Deepak Saini
@dpak.bsky.social
PhD Candidate in the Pastor Lab | McGill University | Developmental Epigenetics | Transposable Elements are pretty darn cool
Pinned
Deepak Saini
@dpak.bsky.social
· Oct 20
Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells
Transcriptional regulation of transposons and genes by TRIM28 and 5mC is critical for proper mammalian embryonic development, but the specific roles for these mediators in human embryonic and placenta...
www.biorxiv.org
New pre-print!🚨
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Reposted by Deepak Saini
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 25, 2025 at 12:16 PM
A new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Deepak Saini
Our #Epi2025 Trainee Session honoring the legacy of C. David Allis was an incredible success last night! Huge thank you to our selected trainees for sharing their outstanding research, and to our session chairs for organizing such a thoughtful introduction honoring Dave.
November 5, 2025 at 1:27 PM
Our #Epi2025 Trainee Session honoring the legacy of C. David Allis was an incredible success last night! Huge thank you to our selected trainees for sharing their outstanding research, and to our session chairs for organizing such a thoughtful introduction honoring Dave.
Excited to be attending the #EpiCypher2025 conference in beautiful Cancun! I’ll be giving a talk on our latest work on TRIM28, DNA methylation and p53 lineage regulation in human stem cells. Looking forward to connecting with everyone there! ☀️🧬🌴
We’ve landed in Cancún for the EpiCypher 2025 Conference!
Kicking things off with some seriously gorgeous hotel views. Ready for a week of chromatin science and great conversations. 🌞
#EpiCypher2025 #Epigenetics
Kicking things off with some seriously gorgeous hotel views. Ready for a week of chromatin science and great conversations. 🌞
#EpiCypher2025 #Epigenetics
November 3, 2025 at 7:44 PM
Excited to be attending the #EpiCypher2025 conference in beautiful Cancun! I’ll be giving a talk on our latest work on TRIM28, DNA methylation and p53 lineage regulation in human stem cells. Looking forward to connecting with everyone there! ☀️🧬🌴
Reposted by Deepak Saini
What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
A cytosolic function of DNMT1 controls neuronal morphogenesis via microtubule regulation
Proteins traditionally confined to a single cellular compartment are increasingly recognized to exert non-canonical functions in alternative domains. The DNA methyltransferase 1 (DNMT1), classically d...
www.biorxiv.org
October 20, 2025 at 9:09 AM
What if the DNA methylation enzyme DNMT1 isn’t just about DNA?
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
Our new preprint reveals a cytosolic role for DNMT1 as a scaffold controlling neuronal morphology via DOCK7–Rac1/STMN1 signaling & mitochondrial trafficking.
A paradigm shift in DNMT1 biology! www.biorxiv.org/content/10.1...
New pre-print!🚨
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Divergent roles of DNA methylation, TRIM28, and p53 surveillance in human embryonic and trophoblast stem cells
Transcriptional regulation of transposons and genes by TRIM28 and 5mC is critical for proper mammalian embryonic development, but the specific roles for these mediators in human embryonic and placenta...
www.biorxiv.org
October 20, 2025 at 10:20 AM
New pre-print!🚨
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Ever curious about TE regulation by TRIM28 in placental stem cells? Or what happens to embryonic and trophoblast stem cells when you lose DNA methylation?
We explore those questions here!
www.biorxiv.org/content/10.1...
Reposted by Deepak Saini
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
DNA methylation influences human centromere positioning and function - Nature Genetics
Genome-wide and targeted perturbation of DNA methylation at centromeres affects CENP-A positioning and centromere structure, resulting in aneuploidy and reduced cell viability.
www.nature.com
September 4, 2025 at 1:10 PM
#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
Beautiful work by Adda! Definitely worth a read!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Engulfing to Adapt: Efferocytosis by Epithelial Cells Triggers Cell State Transitions During Tissue Remodeling
Hormone deprivation treatments are a leading approach in prostate cancer treatment. Following deprivation, the organ regresses from a fully differentiated secretory organ to one less than 50% of the o...
www.biorxiv.org
August 4, 2025 at 8:44 PM
Beautiful work by Adda! Definitely worth a read!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Looks like I got hacked on twitter, oh well nothing of value lost 🤣
January 24, 2025 at 12:54 AM
Looks like I got hacked on twitter, oh well nothing of value lost 🤣