.social
www.nature.com/articles/s41...
Learned use of an innate sound-meaning association in birds - Nature Ecology & Evolution
Over 20 species of geographically and phylogenetically diverse bird species produce convergent whining vocalizations towards their respective brood parasites. Model presentation and playback experimen...
www.nature.com
October 15, 2025 at 2:57 PM
Reposted by Jun Ishigohoka
plosbiology.org
Genetic architectures of #ComplexTraits vary widely. @yuvalsim.bsky.social @jkpritch.bsky.social @gs2747.bsky.social &co show these diffs arise from mutational target size & heritability per site; when controlled for, all tested traits have similar architectures @plosbiology.org 🧪 plos.io/47mZXqT
Heritability and target size underlie differences between trait architectures: examples for three traits. Top: Height (blue) and platelet crit (red) have the same heritability per site h2/L, but height has a much higher mutational target size L. This results in many more hits for height (1533) than for platelet crit (648) (2 left panels). However, the marginal distributions of effect sizes, MAFs, and z-scores of hits are nearly identical for the two traits (3 right panels). Middle: Height (blue) and FEV1 (gold) differ in h2/L, but have similar L. Consequently, the joint distribution of z-scores and MAFs of their hits are markedly different (2 left panels), as are the marginal distributions of hit effect sizes, MAFs and z-scores (right). Bottom: After scaling by their respective , and imposing the more stringent scaled significance threshold (corresponding to FEV1) for both traits, the joint distribution of z-scores and MAFs of their hits (2 left panels) and the corresponding marginal distributions (3 right panels) are highly similar.
October 13, 2025 at 6:20 PM
Reposted by Jun Ishigohoka
biorxiv-evobio.bsky.social
An empirical long-term competition among natural yeast isolates reveals that short-term fitness largely but not entirely predicts long-term outcomes https://www.biorxiv.org/content/10.1101/2025.10.09.681448v1
October 10, 2025 at 9:32 PM