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Reposted by David Gaboriau

Denis Duboule @denisduboule.bsky.social · 5h

Tomorrow wednesday October 15th at 11am, first seminar of @neilshubin.bsky.social , guest Professor @college-de-france.fr on ‘The history we share with fish’. Come, have a seat and enjoy learning where we come from. Free knowledge, no registration🤘

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David Gaboriau @dgaboriau.bsky.social · 20h

C’est quel parc?

Reposted by David Gaboriau

Giulia Bertolin @bertolingiulia.bsky.social · 1d

Excited to share our #BioSenSRRF preprint on bioRxiv! 🎉
We show how SRRF microscopy can be used with FRET-based biosensors to 🔬mitochondrial functions with high resolution 😍.
Code and test data are open (GitHub + Zenodo).
👏 to Nicolas, Pierre-Jean, and co-authors! www.biorxiv.org/content/10.1...

Combining FRET and super-resolution microscopy reveals kinase activation and mitochondrial activity at the nanoscale

Protein kinases are key regulators of intracellular signaling, showing activities in specific subcellular compartments and in micro- or nano-domains. Genetically encoded biosensors based on Förster′s ...

www.biorxiv.org

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Imperial Medicine @imperialmed.bsky.social · 1d

From Imperial labs to a $4.9 billion Pfizer acquisition 🌟

#GLP1 pioneer Prof Steve Bloom’s #obesity drug candidates, invented at @imperialmdr.bsky.social, are at the heart of @metserainc.bsky.social’s deal with Pfizer — driving next-gen treatments.

www.imperial.ac.uk/news/269453/...

Pfizer aims to bring Imperial obesity drug candidates to clinic in $4.9bn deal | Imperial News | Imperial College London

Multinational bets on candidates invented by GLP-1 pioneer Professor Steve Bloom to propel it into the race for next-generation obesity treatments.

www.imperial.ac.uk

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Turku BioImaging @turkubioimaging.bsky.social · 3d

🚀Join Helsinki BioImaging as an Image Analysis Specialist🖥️to support cross-disciplinary image analysis projects. If you love coding and are interested in working at the crossroads of computer science and biology, apply by 🗓️ November 15, 2025⤵️
jobs.helsinki.fi/job/Helsinki...
#jobopening

Image Analysis Specialist/Engineer/Coordinator, Helsinki Bioimaging

jobs.helsinki.fi

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David Gaboriau @dgaboriau.bsky.social · 3d

it's 12 Monkeys, without the monkeys...

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Anne Carpenter @drannecarpenter.bsky.social · 3d

15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵

mitochondria from bipolar patients are closer to the nucleus in these images; control patients' are spread out further

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David Gaboriau @dgaboriau.bsky.social · 3d

I still haven't recovered from Station Eleven... Hope you like it as much as I did!

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David Gaboriau @dgaboriau.bsky.social · 4d

They jumped right at me :) and look fantastic as prints!

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David Gaboriau @dgaboriau.bsky.social · 4d

I was watching the very nice "Secrets of the Brain" on the BBC with @jimalkhalili.bsky.social, and thought: hang on, I know that image! Bravo @christlet.bsky.social 🎉

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David Gaboriau @dgaboriau.bsky.social · 5d

Mince! Wishing you a prompt recovery!

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David Gaboriau @dgaboriau.bsky.social · 5d

Wait what

Cameron Thrash @jcamthrash.bsky.social · 5d

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope www.nature.com/articles/s41... #jcampubs

Direct single-molecule detection and super-resolution imaging with a low-cost portable smartphone-based microscope - Nature Communications

Loretan and colleagues present a low-cost smartphone-based microscope capable of detecting single-molecule fluorescence. This approach opens doors to personalised and widely distributed applications in diagnostics, biosensing, and science education.

www.nature.com

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David Gaboriau @dgaboriau.bsky.social · 5d

Glad you and your family are ok! Good idea to take the photos!

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Reposted by David Gaboriau

Cahir O'Kane @cahirokane.bsky.social · 6d

Sad to hear of the death of John Gurdon this morning, aged 92.

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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David Gaboriau @dgaboriau.bsky.social · 6d

Top position in Paris with Jean-Yves @jytinevez.bsky.social

#bioimageanalysis 🔬

Jean-Yves Tinevez @jytinevez.bsky.social · 7d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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David Gaboriau @dgaboriau.bsky.social · 7d

Ahead of the Physics Nobel tomorrow, a thread on a Nobel not as famous as others.

Nonetheless, Lippmann had that ace quote:

“Life is short and progress is slow.” 👌

Margaret Harris @drmlharris.bsky.social · 7d

And the funny thing is, Lippmann knew this. He even ended his Nobel Prize lecture by acknowledging that, at over one minute, the exposure times for his method were “too long for the portrait”. Though further improvements were possible, he concluded, “Life is short and progress is slow.” (7/n) 🧪⚛️

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David Gaboriau @dgaboriau.bsky.social · 9d

Antibodies are fickle things!
I hope it works out for your IF!

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David Gaboriau @dgaboriau.bsky.social · 10d

Neat playlists!

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Reposted by David Gaboriau

Christophe 🔬 L @christlet.bsky.social · 11d

Want to hear a mid-career PI pontificate about science, career and cooking? Today's your lucky day thanks to The Microscopists podcast! Thanks Peter @yorkbioimaging.bsky.social for having me 🎙️🎧
themicroscopists.bitesizebio.com/episodes/chr...

The Microscopists | Christophe Leterrier (CNRS & Aix-Marseille Université)

This time on The Microscopists, we're joined by Christophe Leterrier, team leader at NeuroCyto in Marseille and director of a Nikon Center of Excellence for super-resolution microscopy.Christophe r...

themicroscopists.bitesizebio.com

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David Gaboriau @dgaboriau.bsky.social · 11d

Make one a year and give it as part of the best poster prize ☕️

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Dave Barry @david-j-barry.bsky.social · 11d

I forgot that I had this made. As a prototype that never went into full production, it's the only one in existence and, therefore, highly desirable.

Let's start the bidding at £1,809, £1 for every day since the very first CBIAS.

For an extra 50%, you can have it signed by @martinjones.bsky.social.

Crick BioImage Analysis Symposium 2024 Commemorative Mug

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David Gaboriau @dgaboriau.bsky.social · 11d

Full cell antibody purification!

Clever trick, could also work for IF or FACS

Victor Tatarskiy @greenrat.bsky.social · 11d

Neat trick if you polycolonal ab's suck. Incubate them with fixed cells with a KO of your protein of interest, then spin. Protocol here: www.med.upenn.edu/markslab/ass...
I was amazed how well it worked on first try (I'm sure that I can completely eliminate unspecific bands)
#WesternBlot #cellsky

On the left - western blot of B16F10 cells wt and KO for CDK8. Our in house produced antibodies give a lot of unspecific bands. On the right same probes with antibodies preincubated with fixed CDK8 KO cells - there is a specific band and faint unspecific bands, which can be probably eliminated with increase of amount of KO cells.

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Dr Rachel Clarke @drrachelclarke.com · 13d

Here I am in 2020 in the flimsiest, most pitful PPE - like so many other NHS staff, some of whom died from the Covid they caught in their hospitals.

Tory peer Michelle Mone - who today lost her legal case & must repay the govt £122m - dares to claim she’s been ‘scapegoated’.

What, Michelle? 🧵

Rachel wearing very flimsy looking apron, mask and visor in NHS setting

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Reposted by David Gaboriau

Cahir O'Kane @cahirokane.bsky.social · 12d

When BCE (before the confocal era) turned into CE (confocal era) - 1987

Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · 13d

New Online! The advent of confocal laser scanning microscopy in biological research

The advent of confocal laser scanning microscopy in biological research

Nature Reviews Molecular Cell Biology, Published online: 01 October 2025; doi:10.1038/s41580-025-00905-5The advent of laser-scanning confocal microscopy revolutionized cell biology, offering unprecedented resolution and depth and enabling scientists to visualize cellular structures in 3D.

bit.ly

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Reposted by David Gaboriau

Mayor of London, Sadiq Khan @london.gov.uk · 13d

184 years earlier than predicted, London has met the legal limits for toxic NO2 for the first time.

This historic milestone proves that bold action like expanding ULEZ works, protecting children’s health and giving millions cleaner air to breathe.

London Ulez reduced nitrogen dioxide to legal limit, mayor says

The mayor of London says the fall in airborne toxins is due to the Ultra low emission zone expansion.

www.bbc.co.uk

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