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Reposted by Emmanuel Beaurepaire

Laboratory for Optics and Biosciences @laboptbio.bsky.social · 7d

(2025/10/08) Congratulations to @chiarastringari.bsky.social on the defense of her Habilitation à Diriger les Recherches (HDR) "Label-free multimodal non-linear optical microscopy for functional imaging of living tissues" !

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Sep 16

I first understood that you published with your husband and your wife - separate papers 😂

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Reposted by Emmanuel Beaurepaire

Nicolas Chiaruttini @nkiaru.bsky.social · Jul 24

Hey, it's out!
doi.org/10.1016/j.ce... Aligning Big Brains and Atlases, ABBA in short, is published in Cell Reports @cp-cellreports.bsky.social . @biancasilvalab.bsky.social's lab added an analysis pipeline on top of it (BraiAn) and did all the relevant biological work. What is it ? Short thread:

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 18

petroleum 😅

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

Happy to finally publish this work… Congrats authors and thanks funders @agencerecherche.bsky.social #FondationBettencourtSchueller‬‬‬

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

These findings help to establish THG microscopy as a quantitative, multiscale imaging technique, paving the way for new applications. 📖 #Neuroscience #Myelin #THG #Microscopy #Research

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

Finally, we illustrate the relevance of pTHG microscopy for characterizing myelin distribution at different scales in fixed mouse and human brain tissue.

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

Fun fact for multiphoton microscopy geeks: aberrations caused by vertical micro-interfaces appear to be a significant contrast mechanism in polarized THG imaging. 😎

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

We show that axons exhibit complex pTHG profiles that depend on axon morphology and can't be explained by classical models. We establish a numerical strategy to relate pTHG profiles to axon diameter and myelin thickness, taking into account myelin-induced optical aberrations.

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

Our study presents a systematic characterization of polarized THG (pTHG) signals from individual axons, enabling the derivation of myelin scores in various systems. 🐭🐟
We confirm the sensitivity of THG for myelin in mouse tissue and detect early axon development in zebrafish.

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

By #J_Morizet #N_Olivier #MS_Aigrot #P_Mahou #E_Martin #A_Desmazieres #B_Stankoff @chiarastringari.bsky.social

🔬🌟 Find out how Third Harmonic Generation (THG) microscopy could help advance myelin biomedical research! 🧠

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jul 16

Multiscale characterization of myelin distribution with polarized THG microscopy
Morizet et al, Optica 2025 doi.org/10.1364/OPTI...

@laboptbio.bsky.social @institutducerveau.bsky.social @cnrs.fr ‪‪ @ip-paris.bsky.social @inserm.fr
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Reposted by Emmanuel Beaurepaire

Laboratory for Optics and Biosciences @laboptbio.bsky.social · Jul 1

Congratulations to @caporalclement.bsky.social on his brilliant defence of his PhD thesis, entitled 'Quantitative Analysis of Large Volume Imaging in Developmental Neurobiology' !

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jun 25

divergence

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Reposted by Emmanuel Beaurepaire

Brice Bathellier @bathellierlab.bsky.social · Jun 15

Two postdoc positions in the lab within the ERC Synergy project "Chronology" in collaboration with S. Ostojic, M. Jazayeri and V. van Wassenhove @virginievanw.bsky.social . Two focuses: sound sequences representations across the brain & novel all-optical technology. Contact: [email protected]

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jun 7

movie theaters :)

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jun 7

+1

Reposted by Emmanuel Beaurepaire

Ignacio Arganda-Carreras @iarganda.bsky.social · May 13

🆕 We're hiring! We're looking for postdoc 🎓 candidates to work at the intersaction of bioimage analysis 🖥️🔬, tissue biomechanics 🧫, and neuroscience 🧠.

👉 Application deadline: 2025/06/02
👉 Duration: July 2025 - December 2026 (for now)

Come work with us! 🤗

dipc.ehu.eus/en/dipc/join...

Joint Postdoctoral Position in Biophysics – Bioimage Analysis / AI / Neuroscience

dipc.ehu.eus

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Reposted by Emmanuel Beaurepaire

Laboratory for Optics and Biosciences @laboptbio.bsky.social · Apr 9

Congratulations to Stella Dees for defending her thesis on "Multicontrast 3P-microscopy for biological tissue imaging"

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Reposted by Emmanuel Beaurepaire

Laboratory for Optics and Biosciences @laboptbio.bsky.social · Apr 7

Congratulation to Giulia Galante for her thesis defense about the "Characterization and physico-chemical monitoring of collagen degradation in parchments by polarization-resolved multiphoton microscopy!

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Reposted by Emmanuel Beaurepaire

Chiara Stringari @chiarastringari.bsky.social · Feb 13

See you on Friday February 21st for the @eurobioimaging.bsky.social Virtual Pub on "Fluorescence Lifetime Microscopy (FLIM) for label-free metabolic imaging of living tissues"!
#FLIM #labelfree #microscopy #metabolism

You can register online here!
www.eurobioimaging.eu/events/flim-...

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Reposted by Emmanuel Beaurepaire

Chiara Stringari @chiarastringari.bsky.social · Feb 13

Do you need to analyze your FLIM data with open source software?
The #Virtual #I2K2024 workshop on "Interactive #phasor analysis of #FLIM data using FLUTE" given by Bahar Asadipour is online. www.youtube.com/watch?v=q7W1...
#FLUTE can analyze data of most commercial cards
github.com/LaboratoryOp...

Interactive phasor analysis of FLIM data using FLUTE

YouTube video by I2K Conference

www.youtube.com

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jan 22

True, but it is also a matter of disseminating scientific knowledge. Biology has made tremendous and rapid progress in the last century, with consequences for medicine. (So has physics (not to mention computer science 😂)).

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Emmanuel Beaurepaire @ebeaurepaire.bsky.social · Jan 22

Un poste d’ingénieur en analyse d’images est ouvert en mobilité pour rejoindre @laboptbio.bsky.social à @polytechniqueparis.bsky.social (Palaiseau). Poste IR ouvert aux IE de la fonction publique et IR @cnrs.bsky.social. Deadline: 20/02. Lien (concours 508): profilsdemplois.cnrs.fr/ords/afipprd...

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