Pinned
Inhibitory inputs from thalamus promote resilient spiking in tail of striatum
Neuroscience; Sensory neuroscience
www.cell.com
Latest from the lab: Laura Haetzel finds that excitatory transmission from auditory thalamus to tail of striatum is accompanied by a sparse inhibitory projection. This allows for state-dependent control of striatal output.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Jan Gründemann
Neurons that dampen electrical brain activity influence emotional memories more than expected.
DZNE's @sabinekrabbe.bsky.social and colleagues report in @nature.com Communications that these cells are key for how memories form - offering new clues to anxiety and PTSD.
👉 www.dzne.de/en/im-fokus/...
DZNE's @sabinekrabbe.bsky.social and colleagues report in @nature.com Communications that these cells are key for how memories form - offering new clues to anxiety and PTSD.
👉 www.dzne.de/en/im-fokus/...
November 28, 2025 at 10:23 AM
Neurons that dampen electrical brain activity influence emotional memories more than expected.
DZNE's @sabinekrabbe.bsky.social and colleagues report in @nature.com Communications that these cells are key for how memories form - offering new clues to anxiety and PTSD.
👉 www.dzne.de/en/im-fokus/...
DZNE's @sabinekrabbe.bsky.social and colleagues report in @nature.com Communications that these cells are key for how memories form - offering new clues to anxiety and PTSD.
👉 www.dzne.de/en/im-fokus/...
Detecting absence: A dedicated prediction-error signal emerging in the auditory thalamus
arxiv.org/pdf/2511.21605
arxiv.org/pdf/2511.21605
arxiv.org
November 27, 2025 at 8:27 AM
Detecting absence: A dedicated prediction-error signal emerging in the auditory thalamus
arxiv.org/pdf/2511.21605
arxiv.org/pdf/2511.21605
Reposted by Jan Gründemann
Join us for BonnBrain 2026!
The official deadline for abstract submission is December 15th, but we only have a few slots left and might be sold out before the deadline.
Apply quickly 👉 bonnbrain.de to be considered by our Scientific Committee!
The official deadline for abstract submission is December 15th, but we only have a few slots left and might be sold out before the deadline.
Apply quickly 👉 bonnbrain.de to be considered by our Scientific Committee!
November 26, 2025 at 3:25 PM
Join us for BonnBrain 2026!
The official deadline for abstract submission is December 15th, but we only have a few slots left and might be sold out before the deadline.
Apply quickly 👉 bonnbrain.de to be considered by our Scientific Committee!
The official deadline for abstract submission is December 15th, but we only have a few slots left and might be sold out before the deadline.
Apply quickly 👉 bonnbrain.de to be considered by our Scientific Committee!
Reposted by Jan Gründemann
Memory traces bias new learning for hippocampal generalization https://www.biorxiv.org/content/10.1101/2025.11.24.690297v1
November 26, 2025 at 7:15 AM
Memory traces bias new learning for hippocampal generalization https://www.biorxiv.org/content/10.1101/2025.11.24.690297v1
Reposted by Jan Gründemann
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1... 1/13 🧵
www.biorxiv.org/content/10.1... 1/13 🧵
Large-scale cellular-resolution read/write of activity enables discovery of cell types defined by complex circuit properties
The complexity of the mammalian brain’s vast population of interconnected neurons poses a formidable challenge to elucidate its underlying mechanisms of coordination and computation. A key step forwar...
www.biorxiv.org
November 13, 2025 at 12:24 AM
✨ New preprint ✨ What if we could watch AND control thousands of individual neurons in behaving mice—with stable access over months? 🧠⚡ Our work introduces transgenic all-optical tools that make this possible - and a resulting surprising discovery! 🔭💡
www.biorxiv.org/content/10.1... 1/13 🧵
www.biorxiv.org/content/10.1... 1/13 🧵
Reposted by Jan Gründemann
Out now: Favila, Capece Marsico et al. 2025, Nature Communications: Using longitudinal deep-brain imaging, we report that amygdala interneurons exhibit complex and heterogeneous plasticity during associative learning, at both the single-cell and population level.
👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...
Heterogeneous plasticity of amygdala interneurons in associative learning and extinction - Nature Communications
In this study, the authors uncover how diverse inhibitory interneurons in the amygdala flexibly contribute to fear and safety learning, revealing a key role for inhibition in emotional memory and adap...
www.nature.com
November 12, 2025 at 6:55 PM
Out now: Favila, Capece Marsico et al. 2025, Nature Communications: Using longitudinal deep-brain imaging, we report that amygdala interneurons exhibit complex and heterogeneous plasticity during associative learning, at both the single-cell and population level.
👉 www.nature.com/articles/s41...
👉 www.nature.com/articles/s41...
Reposted by Jan Gründemann
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
November 12, 2025 at 4:20 AM
Come to #Bonn next March and join the #BonnBrain Conference 2026! There’s still time left to register and submit your abstract:
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
🌍 https://bonnbrain.de/ @bonnbrainconf.bsky.social
⏰ March 23–25, 2026
📍 @dzne.science #DZNE
Reposted by Jan Gründemann
Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics. https://www.biorxiv.org/content/10.1101/2025.11.10.687664v1
November 11, 2025 at 4:15 PM
Learning-dependent cholinergic plasticity reconfigures cortical circuit dynamics. https://www.biorxiv.org/content/10.1101/2025.11.10.687664v1
Latest from the lab: Laura Haetzel finds that excitatory transmission from auditory thalamus to tail of striatum is accompanied by a sparse inhibitory projection. This allows for state-dependent control of striatal output.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Inhibitory inputs from thalamus promote resilient spiking in tail of striatum
Neuroscience; Sensory neuroscience
www.cell.com
November 11, 2025 at 3:04 PM
Latest from the lab: Laura Haetzel finds that excitatory transmission from auditory thalamus to tail of striatum is accompanied by a sparse inhibitory projection. This allows for state-dependent control of striatal output.
www.cell.com/iscience/ful...
www.cell.com/iscience/ful...
Reposted by Jan Gründemann
Next-generation enhancer AAVs for selective interspecies targeting of midbrain dopaminergic neurons https://www.biorxiv.org/content/10.1101/2025.11.06.687071v1
November 8, 2025 at 7:15 AM
Next-generation enhancer AAVs for selective interspecies targeting of midbrain dopaminergic neurons https://www.biorxiv.org/content/10.1101/2025.11.06.687071v1
Reposted by Jan Gründemann
Plateau potentials are instructive signals for behavioral timescale synaptic plasticity in the neocortex https://www.biorxiv.org/content/10.1101/2025.11.07.687250v1
November 8, 2025 at 8:15 AM
Plateau potentials are instructive signals for behavioral timescale synaptic plasticity in the neocortex https://www.biorxiv.org/content/10.1101/2025.11.07.687250v1
Reposted by Jan Gründemann
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
VTA dopamine neuron activity produces spatially organized value representations https://www.biorxiv.org/content/10.1101/2025.11.04.685995v1
November 7, 2025 at 8:46 PM
How do VTA DA neurons sculpt downstream representations to reinforce actions? VERY excited about our new preprint (by Alex Pan Vazquez & @czimmerman.bsky.social )
Reposted by Jan Gründemann
Sickness engrams modulate anticipatory immune responses https://www.biorxiv.org/content/10.1101/2025.11.03.686140v1
November 5, 2025 at 4:15 PM
Sickness engrams modulate anticipatory immune responses https://www.biorxiv.org/content/10.1101/2025.11.03.686140v1
Reposted by Jan Gründemann
Ephaptic-Axonal Interactions Shape Radial Biases DuringNeural Self-Organization https://www.biorxiv.org/content/10.1101/2025.11.03.686361v1
November 5, 2025 at 4:16 PM
Ephaptic-Axonal Interactions Shape Radial Biases DuringNeural Self-Organization https://www.biorxiv.org/content/10.1101/2025.11.03.686361v1
Reposted by Jan Gründemann
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
October 22, 2025 at 6:44 PM
Such a nice collection of brain-body interaction articles in the special issue of @currentbiology.bsky.social. Love the beautiful vagus nerve on the cover by Andreas Vesalius www.cell.com/current-biol...
Reposted by Jan Gründemann
We are hiring 🎉 Brandeis Neuroscience is looking for an Assistant Professor. The search is in the broad area of cellular/circuit neuroscience. It’s a fantastic place to do research and train students.If you’re interested, apply and reach out with any questions!
academicjobsonline.org/ajo/jobs/30961
academicjobsonline.org/ajo/jobs/30961
Brandeis University, Biology Department
Job #AJO30961, Assistant Professor in Biology and Neuroscience Program, Biology Department, Brandeis University, Waltham, Massachusetts, US
academicjobsonline.org
October 22, 2025 at 11:57 PM
We are hiring 🎉 Brandeis Neuroscience is looking for an Assistant Professor. The search is in the broad area of cellular/circuit neuroscience. It’s a fantastic place to do research and train students.If you’re interested, apply and reach out with any questions!
academicjobsonline.org/ajo/jobs/30961
academicjobsonline.org/ajo/jobs/30961
Reposted by Jan Gründemann
I am thrilled to share our latest work: we identified a population of central amygdala neurons that promote the earliest and perhaps most important social behavior: pup suckling!... We also developed new tools for pup neuroscience
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
October 21, 2025 at 10:18 AM
I am thrilled to share our latest work: we identified a population of central amygdala neurons that promote the earliest and perhaps most important social behavior: pup suckling!... We also developed new tools for pup neuroscience
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Work by @Jeff Moore now at USC, a collaboration with @Sam Pfaff lab
Reposted by Jan Gründemann
Selective coupling and decoupling coordinate distributed brain networks for precise action https://www.biorxiv.org/content/10.1101/2025.10.19.683309v1
October 20, 2025 at 6:15 PM
Selective coupling and decoupling coordinate distributed brain networks for precise action https://www.biorxiv.org/content/10.1101/2025.10.19.683309v1
Reposted by Jan Gründemann
Registration open: eveeno.com/applicationb...
Under the theme “From Genes to Circuits and Behavior”, top neuroscientists - incl. Cori Bargmann, @edvardmoser.bsky.social, Rosa Paolicelli, Maude Baldwin & Zachary Knight - will meet at to explore how neural circuits drive behavior.
Under the theme “From Genes to Circuits and Behavior”, top neuroscientists - incl. Cori Bargmann, @edvardmoser.bsky.social, Rosa Paolicelli, Maude Baldwin & Zachary Knight - will meet at to explore how neural circuits drive behavior.
October 20, 2025 at 12:53 PM
Registration open: eveeno.com/applicationb...
Under the theme “From Genes to Circuits and Behavior”, top neuroscientists - incl. Cori Bargmann, @edvardmoser.bsky.social, Rosa Paolicelli, Maude Baldwin & Zachary Knight - will meet at to explore how neural circuits drive behavior.
Under the theme “From Genes to Circuits and Behavior”, top neuroscientists - incl. Cori Bargmann, @edvardmoser.bsky.social, Rosa Paolicelli, Maude Baldwin & Zachary Knight - will meet at to explore how neural circuits drive behavior.
Reposted by Jan Gründemann
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
October 15, 2025 at 4:11 PM
Just out in Nature! “The astrocytic ensemble acts as a multiday trace to stabilize memory.” We identified astrocytic ensembles that link experiences across days to stabilize memory nature.com/articles/s41.... New astrocyte tools are openly available at Addgene: addgene.org/Jun_Nagai/. 1/8
Reposted by Jan Gründemann
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
October 16, 2025 at 6:04 PM
I am excited to share my PhD work on head-direction cells recorded in the wild, now published in @science.org, where we recorded neurons in bats flying outdoors on an island.
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
doi.org/10.1126/sci...
With @ray-neuro.bsky.social, Shir Maimon, Liora Las, Nachum Ulanovsky and many others
Reposted by Jan Gründemann
Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing interneurons of the basolateral amygdala https://www.biorxiv.org/content/10.1101/2025.10.07.680627v1
October 7, 2025 at 9:17 PM
Impact of serotonin transporter deficiency on parvalbumin- and neuropeptide Y-producing interneurons of the basolateral amygdala https://www.biorxiv.org/content/10.1101/2025.10.07.680627v1
Reposted by Jan Gründemann
👀“experience of a punished outcome generates a BLA representation that is selectively replayed when animals subsequently abort choice of the large/risky reward option.”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
Risk reshapes amygdala representation of choice https://www.biorxiv.org/content/10.1101/2025.10.06.680813v1
October 8, 2025 at 12:14 AM
👀“experience of a punished outcome generates a BLA representation that is selectively replayed when animals subsequently abort choice of the large/risky reward option.”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
⚡️“… risk leads to the incorporation of newly encoding BLA neurons into the pre-choice representation”
Reposted by Jan Gründemann
🔬 Join us for the next iBehave Seminar Series 2025 lecture with Prof. Dr. Mark Schnitzer @Stanford on Oct 9, 11:00 DZNE Bonn. Host: @jangrundemann.bsky.social
Title: Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics
📧 Zoom info: [email protected]
Title: Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics
📧 Zoom info: [email protected]
October 6, 2025 at 3:55 PM
🔬 Join us for the next iBehave Seminar Series 2025 lecture with Prof. Dr. Mark Schnitzer @Stanford on Oct 9, 11:00 DZNE Bonn. Host: @jangrundemann.bsky.social
Title: Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics
📧 Zoom info: [email protected]
Title: Cell-type specific voltage imaging of neural spiking, oscillations, waves, and memory dynamics
📧 Zoom info: [email protected]
Sensory origin of visually evoked activity in auditory cortex
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Sensory origin of visually evoked activity in auditory cortex
Sound-evoked face movements in mice largely account for sound-driven activity in visual
cortex. Yet visual stimuli rarely trigger face movements, and such movements fail
to explain visually evoked res...
www.cell.com
October 5, 2025 at 10:06 AM
Sensory origin of visually evoked activity in auditory cortex
www.cell.com/cell-reports...
www.cell.com/cell-reports...