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hemehub.bsky.social
@hemehub.bsky.social
44 followers 71 following 160 posts
HemeHub (formerly BMFCases) | Supporting hematology by enhancing care, driving innovation, and advancing research & treatment strategies.

https://www.hemehub.org
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hemehub.bsky.social
Today's second question focuses on the genetic mechanism leading to low factor VIII levels and bleeding in female carriers of Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #ClinicalTrials
November 29, 2025 at 12:38 AM
hemehub.bsky.social
Today’s first question focuses on the genetic mechanism underlying unexpected severe bleeding in an infant with no maternal bleeding history.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #ClinicalTrials
November 29, 2025 at 12:37 AM
hemehub.bsky.social
Facts about Hemophilia A: Inhibitors and Immune Complications, and Future Directions

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social
November 29, 2025 at 12:37 AM
hemehub.bsky.social
The second question of the day!

See the answer and explanation on the next slide.

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @ash.edu.hematology.org
November 27, 2025 at 3:41 AM
hemehub.bsky.social
Today's first question!

See the answer and explanation on the next slide.

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 27, 2025 at 3:40 AM
hemehub.bsky.social
Facts about Hemophilia A: Rebalancing and RNA-Based Therapies

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 27, 2025 at 3:39 AM
hemehub.bsky.social
The second question of the day focuses on understanding complications in patients receiving fitusiran prophylaxis.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
November 25, 2025 at 3:09 AM
hemehub.bsky.social
Today’s first question focuses on why a child on regular recombinant Factor VIII prophylaxis may still experience several bleeding episodes each year.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab
November 25, 2025 at 3:09 AM
hemehub.bsky.social
Facts about Hemophilia A: Non-Factor (Substitution) Therapies

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 25, 2025 at 3:08 AM
hemehub.bsky.social
Today’s question focuses on the type of viral vector most commonly used in gene therapy trials for Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
November 21, 2025 at 10:28 PM
hemehub.bsky.social
Facts about Hemophilia A: Treatment — Factor Replacement Era

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @thjournal.bsky.social @htrstoday.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 21, 2025 at 10:28 PM
hemehub.bsky.social
Today’s question focuses on safe management of breakthrough bleeding in a patient receiving emicizumab prophylaxis.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials
November 20, 2025 at 8:37 PM
hemehub.bsky.social
Facts about Hemophilia A:

Additional information on diagnosis and screening

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @sfthemostase.bsky.social @thjournal.bsky.social
November 20, 2025 at 8:36 PM
hemehub.bsky.social
Today’s question focuses on the expected laboratory pattern in a child with Hemophilia A who presents with bleeding after missing a prophylactic infusion.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy
November 17, 2025 at 11:13 PM
hemehub.bsky.social
Facts about Hemophilia A: Diagnosis and Screening

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @thjournal.bsky.social @htrstoday.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 17, 2025 at 11:10 PM
hemehub.bsky.social
Today’s question focuses on hemostatic management before a dental procedure in a patient with mild Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy
November 16, 2025 at 12:25 AM
hemehub.bsky.social
Facts about Hemophilia A: Clinical Manifestations

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy @thjournal.bsky.social @athnnews.bsky.social @htrstoday.bsky.social @sfthemostase.bsky.social @ash.edu.hematology.org
November 16, 2025 at 12:24 AM
hemehub.bsky.social
Today’s question highlights the first diagnostic step in evaluating a newborn with suspected Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #InternalMedicine #ClinicalTrials #BloodDisorders
November 13, 2025 at 8:06 PM
hemehub.bsky.social
Facts about Hemophilia A: Clinical Manifestations

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social @athnnews.bsky.social
November 13, 2025 at 8:05 PM
hemehub.bsky.social
Today’s question highlights the cytokine responsible for joint damage in Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #Emicizumab #InternalMedicine #ClinicalTrials #BloodDisorders
November 12, 2025 at 2:08 AM
hemehub.bsky.social
Happening this Friday!

🔗Register now: hemehub.org/live-events

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #ClinicalTrials #BloodDisorders @jthjournal.bsky.social @isth.org @htrstoday.bsky.social @thjournal.bsky.social @sfthemostase.bsky.social
hemehub.bsky.social hemehub.bsky.social @hemehub.bsky.social · Oct 29
🩸Join us for a special session with Dr. Shannon Meeks to explore advances in hemophilia A research!

🔗Register now: hemehub.org/live-events

#HemophiliaA #Hemostasis #BloodDisorders #Hematology #ClinicalTrials @isth.org @thjournal.bsky.social @ash.edu.hematology.org @cuhemeonc.bsky.social
November 10, 2025 at 9:53 PM
hemehub.bsky.social
Today’s question focuses on bleed management in a young patient with severe Hemophilia A who has developed an inhibitor.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #ClinicalTrials #BloodDisorders
November 10, 2025 at 9:51 PM
hemehub.bsky.social
Facts about Hemophilia A: Molecular Genetics and Pathogenesis

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy @ash.edu.hematology.org @ash.hematology.org @htrstoday.bsky.social @thjournal.bsky.social @athnnews.bsky.social @isth.org @jthjournal.bsky.social
November 10, 2025 at 9:49 PM
hemehub.bsky.social
Today’s question highlights how to approach a new bleed and prolonged aPTT in a patient on prophylaxis for Hemophilia A.

See the answer and explanation on the next slide!

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation #GeneTherapy #ClinicalTrials #BloodDisorders
November 8, 2025 at 10:36 PM
hemehub.bsky.social
Facts about Hemophilia A: Molecular Genetics and Pathogenesis

Key genetic mutations in the factor 8 gene determine disease severity, with intron inversions linked to severe cases and missense mutations causing milder forms.

#Hemophilia #BleedingDisorders #Hematology #RareDiseases #Coagulation
November 8, 2025 at 10:35 PM