The Interactive Fly
@interactivefly.bsky.social
The Interactive Fly (https://www.sdbonline.org/sites/fly/aimain/1aahome.htm) is a cyberspace guide to Drosophila Development. Special sites describe Drosophila as a model of human diseases, stress response, neural circuits, evolution, and behavior
Villalobos-Cantor, S., Arreola-Bustos, A., Martin, I. (2025). Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila. Genetics, 230(3) academic.oup.com/genetics/art...
Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila
Paraquat is linked to increased PD risk and to dopaminergic neurodegeneration in animal studies. Gene-environment interactions likely influence whether an
academic.oup.com
January 15, 2026 at 7:26 PM
Villalobos-Cantor, S., Arreola-Bustos, A., Martin, I. (2025). Genome-wide analysis reveals genes mediating resistance to paraquat neurodegeneration in Drosophila. Genetics, 230(3) academic.oup.com/genetics/art...
Adebambo, T. H., Medina-Flores, F., Zhang, S., Lerit, D. A. (2025). Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model. G3 (Bethesda), 15(5) academic.oup.com/g3journal/ar...
Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model
Abstract. Despite established exposure limits, arsenic remains the most significant environmental risk factor detrimental to human health and is associated
academic.oup.com
January 15, 2026 at 7:25 PM
Adebambo, T. H., Medina-Flores, F., Zhang, S., Lerit, D. A. (2025). Arsenic impairs Drosophila neural stem cell mitotic progression and sleep behavior in a tauopathy model. G3 (Bethesda), 15(5) academic.oup.com/g3journal/ar...
Bhatnagar, A., Thomas, C. M., Nge, G. G., Zaya, A., Dasari, R., Chongtham, N., Manandhar, B., Kortagere, S., Elefant, F. (2025). Tip60 HAT activators as therapeutic modulators for Alzheimer's disease. Nat Commun, 16(1):3347 www.nature.com/articles/s41...
Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease - Nature Communications
In this work, authors test Tip60 HAT activation as a therapeutic strategy for selectively restoring cognition-associated histone acetylation depleted in AD by developing compounds that bind to and enh...
www.nature.com
January 15, 2026 at 7:23 PM
Bhatnagar, A., Thomas, C. M., Nge, G. G., Zaya, A., Dasari, R., Chongtham, N., Manandhar, B., Kortagere, S., Elefant, F. (2025). Tip60 HAT activators as therapeutic modulators for Alzheimer's disease. Nat Commun, 16(1):3347 www.nature.com/articles/s41...
Yan, J., Feng, C., Zhang, H., Luo, T., Chen, H., Chen, H. (2025). Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila. Front Cell Dev Biol, 13:1576258 www.frontiersin.org/journals/cel...
Frontiers | Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila
IntroductionIntestinal stem cells (ISCs) possess the ability to self-renew and differentiate, which is essential for maintaining intestinal tissue homeostasi...
www.frontiersin.org
January 15, 2026 at 7:16 PM
Yan, J., Feng, C., Zhang, H., Luo, T., Chen, H., Chen, H. (2025). Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila. Front Cell Dev Biol, 13:1576258 www.frontiersin.org/journals/cel...
Philyaw, T. J., Titos, I., Cummins-Beebee, P. N., Rodan, A. R., Rothenfluh, A. (2025). Bitter Sensing Protects Drosophila from Developing Experience-Dependent Cocaine Consumption Preference. J Neurosci, 45(27) www.jneurosci.org/content/45/2...
Bitter Sensing Protects Drosophila from Developing Experience-Dependent Cocaine Consumption Preference
Cocaine is an addictive psychostimulant, and the risk of developing cocaine use disorder (CUD) is highly heritable. Little is known about the specific genes and mechanisms that lead to the development...
www.jneurosci.org
January 14, 2026 at 10:13 PM
Philyaw, T. J., Titos, I., Cummins-Beebee, P. N., Rodan, A. R., Rothenfluh, A. (2025). Bitter Sensing Protects Drosophila from Developing Experience-Dependent Cocaine Consumption Preference. J Neurosci, 45(27) www.jneurosci.org/content/45/2...
Macartney, E. L., Burke, S., Pottier, P., ...., Neely, G. G., Drobniak, S. M., Nakagawa, S. (2025). Sex-Specific Effects of Social Environment on Behaviour and Their Correlations in Drosophila melanogaster. Ecol Evol, 15(4):e71261 onlinelibrary.wiley.com/doi/10.1002/...
January 14, 2026 at 10:11 PM
Macartney, E. L., Burke, S., Pottier, P., ...., Neely, G. G., Drobniak, S. M., Nakagawa, S. (2025). Sex-Specific Effects of Social Environment on Behaviour and Their Correlations in Drosophila melanogaster. Ecol Evol, 15(4):e71261 onlinelibrary.wiley.com/doi/10.1002/...
Wu, Z., Wu, X., Wang, Z., Ye, X.,....,Drezen, J. M., Strand, M. R., Chen, X. (2025). A symbiotic gene stimulates aggressive behavior favoring the survi val of parasitized caterpillars. Proc Natl Acad Sci U S A, 122(18):e2422935122 www.pnas.org/doi/10.1073/...
January 14, 2026 at 10:09 PM
Wu, Z., Wu, X., Wang, Z., Ye, X.,....,Drezen, J. M., Strand, M. R., Chen, X. (2025). A symbiotic gene stimulates aggressive behavior favoring the survi val of parasitized caterpillars. Proc Natl Acad Sci U S A, 122(18):e2422935122 www.pnas.org/doi/10.1073/...
Vaxenburg, R., Siwanowicz, I., Merel, J., ...., Reiser, M. B., Botvinick, M. M., Branson, K. M., Tassa, Y., Turaga, S. C. (2025). Whole-body physics simulation of fruit fly locomotion. Nature, www.nature.com/articles/s41...
January 14, 2026 at 10:08 PM
Vaxenburg, R., Siwanowicz, I., Merel, J., ...., Reiser, M. B., Botvinick, M. M., Branson, K. M., Tassa, Y., Turaga, S. C. (2025). Whole-body physics simulation of fruit fly locomotion. Nature, www.nature.com/articles/s41...
Yoshino, J., Mali, S. S., Williams, C. R., ..., Ishii, K., Emoto, K., Bautista, D. M., Parrish, J. Z. (2025). Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Elife, 13https://elifesciences.org/articles/95379
January 14, 2026 at 10:06 PM
Yoshino, J., Mali, S. S., Williams, C. R., ..., Ishii, K., Emoto, K., Bautista, D. M., Parrish, J. Z. (2025). Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs. Elife, 13https://elifesciences.org/articles/95379
Wang, C., Shen, J. (2025). From metabolism to lifespan trade-offs: polyethylene microplastics induce circadian disruption and sex-specific aging in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol, 295:110214 www.sciencedirect.com/science/arti...
From metabolism to lifespan trade-offs: polyethylene microplastics induce circadian disruption and sex-specific aging in Drosophila melanogaster
Microplastics (MPs), particularly polyethylene microplastics (PE-MPs), are increasingly recognized as contaminants in both aquatic and terrestrial env…
www.sciencedirect.com
January 12, 2026 at 6:39 PM
Wang, C., Shen, J. (2025). From metabolism to lifespan trade-offs: polyethylene microplastics induce circadian disruption and sex-specific aging in Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol, 295:110214 www.sciencedirect.com/science/arti...
Rossano, A., Zhang, L., ..., Mount, D., Romero, M. F. (2025). Ex vivo quantification of intracellular pH in Drosophila Malpighian tubule reveals basolateral HCO(3) (-)/oxalate exchange through a novel oxalate transporter "Neat". Front Physiol, 16:1468451 www.frontiersin.org/journals/phy...
Frontiers | Ex vivo quantification of intracellular pH in Drosophila Malpighian tubule reveals basolateral HCO3−/oxalate exchange through a novel oxalate transporter “Neat”
IntroductionNephrolithiasis is a painful and costly healthcare complication. The most common kidney stones are composed of calcium oxalate and thus renal han...
www.frontiersin.org
January 12, 2026 at 6:38 PM
Rossano, A., Zhang, L., ..., Mount, D., Romero, M. F. (2025). Ex vivo quantification of intracellular pH in Drosophila Malpighian tubule reveals basolateral HCO(3) (-)/oxalate exchange through a novel oxalate transporter "Neat". Front Physiol, 16:1468451 www.frontiersin.org/journals/phy...
Rai, M., Li, H., Policastro, R. A., Pepin, R., Zentner, G. E., Nemkov, T., D'Alessandro, A., Tennessen, J. M. (2025). Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3. PLoS Genet, 21(5):e1011690 journals.plos.org/plosgenetics...
Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3
Author summary Animal development requires precise coordination between growth, metabolism, and nutrition. When animals are raised under ideal conditions, dietary nutrients support optimal growth by d...
journals.plos.org
January 12, 2026 at 6:36 PM
Rai, M., Li, H., Policastro, R. A., Pepin, R., Zentner, G. E., Nemkov, T., D'Alessandro, A., Tennessen, J. M. (2025). Glycolytic disruption restricts Drosophila melanogaster larval growth via the cytokine Upd3. PLoS Genet, 21(5):e1011690 journals.plos.org/plosgenetics...
Van De Poll, M. N., van Swinderen, B. (2025). Long-term multichannel recordings in Drosophila flies reveal altered predictive processing during sleep compared with wake. J Exp Biol, 228(11) journals.biologists.com/jeb/article/...
January 12, 2026 at 6:35 PM
Van De Poll, M. N., van Swinderen, B. (2025). Long-term multichannel recordings in Drosophila flies reveal altered predictive processing during sleep compared with wake. J Exp Biol, 228(11) journals.biologists.com/jeb/article/...
Yu, G., Yang, Q., Wu, Q. (2025). Rapamycin Alters the Feeding Preference for Amino Acids and Sugar in Female Drosophila. J Gerontol A Biol Sci Med Sci, 80(7) academic.oup.com/biomedgeront...
Rapamycin Alters the Feeding Preference for Amino Acids and Sugar in Female Drosophila
Abstract. Rapamycin has demonstrated significant lifespan-extending effects across a variety of model organisms, positioning it as one of the most promisin
academic.oup.com
January 12, 2026 at 6:34 PM
Yu, G., Yang, Q., Wu, Q. (2025). Rapamycin Alters the Feeding Preference for Amino Acids and Sugar in Female Drosophila. J Gerontol A Biol Sci Med Sci, 80(7) academic.oup.com/biomedgeront...
Subaric, D., Rastija, V., Karnas Babi , M., Agic, D., Majic, I. (2025). Structural Features of Coumarin-1,2,4-Triazole Hybrids Important for Insecticidal Effects Against Drosophila melanogaster and Orius laevigatus (Fieber). Molecules, 30(8 www.mdpi.com/1420-3049/30...
January 12, 2026 at 6:32 PM
Subaric, D., Rastija, V., Karnas Babi , M., Agic, D., Majic, I. (2025). Structural Features of Coumarin-1,2,4-Triazole Hybrids Important for Insecticidal Effects Against Drosophila melanogaster and Orius laevigatus (Fieber). Molecules, 30(8 www.mdpi.com/1420-3049/30...
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Parkin mediates the mitochondrial dysfunction through mRpL18
Loss of function of parkin leads to mitochondrial dysfunction, which is closely related
to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma
is that impaired Parkin caus...
www.jbc.org
January 8, 2026 at 9:14 PM
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Parkin mediates the mitochondrial dysfunction through mRpL18
Loss of function of parkin leads to mitochondrial dysfunction, which is closely related
to Parkinson's disease. However, the in vivo mechanism is far from clear. One dogma
is that impaired Parkin caus...
www.jbc.org
January 8, 2026 at 9:12 PM
Ti, X., Zuo, H., Zhao, G., Li, Y., Du, M., Xu, L., Li, S., Shan, Z., Gao, Y., Gan, G., Wang, Y., Zhang, Q. (2025). Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem, 301(6):110208 www.jbc.org/article/S002...
Scudese, E., Marshall, A. G., Vue, Z., Exil, V., ..., Sharma, V., Mobley, B. C., Katti, P., Hinton, A. (2025). 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes. Aging Cell:e70054 onlinelibrary.wiley.com/doi/10.1111/...
January 8, 2026 at 9:11 PM
Scudese, E., Marshall, A. G., Vue, Z., Exil, V., ..., Sharma, V., Mobley, B. C., Katti, P., Hinton, A. (2025). 3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes. Aging Cell:e70054 onlinelibrary.wiley.com/doi/10.1111/...
Tan, S. L., Neumann, D., Trim, P. J., ...., O'Keefe, L. V., Hemsley, K. M., Lau, A. A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Mol Genet Metab, 145(2):109112 www.sciencedirect.com/science/arti...
Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome
Mucopolysaccharidosis (MPS) types III A and C are inherited neurodegenerative disorders resulting from the lack of a specific enzyme involved in hepar…
www.sciencedirect.com
January 8, 2026 at 9:09 PM
Tan, S. L., Neumann, D., Trim, P. J., ...., O'Keefe, L. V., Hemsley, K. M., Lau, A. A. (2025). Substrate reduction using a glucosamine analogue in Drosophila melanogaster and mouse models of Sanfilippo syndrome. Mol Genet Metab, 145(2):109112 www.sciencedirect.com/science/arti...
Singh, K., Gupta, K., Shukla, S., Kumari, A. P., Kumar, A. (2025). Repurposing Oseltamivir Against CAG Repeat Mediated Toxicity in Huntington's Disease and Spinocerebellar Ataxia Using Cellular and Drosophila Model. ACS Omega, 10(15):14980-14993 pmc.ncbi.nlm.nih.gov/articles/PMC...
January 8, 2026 at 9:08 PM
Singh, K., Gupta, K., Shukla, S., Kumari, A. P., Kumar, A. (2025). Repurposing Oseltamivir Against CAG Repeat Mediated Toxicity in Huntington's Disease and Spinocerebellar Ataxia Using Cellular and Drosophila Model. ACS Omega, 10(15):14980-14993 pmc.ncbi.nlm.nih.gov/articles/PMC...
Song, H., Kim, S., Han, J. E., Kang, K. H., Koh, H. (2025). PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models. Biomedicines, 13(4) www.mdpi.com/2227-9059/13...
January 8, 2026 at 9:07 PM
Song, H., Kim, S., Han, J. E., Kang, K. H., Koh, H. (2025). PDH Inhibition in Drosophila Ameliorates Sensory Dysfunction Induced by Vincristine Treatment in the Chemotherapy-Induced Peripheral Neuropathy Models. Biomedicines, 13(4) www.mdpi.com/2227-9059/13...
Serebryany-Piavsky, V., Egulsky, L., Manoim-Wolkovitz, J. E., Anis, S., Hassin-Baer, S., Parnas, M., Horowitz, M. (2025). The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. Hum Mol Genet, 34(14):1184-1203 academic.oup.com/hmg/article/...
The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease
Abstract. Parkinson disease (PD) is the second most common neurodegenerative disease. While most cases are sporadic, in ~ 5%–10% of PD patients the disease
academic.oup.com
January 8, 2026 at 9:05 PM
Serebryany-Piavsky, V., Egulsky, L., Manoim-Wolkovitz, J. E., Anis, S., Hassin-Baer, S., Parnas, M., Horowitz, M. (2025). The modifying effect of mutant LRRK2 on mutant GBA1-associated Parkinson disease. Hum Mol Genet, 34(14):1184-1203 academic.oup.com/hmg/article/...
Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
January 7, 2026 at 7:17 PM
Lee, U., Li, C., Langer, C. B., Svetec, N., Zhao, L. (2025). Comparative single-cell analysis of transcriptional bursting reveals the role of genome organization in de novo transcript origination. Proc Natl Acad Sci U S A, 122(18):e2425618122 www.pnas.org/doi/10.1073/...
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins | American Journal of Physiology-Cell Physiology ...
Prickle 1, an ortholog found in Drosophila, was localized at the Sertoli cell-spermatid interface consistent with its role of supporting the Vangl2 planar cell polarity (PCP), which is an integral mem...
journals.physiology.org
January 7, 2026 at 7:14 PM
Wang, L., Bu, T., Gao, S., ...., Cheng, C., Sun, F. (2025). PCP protein Prickle 1 regulates Sertoli cell and testis function via cytoskeletal organization through the recruitment of multiple regulatory proteins. Am J Physiol Cell Phys., 328(6):C2032-c2056 journals.physiology.org/doi/full/10....
Ku, H. Y., Bilder, D. (2025). Basement membrane patterning by spatial deployment of a secretion-regulating protease. Proc Natl Acad Sci U S A, 122(20):e2412161122 www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
January 7, 2026 at 7:10 PM
Ku, H. Y., Bilder, D. (2025). Basement membrane patterning by spatial deployment of a secretion-regulating protease. Proc Natl Acad Sci U S A, 122(20):e2412161122 www.pnas.org/doi/10.1073/...