Call for CANGlia 2026 Symposia Proposals | Deadline: December 31st, 2025 The Canadian Association for Neuroscientists who study Glia (CANGlia) is now accepting Proposals for the 2026 CANGlia Meeting in Montreal (May 15-16th, 2026), with a deadline of Wednesday, December 31st, 2025. Please see below for more details and do not hesitate to reach out …

Flaviviruses can cause fatal infections of the CNS; thus, a better understanding of flaviviral pathogenesis could help to identify potential therapeutic targets. Noting that the kinase RIPK3 plays a proinflammatory role in neurons during flavivirus infection, Lindman et al. used mouse models to investigate its role in astrocytes, which help to maintain the blood-brain barrier (BBB). During flavivirus infection of mice, RIPK3 stimulated the expression of Serpina3N in astrocytes, which limited immune cell recruitment into the CNS by promoting BBB integrity, thus increasing survival. Together, these findings suggest that astrocytic RIPK3 promotes host protection during CNS viral infections. —John F. Foley

Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve neuronal function is to promote endogenous myelin repair by oligodendrocyte precursor cells (OPCs). Extracellular vesicles (EVs) secreted by pro-regenerative microglia have been shown to enhance OPC maturation and remyelination across different experimental m...

Restoring the transport and concentration of vitamin C, which is deficient in the brain cells of Alzheimer's patients, may be important for delaying the onset and progression of the disease.

Astrocyte diversity is greatly influenced by local environmental modulation. Wang et al. report a critical role for astrocytic primary cilia in transmitting local cues that drive the region-specific diversification of astrocytes within the developing mouse brain.