Gabriel Negreira
@gnegreira.bsky.social
59 followers
90 following
8 posts
#Leishmaniac, #FWO junior postdoc at @itmantwerp.bsky.social.
Using #singlecellgenomics to understand Aneuploidy and Genome instability in #Leishmania.
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Gabriel Negreira
@gnegreira.bsky.social
· Sep 11
A novel high-throughput single-cell DNA sequencing method reveals hidden genomic heterogeneity in the unicellular eukaryote Leishmania
Genome instability is considered a major driver of adaptation in eukaryotic microorganisms, but its study is hampered by the limited availability of genomic technologies with single-cell resolution. H...
www.biorxiv.org
Gabriel Negreira
@gnegreira.bsky.social
· Sep 11
Single Cell CNV | 10x Genomics
Chromium Single Cell CNV provides a comprehensive, scalable solution for revealing genome heterogeneity and understanding clonal evolution. Study disease pathogenesis or characterize neuronal mosaicis...
www.10xgenomics.com
Gabriel Negreira
@gnegreira.bsky.social
· Sep 11
The adaptive roles of aneuploidy and polyclonality in Leishmania in response to environmental stress | EMBO reports
image image The dynamics of aneuploidy, a hallmark of Leishmania adaptation, depends on the nature and strength of the environmental stress as well
as on the existence of other pre‐adaptive mechanism...
www.embopress.org
Gabriel Negreira
@gnegreira.bsky.social
· Sep 11
High throughput single-cell genome sequencing gives insights into the generation and evolution of mosaic aneuploidy in Leishmania donovani
Abstract. Leishmania, a unicellular eukaryotic parasite, is a unique model for aneuploidy and cellular heterogeneity, along with their potential role in ad
academic.oup.com
Gabriel Negreira
@gnegreira.bsky.social
· Sep 11
Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level - Scientific Reports
Scientific Reports - Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level
www.nature.com
Reposted by Gabriel Negreira
Reposted by Gabriel Negreira
Richard McCulloch
@rmc9z.bsky.social
· Feb 10
R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania - Nature Communications
All genomes are replicated in a temporal order, though the determinants of such timing are poorly characterized. Here, the authors show that the unusual chromosome size-dependent DNA replication timin...
www.nature.com
Reposted by Gabriel Negreira
