UPenn Institute of Structural Biology
@isbupenn.bsky.social
Reposted by UPenn Institute of Structural Biology
Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...
November 17, 2025 at 2:23 PM
Visualization of lysosomal membrane proteins by cryo electron tomography ft. @bridget_mcveigh, José De Jesús-Pérez, @moiseenkovabell (@PennSysPharmATT), Prerana Gogoi, @MageswaranKumar & Elaine Mihelc (@isbupenn.bsky.social) @natcomms.nature.com www.nature.com/articles/s41...
Reposted by UPenn Institute of Structural Biology
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
November 5, 2025 at 4:23 PM
Excited to share our latest @nature.com: How does naloxone (Narcan) stop an opioid overdose? We determined the first GDP-bound μ-opioid receptor–G protein structures and found naloxone traps a novel "latent” state, preventing GDP release and G protein activation.💊🧪 🧵👇 www.nature.com/articles/s41...
We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award.
@yiweichang.bsky.social
@yiweichang.bsky.social
October 24, 2025 at 1:34 PM
We’re proud to celebrate our institute associate director, Dr. Yi-Wei Chang, for being named the 2025 recipient of the Michael S. Brown New Investigator Research Award.
@yiweichang.bsky.social
@yiweichang.bsky.social
Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Visualization of lysosomal membrane proteins by cryo electron tomography - Nature Communications
Lysosomes are vital for cellular health and linked to many diseases. Here, authors use cryo-ET to image intact lysosomes and resolve lysosomal protein structures, providing a platform to advance the s...
www.nature.com
October 17, 2025 at 6:43 PM
Congrats Bridget McVeigh, José De Jesús-Pérez, Elaine Mihelc & Vera Moiseenkova-Bell on your first cryoET publication "Visualization of lysosomal membrane proteins by cryo electron tomography" #cryoET #lysosomes #TRPML1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by UPenn Institute of Structural Biology
Thrilled to share that I’ll be joining the Perelman School of Medicine at the University of Pennsylvania! Our lab will be relocating to the Department of Pharmacology in Jan ’26. We’re hiring at all levels—reach out if you’re interested! @isbupenn.bsky.social @pennmedicine.bsky.social
September 28, 2025 at 9:32 PM
Thrilled to share that I’ll be joining the Perelman School of Medicine at the University of Pennsylvania! Our lab will be relocating to the Department of Pharmacology in Jan ’26. We’re hiring at all levels—reach out if you’re interested! @isbupenn.bsky.social @pennmedicine.bsky.social
Reposted by UPenn Institute of Structural Biology
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
September 23, 2025 at 10:42 AM
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
www.nexperion.net/semcm2026
Reposted by UPenn Institute of Structural Biology
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
May 15, 2025 at 7:51 PM
...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
Reposted by UPenn Institute of Structural Biology
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 7:51 PM
Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...
Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis
Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...
www.science.org
May 15, 2025 at 6:46 PM
Congratulations to Drs. Lynch, Burslem, Marmorstein, Yi-Wei, and the entire research team on the publication of your latest research article in the newest issue of Science magazine! | Science www.science.org/doi/10.1126/...
Reposted by UPenn Institute of Structural Biology
Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn
May 8, 2025 at 2:21 PM
Join the Institute of Structural Biology on 5/21 for the 4th Structural Biology Symposium! Learn more & register➡️ isb.med.upenn.edu/4th-structur... @BB_UPenn
🔬 The 4th Structural Biology Symposium is almost here!
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
May 2, 2025 at 6:47 PM
🔬 The 4th Structural Biology Symposium is almost here!
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Don’t miss out—there’s still time to register.
bit.ly/4iM5QAm
Reposted by UPenn Institute of Structural Biology
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
May 1, 2025 at 6:17 PM
Excited to see this out in @science.org today!! www.science.org/doi/10.1126/...
Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...
Mechanism of actin filament severing and capping by gelsolin - Nature Structural & Molecular Biology
The authors use cryo-electron microscopy to reveal two structural states of Ca2+-activated gelsolin bound to the actin filament, illuminating the mechanisms of filament severing and barbed end capping...
www.nature.com
April 24, 2025 at 4:24 PM
Congratulations to Roberto Dominguez and his lab on their latest Nature publication: "Mechanism of actin filament severing and capping by gelsolin"! 🧬 An exciting contribution to our understanding of cytoskeletal dynamics.📖 Read the full article here: www.nature.com/articles/s41...
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
March 17, 2025 at 6:21 PM
Registration is now open for the 4th Structural Biology Symposium.
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Poster abstract submission is due on 4/15/2025. isb.med.upenn.edu/4th-structur...
🧬@Structuralbiology
Reposted by UPenn Institute of Structural Biology
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
March 7, 2025 at 11:46 PM
Emily Whitehead and her father on CNN with Jake Tapper speaking to the value of science. She is alive thanks to CAR T therapy developed at Penn and CHOP.
Reposted by UPenn Institute of Structural Biology
Pharmacology 💊 women in STEM 👩🏻🔬 showed up & out for scientific funding! 🧬
#standupforscience2025
#standupforsciencephilly
#standupforscience2025
#standupforsciencephilly
March 7, 2025 at 7:18 PM
Pharmacology 💊 women in STEM 👩🏻🔬 showed up & out for scientific funding! 🧬
#standupforscience2025
#standupforsciencephilly
#standupforscience2025
#standupforsciencephilly
Reposted by UPenn Institute of Structural Biology
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
February 26, 2025 at 1:35 AM
Philadelphia Stand Up For Science! #standupforscience2025
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Friday, March 7 · 11am - 1pm
Philadelphia City Hall
standupforscience2025.org
Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase"
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
Snapshots of acyl carrier protein shuttling in human fatty acid synthase - Nature
Using cryo-electron microscopy, the structures of mammalian fatty acid synthase reveal how the acyl carrier protein dynamically shuttles intermediates between selected active sites.
www.nature.com
February 21, 2025 at 6:10 PM
Congrats Kollin Schultz & Ronen Marmorstein Lab on your Nature publication: "Snapshots of acyl carrier protein shuttling in human fatty acid synthase"
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
www.nature.com/articles/s41...
#cryoEM #StructuralBiology
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Structural insights into TRPV2 modulation by probenecid
Nature Structural & Molecular Biology - The authors reveal that probenecid, an FDA-approved drug, uniquely modulates TRPV2 through an intracellular pocket. Probenecid drives the channel into an...
www.nature.com
February 19, 2025 at 11:02 PM
Congrats Julia Rocereta & Moiseenkova-Bell Lab on your Nature Structural & Molecular Biology publication: "Structural insights into TRPV2 modulation by probenecid"
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
#cryoEM #TRPV2 #TRPchannels
www.nature.com/articles/s41...
Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com
January 23, 2025 at 7:59 PM
Thrilled to share our work with the Ben Black Lab, led by co-mentored star MD/PhD student Katie Kixmoeller @pennmedicine.bsky.social, now in @cellcellpress.bsky.social ! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
authors.elsevier.com/c/1kUW9L7PXq...
authors.elsevier.com/c/1kUW9L7PXq...