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Hematology Advisor @hematologyadvisor.bsky.social · 7h

Researchers developed an ethical framework for allocating gene therapy to patients with #SCD or #TDT. Reported in @bloodjournals.hematology.org.

https://bit.ly/47uPUPv

Researchers Develop Ethics-Based Framework for Allocating Gene Therapies to Patients With SCD or TDT

Researchers developed an ethical framework for allocating gene therapy to patients with SCD or TDT.

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Hematology Advisor @hematologyadvisor.bsky.social · 1d

CTC levels are an independent prognostic factor for patients with transplant-eligible, #NDMM who were treated with a standard-of-care quadruplet regimen. Published in @bloodjournals.hematology.org and @cancertherapyadv.bsky.social.

https://bit.ly/4oHqTYd

#multipleMyeloma

CTCs Show Promise as Prognostic Biomarker in Newly Diagnosed Multiple Myeloma

CTC levels may be prognostic in patients with transplant-eligible, newly diagnosed MM who were treated with a standard-of-care quadruplet regimen.

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Hematology Advisor @hematologyadvisor.bsky.social · 2d

Younger vs older women are more susceptible to changes to their #menstrual cycle after receiving the #COVID19vaccine. Published in @plosone.org and @infectiousdisease.bsky.social.

https://bit.ly/47xqnFt

Adolescent, Young Adult Menstrual Cycles Prolonged After COVID-19 Vaccination

Adolescents and young adults were more susceptible to changes in their menstrual cycle following COVID-19 vaccination compared with older women.

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Hematology Advisor @hematologyadvisor.bsky.social · 2d

A female patient in her 60s was diagnosed with systemic mastocytosis associated with #PCFCL. Published in @rarediseaseadvisor.bsky.social.

https://bit.ly/47O33Ew

#lymsm

Primary Cutaneous Follicle Center Lymphoma Associated With Systemic Mastocytosis - Oncology Nurse Advisor

This is likely the first case report on primary cutaneous follicle center lymphoma associated with bone marrow mastocytosis.

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Hematology Advisor @hematologyadvisor.bsky.social · 3d

An elderly man with no prior history of bleeding disorders experienced recurrent acute subdural hematoma following a mild head trauma and was diagnosed with mild congenital #hemophilia A. Published in @cureusmedical.bsky.social and @rarediseaseadvisor.bsky.social.

https://bit.ly/3JsRbyy

Acute Subdural Hematoma in Elderly Patient Diagnosed as Hemophilia

Undiagnosed bleeding disorders should be considered in elderly patients who present with unexplained postoperative hemorrhage.

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Hematology Advisor @hematologyadvisor.bsky.social · 4d

The combination of PTCy and Aba significantly reduced chronic #GVHD and improved GRFS compared with standard tacrolimus and methotrexate prophylaxis in patients undergoing allo-HSCT. Published in @bloodjournals.hematology.org.

https://bit.ly/43A8Zys

Posttransplant Cyclophosphamide Plus Abatacept Reduces Chronic GVHD After Allo-HSCT

PTCy and abatacept significantly reduced chronic GVHD and improved GRFS compared with standard tacrolimus and methotrexate prophylaxis in patients undergoing allo-HSCT.

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Hematology Advisor @hematologyadvisor.bsky.social · 5d

Among a heavily pretreated, older adult population of patients with R/R NPM1m #AML, revumenib was associated with a clinically meaningful response while retaining a safety profile consistent with previous findings. Published in @bloodjournals.hematology.org.

https://bit.ly/4ode7AQ

#leusm

Revumenib Shows Promise in Treating NPM1-Mutated Relapsed/Refractory AML

Researchers determined revumenib showed promising efficacy in patients with R/R NPM1m AML.

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Hematology Advisor @hematologyadvisor.bsky.social · 6d

Single men with #cancer reported feeling overlooked by their #HCPs. Published in @oncologynurseadv.bsky.social.

https://bit.ly/4qocy4w

#cancercare

Single Men With Cancer Have More Negative Experiences With Their HCPs

In focus group interviews, married men with cancer reported better experiences for themselves and their caregivers with healthcare providers, compared with their single counterparts. Married men with cancer reported better experiences for themselves and...

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Hematology Advisor @hematologyadvisor.bsky.social · 7d

Children in the US will have either relied on publicly subsidized insurance or experienced periods without any insurance during the post-ACA, prepandemic policy era. Recent reductions in #Medicaid funding may worsen existing gaps. From @jama.com @clinicalpainadv.bsky.social.

https://bit.ly/4o4svvq

Reduced Medicaid Funding May Worsen Risk for Coverage Gaps in American Children

Key findings on insurance dynamics for American children (post-ACA, prepandemic): 42% ever uninsured, 61% ever on Medicaid/CHIP.

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Hematology Advisor @hematologyadvisor.bsky.social · 8d

TFR is a feasible target for patients with #CML living in low- and middle-income countries, according to research presented at #ESMO25.

https://bit.ly/4727w6m

#leusm

Patients With CML Living in LMICs May Reach High TFR Rates - Hematology Advisor

Researchers evaluated long-term outcomes among patients with CML living in LMICs who received imatinib through financial assistance from the Max Foundation.

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Hematology Advisor @hematologyadvisor.bsky.social · 9d

Many patients with #CLL/#SLL who were intolerant of ibrutinib and/or acalabrutinib were able to tolerate and benefit from zanubrutinib. Published in @bloodjournals.hematology.org.

https://bit.ly/4o0q7Wd

#leusm

Zanubrutinib May Benefit CLL/SLL Patients Intolerant of Other BTK Inhibitors

Researchers determined zanubrutinib may be effective for patients with CLL/SLL who were intolerant to other BTK inhibitors.

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Hematology Advisor @hematologyadvisor.bsky.social · 10d

RAS mutations are strong predictors of poor prognosis among adult patients with #myelodysplasticSyndrome. Presented at #ESMO25.

https://bit.ly/47i9xdp

#MDS

RAS Mutational Status Predictive of OS, PFS in Adult MDS - Hematology Advisor

Researchers sought to assess whether RAS mutational status was predictive of survival for patients with MDS.

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Hematology Advisor @hematologyadvisor.bsky.social · 11d

Preliminary results from a phase 2 study suggest that the combination of tislelizumab with chidamide, lenalidomide, and etoposide may be effective for the treatment of R/R ENKTL. Presented at #ESMO25.

https://bit.ly/4ovkEGT

#lymsm

Combination Therapy With Tislelizumab May Be Effective in ENKTL - Hematology Advisor

Researchers sought to determine whether combination therapy with tislelizumab would be effective in treating patients with ENKTL.

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Hematology Advisor @hematologyadvisor.bsky.social · 12d

The arrival of the #Trump administration brought an avalanche of political changes in the US, including within the #healthcare sector, slashing funding for key research programs.

https://bit.ly/474ugkS

#HemOnc #layoffs

ASH Works to Support Hematologists, Patients Through Uncertain Political Period

ASH President Belinda R. Avalos, MD, shares perspective on recent political changes and how ASH is supporting hematologists' research.

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Hematology Advisor @hematologyadvisor.bsky.social · 12d

@ash.hematology.org President @b-avalos-md.bsky.social shares her perspectives on the past year’s political changes and how they are affecting #hematology research and care.

bit.ly/474ugkS

ASH Works to Support Hematologists, Patients Through Uncertain Political Period

ASH President Belinda R. Avalos, MD, shares perspective on recent political changes and how ASH is supporting hematologists' research.

bit.ly

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Hematology Advisor @hematologyadvisor.bsky.social · 13d

New insights into #hemophilia A were reported in a study based on an upgrade of a database of unique variants associated with plasma FVIII.

https://bit.ly/43vhLh7

Hematology Advisor @hematologyadvisor.bsky.social · 14d

The combined use of isatuximab and cemiplimab showed persistent antitumor activity alongside a manageable safety profile among patients with R/R ENKTL. From @hematologyadvisor.bsky.social.

https://bit.ly/4qaQavt

#lymsm

Combination Isatuximab and Cemiplimab Effective, Safe in Treating R/R ENKTL - Oncology Nurse Advisor

Researchers sought to determine whether isatuximab and cemiplimab would be safe and effective for patients with relapsed/refractory extranodal NK/T-cell lymphoma.

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Hematology Advisor @hematologyadvisor.bsky.social · 14d

Efmoroctocog alfa appears to be effective in extended half-life factor VIII replacement and surgical management in patients with #hemophilia A. From @rarediseaseadvisor.bsky.social.

https://bit.ly/4o0bIcY

Efmoroctocog Alfa May Reduce Treatment Burden and Increase Bleed Protection in Hemophilia

Surgical cases were successfully managed with efmoroctocog alfa, including a dental extraction, circumcision, and orthopedic fracture refixation.

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Hematology Advisor @hematologyadvisor.bsky.social · 15d

Albuminuria is linked to myriad #cancer risks in adults, independent of eGFR and diabetes, a large study finds. From @renalurologynews.bsky.social.

https://bit.ly/4qdlmtU

#cancerrisk

Albuminuria Linked With Increased Cancer Risks

Investigators assessed markers of chronic kidney disease (CKD) with cancer risks using data from more than one million patients.

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Hematology Advisor @hematologyadvisor.bsky.social · 16d

Risk for VTE after an operation for #colorectalcancer is higher among patients with IBD. Published in @gastroadvisor.bsky.social.

https://bit.ly/47myJAJ

#crcsm

High Risk for Venous Thromboembolism After CRC Surgery in Adults With IBD

Individuals with IBD have an increased risk for venous thromboembolism following an operation for CRC.

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Hematology Advisor @hematologyadvisor.bsky.social · 17d

Individuals with #hemophilia B without inhibitors do not exhibit an elevated risk for kidney dysfunction or damage compared with the general population. Reported in @rarediseaseadvisor.bsky.social.

https://bit.ly/4n248Nr

No Elevated Risk for Renal Dysfunction Seen in Hemophilia B Patients Without Inhibitors

In the B-Natural study, patients with severe hemophilia (ie, factor IX <1%) and/or a history of inhibitors demonstrated a broader range of estimated glomerular filtration rate values.

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Hematology Advisor @hematologyadvisor.bsky.social · 19d

@ash.hematology.org President Belinda R. Avalos, MD, shares her perspectives on the past year’s political changes and how they are affecting #hematology research and care.

https://bit.ly/474ugkS

#HemOnc

ASH Works to Support Hematologists, Patients Through Uncertain Political Period

ASH President Belinda R. Avalos, MD, shares perspective on recent political changes and how ASH is supporting hematologists' research.

bit.ly

Hematology Advisor @hematologyadvisor.bsky.social · 21d

Teclistamab-based induction regimens have demonstrated efficacy in patients with newly diagnosed #multipleMyeloma. Presented at #IMS2025, covered by @cancertherapyadv.bsky.social.

https://bit.ly/438ADSX

Teclistamab-Based Induction Regimens Produce “Very High” MRD Negativity Rates

Teclistamab-based induction regimens have demonstrated efficacy in a phase 2 trial of patients with newly diagnosed multiple myeloma.

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Hematology Advisor @hematologyadvisor.bsky.social · 22d

An unusual case has been reported of cold AIHA, of which CAD is a form, evolving to #CLL. Presented at #SOHO2025, covered by @rarediseaseadvisor.bsky.social.

https://bit.ly/3KAOF9H

#leusm

Cold AIHA May Signal Future Risk of CLL: A Case Report

Molecular analysis revealed a hypermutation in the immunoglobulin heavy chain region, indicating a more indolent form of CLL and a better prognosis.

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Hematology Advisor @hematologyadvisor.bsky.social · 24d

The pharmacokinetic response of FVIII to desmopressin shows marked interindividual variability among female #hemophilia A carriers. Published in @bloodjournals.hematology.org and @rarediseaseadvisor.bsky.social.

https://bit.ly/4nCAMWX

Study Identifies Determinants of Desmopressin Response in Female Hemophilia A Carriers

Basal von Willebrand factor antigen levels influenced FVIII kinetics, with lower von Willebrand factor antigen associated with higher postdesmopressin FVIII peaks and recovery.

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