Fabai Wu
@fabaiwu.bsky.social
Ass Prof of Microbiology at EITech Ningbo. www.microwulab.com
Pinned
Fabai Wu
@fabaiwu.bsky.social
· 26d
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
www.nature.com
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
Reposted by Fabai Wu
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Asgards everyday! Another boost to the metabolism at the prokaryote-eukaryote interface.
November 11, 2025 at 1:22 AM
Asgards everyday! Another boost to the metabolism at the prokaryote-eukaryote interface.
Reposted by Fabai Wu
I'm happy to announce the latest release of the GlobDB, available at globdb.org.
The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
home | GlobDB
globdb.org
June 10, 2025 at 11:20 AM
I'm happy to announce the latest release of the GlobDB, available at globdb.org.
The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
The GlobDB is a database of "species dereplicated" microbial genomes, and as of release 226 contains twice the number of species-representative genomes (306,260) than the latest GTDB release.
Reposted by Fabai Wu
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
October 24, 2025 at 12:58 PM
Bacteria rely on retrons for #phage defense, but most known systems come from clinical or lab strains. @seth-shipman.bsky.social &co identify diverse #retrons from environmental #bacteria, uncovering their defense mechanisms & using them as #GenomeEditing tools @plosbiology.org 🧪 plos.io/4oDqRAF
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to eukaryotic DNA replication machinery. 🧪
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
www.nature.com
October 24, 2025 at 12:43 PM
Reposted by Fabai Wu
chromosome replicationists – #Archaea branch, Asgard dept. – take note 👇
#ArchaeaSky
thx @acritschristoph.bsky.social for boosting this 🙏
#ArchaeaSky
thx @acritschristoph.bsky.social for boosting this 🙏
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
www.nature.com
October 21, 2025 at 6:52 PM
chromosome replicationists – #Archaea branch, Asgard dept. – take note 👇
#ArchaeaSky
thx @acritschristoph.bsky.social for boosting this 🙏
#ArchaeaSky
thx @acritschristoph.bsky.social for boosting this 🙏
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor - Nature Ecology & Evolution
Phylogenetic and biochemical analyses show a diversity of components of the DNA replication machinery in different Asgard archaea that contributed to the eukaryotic DNA replication machinery.
www.nature.com
October 21, 2025 at 3:06 PM
Glad to share our paper out today @NatureEcoEvo: “Serial innovations by Asgard archaea shaped the DNA replication machinery of the early eukaryotic ancestor”. www.nature.com/articles/s41... #microsky #archaeasky
Reposted by Fabai Wu
Latest #CDlab paper on @biorxivpreprint.bsky.social: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
April 25, 2025 at 8:30 AM
Latest #CDlab paper on @biorxivpreprint.bsky.social: Spatial control of karyopherin binding avidity in NPC mimics revealed by designer FG-Nucleoporins
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
www.biorxiv.org/content/10.1...
With experiments & MD simulations we study de novo designed proteins for selective transport through nuclear pores
Reposted by Fabai Wu
It is the year of the (more?) complex prok multicellularity :)
Fascinating new PLoS Biology paper from George Schaible et al in the Hatzenpichler Lab at Montana State
“𝘈𝘴 𝘵𝘩𝘦 𝘰𝘯𝘭𝘺 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘵𝘩𝘢𝘵 𝘦𝘹𝘩𝘪𝘣𝘪𝘵 𝘰𝘣𝘭𝘪𝘨𝘢𝘵𝘦 𝘮𝘶𝘭𝘵𝘪𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳𝘪𝘵𝘺, 𝘔𝘔𝘉 𝘱𝘳𝘰𝘷𝘪𝘥𝘦 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘦 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘣𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘪𝘴 𝘱𝘳𝘰𝘧𝘰𝘶𝘯𝘥 𝘴𝘵𝘦𝘱 𝘪𝘯 𝘭𝘪𝘧𝘦’𝘴 𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘢𝘳𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘯 𝘌𝘢𝘳𝘵𝘩”
“𝘈𝘴 𝘵𝘩𝘦 𝘰𝘯𝘭𝘺 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢 𝘵𝘩𝘢𝘵 𝘦𝘹𝘩𝘪𝘣𝘪𝘵 𝘰𝘣𝘭𝘪𝘨𝘢𝘵𝘦 𝘮𝘶𝘭𝘵𝘪𝘤𝘦𝘭𝘭𝘶𝘭𝘢𝘳𝘪𝘵𝘺, 𝘔𝘔𝘉 𝘱𝘳𝘰𝘷𝘪𝘥𝘦 𝘢𝘯 𝘪𝘮𝘱𝘰𝘳𝘵𝘢𝘯𝘵 𝘦𝘹𝘢𝘮𝘱𝘭𝘦 𝘰𝘧 𝘱𝘰𝘴𝘴𝘪𝘣𝘭𝘦 𝘮𝘦𝘤𝘩𝘢𝘯𝘪𝘴𝘮𝘴 𝘣𝘦𝘩𝘪𝘯𝘥 𝘵𝘩𝘪𝘴 𝘱𝘳𝘰𝘧𝘰𝘶𝘯𝘥 𝘴𝘵𝘦𝘱 𝘪𝘯 𝘭𝘪𝘧𝘦’𝘴 𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘢𝘳𝘺 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘯 𝘌𝘢𝘳𝘵𝘩”
These Tiny Magnetic Bacteria Act Like a Single Body – And Could Explain the Origins of Complex Life
Tiny magnetic bacteria that live in tightly bound groups are showing scientists how life might have evolved complex, multicellular forms. These rare bacteria can’t survive alone – they depend on one a...
scitechdaily.com
April 9, 2025 at 1:18 PM
It is the year of the (more?) complex prok multicellularity :)
Reposted by Fabai Wu
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
The 2026 Biochemical Society Award for Significant Breakthrough or Achievement is presented to Cees Dekker @ceesdekker.bsky.social! Celebrating his ground-breaking contributions to nanotechnology, Cees has pioneered research on solid-state nanopores and nanopore-based DNA sequencing.
April 8, 2025 at 8:30 AM
Wow, I feel greatly honored by being awarded the 2026 Biochemical Society Award for Significant Breakthrough or Achievement, as was just announced!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
www.biochemistry.org/about-us/new...
It is wonderful that the Biochemical Society honors our contributions to single-molecule biophysics in this way!
Reposted by Fabai Wu
Sooo cool! Congrats @archaeon-alex.bsky.social and Co.!
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
April 4, 2025 at 8:47 AM
Sooo cool! Congrats @archaeon-alex.bsky.social and Co.!
We are looking for tenure-track and tenured biologists to join our department: School of Life Sciences at EITech Ningbo. It's a new private university, English taught, benefits and selection are both internationally competitive. Please apply & contact me if you have any questions. shorturl.at/Rjqku
Tenure-Track and Tenured Positions in Life Sciences, Biotechnology, and Biomedical Engineering - Ningbo, Zhejiang (CN) job with Eastern Institute of Technology, Ningbo - Global Engagement Office | 128...
Seeking dynamic and outstanding individuals to join us in the College of Science and College of Engineering to expand our research capabilities.
www.nature.com
April 4, 2025 at 2:54 PM
We are looking for tenure-track and tenured biologists to join our department: School of Life Sciences at EITech Ningbo. It's a new private university, English taught, benefits and selection are both internationally competitive. Please apply & contact me if you have any questions. shorturl.at/Rjqku