Well this might help differentiate between iatrogenic and sporadic CAA - especially important in older people - and then why deep pathology? Subtle inflammation? Do we need a closer look at sporadic CAA?

V grateful to patients who share their stories, making these steps forward possible 🙏🏽 … 2/2 🧵

New in JNNP - the next chapter in the story of iatrogenic CAA 📕 and it really does seem to be different to sporadic CAA. Presence of deep haemorrhagic pathology in particular is unexpected but persistent signal.

So what does this mean? … 1/2🧵

jnnp.bmj.com/content/earl...

It’s certainly the most comprehensive meta-analysis I’ve ever been involved with 🤓

TLDR: non-motor symptoms after stroke are common across domains and guess what? Not a great deal has changed in the last decade. A real wake up call to the field to address this huge unmet need

ja.ma/3EMdegV

So is it inflammation rather than acute cSAH that drives TFNE?🐔vs🥚but anatomical localisation of inflammation with symptoms is v. interesting... and then should we be treating TFNE with steroids?? 🤔

Seems there's more inflammation in regular CAA than we ever suspected... 2/2

We tend to think of CAA-related inflammation as its own separate thing - but is this right?

@AminaSellimi @UCLStrokeRes et al have found inflammation in people with prolonged TFNE (amyloid spells) - even though they all had "non-inflammatory" CAA... 1/2

onlinelibrary.wiley.com/doi/10.1002/...

Misty walk earlier today

Why is this important and/or relevant?

(1) Not all patients with CAA-ri have classical white matter changes, so these features could support diagnosis;

(2) This could help CAA-ri be diagnosed (and treated) earlier, winding back the clock for defining "early" CAA-ri ⏰

…2/2

We define CAA-ri by classical (asymmetrical, waxing/waning) white matter changes - this paper, new from the UCL Stroke Research Centre, describes imaging features of inflammation in CAA-ri that appear *before* these white matter changes ...1/2

www.neurology.org/doi/10.1212/...

Stretching my legs after an intense morning of writing