Daniel Zhen Ye Sin
@danielsin909.bsky.social
Phages! Microbiota! MGEs! All about the little critters living around and in us :)
PhD Student at the Penadés lab, Imperial College London
PhD Student at the Penadés lab, Imperial College London
Reposted by Daniel Zhen Ye Sin
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Non-conjugative plasmids limit their mobility to persist in nature
Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While
increased mobility can easily evolve by incorporating phage DNA into plasmids, this
is disadvantageous because it...
www.cell.com
October 22, 2025 at 1:12 PM
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
Reposted by Daniel Zhen Ye Sin
Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species.
Original idea from @albertomarina.bsky.social and, as usual, he was right.
www.biorxiv.org/content/10.1...
Original idea from @albertomarina.bsky.social and, as usual, he was right.
www.biorxiv.org/content/10.1...
Phages communicate across species to shape microbial ecosystems
Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...
www.biorxiv.org
October 14, 2025 at 1:36 PM
Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species.
Original idea from @albertomarina.bsky.social and, as usual, he was right.
www.biorxiv.org/content/10.1...
Original idea from @albertomarina.bsky.social and, as usual, he was right.
www.biorxiv.org/content/10.1...
Good morning Phage [Ph]ans! I'm so stoked to share my first preprint with the @jrpenades.bsky.social lab! We show that phages can use the arbitrium system to crosstalk and regulate lysis-lysogeny, which has huge implications in how phages shape microbial communities!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Phages communicate across species to shape microbial ecosystems
Arbitrium is a communication system that helps bacteriophages decide between lysis and lysogeny via secreted peptides. In arbitrium, the AimP peptide binds its cognate AimR receptor to repress aimX ex...
www.biorxiv.org
October 14, 2025 at 11:59 AM
Good morning Phage [Ph]ans! I'm so stoked to share my first preprint with the @jrpenades.bsky.social lab! We show that phages can use the arbitrium system to crosstalk and regulate lysis-lysogeny, which has huge implications in how phages shape microbial communities!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Daniel Zhen Ye Sin
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
September 25, 2025 at 9:29 PM
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
Thread 1/n
Incredible work!! Go check it out!
We discovered a new horizontal gene transfer mechanism: tail-less cf-PICIs hijack free phage tails extracellularly, forming infectious chimeric virions that drive both intra- and inter-species transfer among bacteria. @jonaszpatkowski.bsky.social @tcostalab.bsky.social @jrpenades.bsky.social
September 10, 2025 at 12:55 PM
Incredible work!! Go check it out!
Reposted by Daniel Zhen Ye Sin
Virtual Virology is back - our first ever phage session. Do join us...
May 8, 2025 at 6:09 PM
Virtual Virology is back - our first ever phage session. Do join us...
Reposted by Daniel Zhen Ye Sin
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...
(1/n) www.biorxiv.org/content/earl...
Intracellular competition shapes plasmid population dynamics
Conflicts between levels of biological organization are central to evolution, from populations of multicellular organisms to selfish genetic elements in microbes. Plasmids are extrachromosomal, self-r...
www.biorxiv.org
February 21, 2025 at 8:36 PM
I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics!
(1/n) www.biorxiv.org/content/earl...
(1/n) www.biorxiv.org/content/earl...
Reposted by Daniel Zhen Ye Sin
It’s a rare day these days when me and my boss are both at work! But it’s always wonderful when he’s here - he buy me clothes from NYC and he help me with preparing todays lab meeting on the weekend! Really grateful to have such an amazing D2D supervisor!
February 26, 2025 at 11:43 AM
It’s a rare day these days when me and my boss are both at work! But it’s always wonderful when he’s here - he buy me clothes from NYC and he help me with preparing todays lab meeting on the weekend! Really grateful to have such an amazing D2D supervisor!
Reposted by Daniel Zhen Ye Sin
Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization https://www.biorxiv.org/content/10.1101/2025.02.11.637232v1
February 12, 2025 at 3:19 AM
Chimeric infective particles expand species boundaries in phage inducible chromosomal island mobilization https://www.biorxiv.org/content/10.1101/2025.02.11.637232v1