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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 2d

“Understanding the role of the Hippo signalling pathway in ependymoma tumour biology” is available in the first volume of the new #NeuroOncology #Pediatrics:

bit.ly/471UhkK

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 4d

Read the systematic review and meta-analysis which evaluates the effect of #GammaKnife #radiosurgery dose-rate on managing intracranial targets, encompassing an assessment of its association with radiation-related toxicity and adverse effects.

bit.ly/3Kt8UWJ

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 6d

A new article in @BrainTumourOrg highlights the findings from the Lancet Oncology paper ‘Analysis of TERT association with clinical outcome in #meningiomas: a multi-institutional cohort study’

bit.ly/46CpXhN

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 9d

Meet #ICOM member Clara Lopez, a biologist and PhD student driven by a passion for #CancerResearch. From Spain to New Zealand’s Gillies McIndoe Research Institute, she explores #meningiomas to unlock new drug treatments. Outside the lab, she loves playing frisbee with friends.

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 13d

This new study highlights the role of #NOTCH3 in mediating fatty acid oxidation in #meningiomas, and a potential mechanism for increased malignant potential of NOTCH3 + meningiomas.

bit.ly/42dfxTc

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 16d

What are the correlations between surface marker patterns in #meningiomas, prognosis, and location?

Read more about this recent research in the Journal of Clinical Neuroscience: bit.ly/4mAcTOD

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 18d

Findings:
🧠Response #biomarkers are needed for successful #NeuroOncology #immunotherapy trials
🧠Multiple molecular, cellular & radiologic approaches have shown promise
🧠Validation is needed before these biomarkers can be used to inform clinical trials

bit.ly/3Iyxox6

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 20d

This study provides regional insight into the molecular landscape of #meningiomas. It found while routine molecular profiling adds value to classification and prognostication, broader implementation may be limited by cost and panel coverage constraints.

bit.ly/3Iuq71e

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 23d

Read the new review in #NeuroOncology Advances focusing on recent advances and highlighting the #epidemiological, #pathological, #molecular/genetic, and clinical characteristics of #SpinalMeningiomas.

academic.oup.com/noa/article/...

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · 27d

In our new special edition, #Immunotherapy for #BrainTumors, Alexander P Landry, Gavin P Dunn, and Michael Lim provide an overview of the current state of neuro-oncologic immunotherapy as covered in the supplement.

academic.oup.com/noa/article/...

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Sep 12

This new review and analysis reveals that #meningiomas can significantly impact #CognitiveFunction, affecting various domains such as memory, executive function, attention, and language. Most of these domains seem to improve postoperatively.

bit.ly/4nn0RJb

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Sep 10

The new supplement on #Immunotherapy for #BrainTumors is now out in #NeuroOncologyAdvances, edited by Alex Landry, Michael Lim, and Gavin Dunn.

Thank you to the authors, peer reviewers, manuscript editors, and Editor-In-Chief @gelarehzadeh.bsky.social.

bit.ly/460ahEQ

Reposted by International Consortium on Meningiomas (ICOM)

OncLive @onclive.bsky.social · Sep 8

New Genetic Biomarker Flags Aggressive Brain Tumors @gelarehzadeh.bsky.social @mayocliniccancer.bsky.social @thelancetoncol.bsky.social #btsm #oncology
www.onclive.com/view/new-gen...

New Genetic Biomarker Flags Aggressive Brain Tumors

A new study suggests that if a tumor shows activity in the TERT gene, it tends to recur more quickly, even if it looks low-grade under the microscope.

www.onclive.com

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Sep 8

Dr Linda Bi, Dr Ruchit Patel, Dr Chloe Gui, Dr Farshad Nassiri, and Dr Matija Snuderl joined the #Lancet #Oncology “In Conversation with” #podcast to discuss their new papers on #TERTexpression and TERT promoter mutations in #meningiomas.

Listen now: www.thelancet.com/multimedia/p...

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Sep 3

#ICOM & some of our members just published an article investigating the prevalence & prognostic association of #TERT expression in #meningiomas, with implications for diagnosis & treatment: bit.ly/4g8L0LZ

@gelarehzadeh.bsky.social @justinzwang.bsky.social @felixehretmd.bsky.social @syip.bsky.social

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Sep 1

What is the potential for #MolecularProfiling to refine surgical and #radiotherapy decision-making in #meningioma?

Read the recent study in @NatureMedicine:

go.nature.com/3GygVIj

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 29

#BAP1-altered #meningiomas represent a distinct and aggressive CNS tumor subtype associated with PRC dysregulation and recurrent 3p chromosome loss. These findings support the designation “meningioma, BAP1-altered.”

Read full article in #NeuroOncology:

bit.ly/3YWa1CN

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 27

Do you have clinical and research interests in #meningiomas, and want to find out more about becoming an #ICOM member?

Contact us today: bit.ly/3HyhPoD

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 25

Collision tumors are rare. Among these, the metastasis of #melanoma into an intracranial #meningioma is particularly uncommon, with only 4 previously reported cases. This #CaseReport present the 5th documented case.

bit.ly/3HOyZyr

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 22

This new study in Scientific Reports evaluates intracranial pressure in NF2-associated #meningiomas using perioperative #OpticNerveSheath diameter measurements.

Read it now: go.nature.com/4oJWSI7

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 20

Have you read the new edition of our #ICOM newsletter?

In it, you can read about the latest #meningioma-related events and articles from our members.

adobe.ly/45yJe1R

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International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 18

Read this recent study in the JNS exploring potential correlations between the recurrence rate of #SphenoOrbital #meningiomas and the extent of resection of both the bony tumor portion and soft tumor portion.

bit.ly/4mkxNBL

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 15

Read the new article “Postoperative #radiotherapy in subtotally resected recurrent WHO grade 1 #meningiomas with intermediate-/high-risk molecular profiles” in #NeuroOncology by authors including our #ICOM members:

bit.ly/40wecpJ

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 13

The new edition of our #ICOM newsletter is now out!

Read about the latest #meningioma-related events and articles from our members: adobe.ly/45yJe1R

International Consortium on Meningiomas (ICOM) @icomeningioma.bsky.social · Aug 11

A new study, showing that unidimensional tumor measurements and tumor volume assessments show a stronger association with overall survival than bidimensional measurements in recurrent non-benign #meningiomas, is now out in #NeuroOncology Advances:

bit.ly/4l0xrPx

Prognostic value of 1D, 2D and volumetric tumor size increases in recurrent WHO grade 2 and 3 meningiomas: radiological post-hoc analysis of the EORTC-BTG-1320 trial

Julia Furtner, Luzia Berchtold, Emilie Le Rhun, Antonio Silvani, Roberta Rudà, Giuseppe Lombardi, Juan Manuel Sepúlveda-Sánchez, Petter Brandal, Martin Bendszus, Vassilis Golfinopoulos, Thierry Gorlia, Felix Sahm, Wolfgang Wick, Giuseppe Minniti, Michael Weller, Franz König, Matthias Preusser