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Current Medical Science

@currentmedscience.bsky.social

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Current Medical Science is a peer-reviewed journal publishing original, innovative & influential insightful reviews, comments, & special topic articles across diverse medical disciplines, including biomedicine, public health, and related fields.

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Current Medical Science @currentmedscience.bsky.social · Jun 20

Cite Score Alert!

We’re proud to announce that our 2024 #CiteScore is 3.8!
We appreciate our authors, reviewers, readers, and editorial team.

Submit your research to @currentmedscience.bsky.social & be part of our growing journey!

link.springer.com/journal/11596/

#ScienceSky #medsky #academicsky

Current Medical Science @currentmedscience.bsky.social · 1h

This study in China investigates risk factors for #LymphNodeMetastasis in pT1 #ColorectalCancer, highlighting the role of deep submucosal invasion & its implications for #ClinicalManagement & #SurgicalDecisionMaking. #medsky

Read: link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 4h

This study identifies Δ#Ki67 and ΔKi67% as potent #Biomarkers for predicting response to #Anthracycline-based #Neoadjuvant #Chemotherapy in #BreastCancer, providing valuable insights for #Clinical decision-making and personalized #CancerCare. #medsky

Read:

Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer - Current Medical Science

Objective Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy (NAC) for breast cancer (BC) at present. However, 30% of early breast cancer (EBC) patients are resistant to…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 1d

This study shows that continuous ESPB enhances recovery quality in patients undergoing #MinimallyInvasiveCardiacSurgery, resulting in reduced #PostoperativePain, #Opioid use, & use of rescue #Analgesia. @fudan-university.bsky.social #medsky

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Effect of Continuous Erector Spinae Plane Block on Postoperative Recovery in Patients Undergoing Minimally Invasive Cardiac Surgery: A Prospective, Randomized Controlled Clinical Trial - Current Medical Science

Objective To investigate whether continuous erector spinae plane block (ESPB) improves the quality of recovery (QoR) and decreases postoperative acute and chronic pain in patients undergoing…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 2d

This study demonstrates the effectiveness of targeted #NextGenerationSequencing of #BronchoalveolarLavage fluid in detecting both #MycobacteriumTuberculosis and #NontuberculousMycobacteria infections, highlighting its promise as a diagnostic tool for future #Clinical use. #medsky

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Current Medical Science @currentmedscience.bsky.social · 3d

This study reveals that formyl peptide receptor 1 (FPR1) is upregulated in #PrematureRuptureofMembranes (PROM) patients, promoting #EpithelialMesenchymalTransition & #Membrane weakening, positioning FPR1 as a promising target for PROM prevention. #medsky

See:

FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition - Current Medical Science

Objective Premature rupture of membranes (PROM) is a common pregnancy disorder that is closely associated with structural weakening of fetal membranes. Studies have found that formyl peptide receptor…

link.springer.com

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Current Medical Science @currentmedscience.bsky.social · 4d

This study highlights a high prevalence of #Stroke among #Type2DiabetesMellitus patients in China, emphasizing the importance of analyzing clustered risk factors and refining risk identification strategies for high-risk groups. #medsky

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Prevalence and Risk Factors of Stroke in Inpatients with Type 2 Diabetes Mellitus in China - Current Medical Science

Objective The prevalence and the cluster characteristics of risk factors of stroke were assessed in a Chinese diabetic population. Methods Clinical data of 30 693 inpatients who were diagnosed with…

link.springer.com

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Current Medical Science @currentmedscience.bsky.social · 5d

This study reveals that low #Selenium and protein levels exacerbate #MyocardialInjury in #KeshanDisease by disrupting the PINK1/Parkin-mediated #Mitochondrial #Autophagy pathway, pointing to novel therapeutic strategies for intervention.

Read more: link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 5d

This study reveals that MMP13 promotes #DVT formation by downregulating Pdpn expression in mice, uncovering a novel pathogenic mechanism that may enhance #ClinicalDiagnosis and inform better management strategies. #medsky

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Inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn - Current Medical Science

Objective Matrix metalloproteinase 13 (MMP13) is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens, modifying…

link.springer.com

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Current Medical Science @currentmedscience.bsky.social · 6d

This study by @2024HUST examines the accuracy and proficiency of #GPT4.0 on multidimensional Japanese medical practitioner qualification exams, analyzing its response performance & revealing new opportunities for the medical field. #medsky

Read: link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 6d

Using RNA sequencing, researchers identified a novel #lncRNA, AL355974.3, that is upregulated in LGG & GBM, associated with poor prognosis, & may promote #Glioma via the FoxO pathway, highlighting its potential as a #PrognosticBiomarker. #medsky

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Gene Expression Profile Identifies LncRNA AL355974.3 As a Potential Glioma Biomarker - Current Medical Science

Objective Glioma is a central nervous system tumor arising from glial cells. Despite significant advances in diagnosis and treatment, most patients with high-grade gliomas have a poor prognosis. Many…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 7d

This study shows that prospero homeobox 1 (#Prox1) reduces #CellProliferation and #DrugResistance in #Retinoblastoma (RB) by targeting Notch1, positioning Prox1 as a potential #therapeutic target for RB. #medsky

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Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1 - Current Medical Science

Objective Retinoblastoma (RB) is a prevalent type of eye cancer in youngsters. Prospero homeobox 1 (Prox1) is a homeobox transcriptional repressor and downstream target of the proneural gene that is…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 8d

This retrospective study investigates early #NeurologicalImpairment (ENI) incidences and their influencing factors in adult #Sepsis patients, providing critical insights for improved #Neurological outcomes and advanced sepsis care. #medsky

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Risk Factors of Enternal Nutrition Intolerance in Septic Patients: A Case-control Study - Current Medical Science

Objective This study aimed to investigate the incidence of enteral nutrition intolerance (ENI) in patients with sepsis and explore potential risk factors. Methods A case-control study was conducted…

link.springer.com

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Current Medical Science @currentmedscience.bsky.social · 9d

This research reveals that knowledge base optimization significantly improves quality, accuracy, and comprehensiveness of #LLM outputs in #Orthopedics, offering clear optimization strategies. #MedicalAI #medsky

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Enhancing Orthopedic Knowledge Assessments: The Performance of Specialized Generative Language Model Optimization - Current Medical Science

Objective This study aimed to evaluate and compare the effectiveness of knowledge base-optimized and unoptimized large language models (LLMs) in the field of orthopedics to explore optimization…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 9d

This review advocates for hospitals to adopt multidimensional early warning #technologies to analyze #MedicalData and build institution-specific models for #InfectiousDiseases, thereby boosting social and #EconomicBenefits. #medsky

To read:

Identification of Early Warning Signals of Infectious Diseases in Hospitals by Integrating Clinical Treatment and Disease Prevention - Current Medical Science

The global incidence of infectious diseases has increased in recent years, posing a significant threat to human health. Hospitals typically serve as frontline institutions for detecting infectious…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 10d

This research found that low Hb, ALB, & PLT levels and elevated IL-1β are independent risk factors for poor prognosis in #PediatricSepsis, highlighting the value of early detection to improve outcomes. #ClinicalResearch #medsky

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Characteristics and Risk Factors for Pediatric Sepsis - Current Medical Science

Objective Sepsis is considered a major cause of health loss in children and had high mortality and morbidity. Currently, there is no reliable model for predicting the prognosis of pediatric patients…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 11d

This study investigates the #therapeutic potential of #intravaginal Erhuang suppositories, which regulate #Immune responses and inhibit #Proteasome activity, offering promising avenues for targeting high-risk #HumanPapillomavirus. #medsky

To read:

Traditional Chinese Medicine Erhuang Suppository for Treatment of Persistent High-risk Human Papillomavirus Infection and Its Impact on Transcriptome of Uterine Cervix - Current Medical Science

Objective High-risk human papillomavirus (HR-HPV) infection is the chief cause of cervical intraepithelial neoplasia (CIN) and cervical carcinoma. The Erhuang suppository (EHS) is a traditional…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 11d

This study offers a cell cycle-related #lncRNA-based prognostic #Nomogram model that improves risk prediction in #HCC patients, paving the way for novel #Immunotherapy strategies. #medsky

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Objective Hepatocellular carcinoma (HCC) presents substantial genetic and phenotypic diversity, making it challenging to predict patient outcomes. There is a clear need for novel biomarkers to better…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 12d

This study reveals that #lncRNA #Maternally expressed gene 3 (MEG3) suppresses #EpithelialMesenchymalTransition by modulating #Ecadherin via Snail/#MAPK regulation, positioning MEG3 as a potential #therapeutic target for #BladderCancer. #medsky

To read:

LncRNA MEG3 Inhibits the Epithelial-mesenchymal Transition of Bladder Cancer Cells through the Snail/E-cadherin Axis - Current Medical Science

Objective This study aimed to investigate the role of the long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) in the epithelial-mesenchymal transition (EMT) of bladder cancer cells and the…

link.springer.com

Current Medical Science @currentmedscience.bsky.social · 12d

This study identifies #BCL6 suppression as a promising strategy to reduce #Tfhcell differentiation, attenuate #IgE secretion, and mitigate #AirwayInflammation, thereby highlighting its therapeutic potential in #Asthma. #medsky

Read more: link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 17d

This study highlights the mechanism of circ-Astn1 overexpression in protecting high glucose damage via the miR-138-5p/SIRT1 axis in #DiabeticRetinopathy. #medsky
#OpenAccess:
doi.org/10.1007/s115...

Current Medical Science @currentmedscience.bsky.social · 18d

This research reveals that #Salidroside can boost the effectiveness of #Paclitaxel in non-small cell #LungCancer by regulating the Wnt/β-catenin signaling pathway, suggesting a potential combinatorial #therapeutic strategy. #medsky
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link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 19d

This study demonstrates that 3-BrPA enhances the anti-tumor effect of embolization, leading to more complete tumor necrosis and representing a promising combination therapy for liver cancer. #CancerTherapy #LiverCancer #medsky
Read:
doi.org/10.1007/s115...

Current Medical Science @currentmedscience.bsky.social · 20d

This research highlights the vital role of #ferroptosis in #HepatocellularCarcinoma (HCC) and presents GRINA inhibition, which induces #mitochondrial damage and ferroptosis in HCC, as a novel #therapeutic approach. #medsky
To read:
link.springer.com/article/10.1...

Current Medical Science @currentmedscience.bsky.social · 21d

This research explores the potential of the UCRT frame technique for effective closed reduction in complex pelvic injuries, demonstrating promising clinical outcomes. #PelvicFractures #HipJointReplacement #medsky
Read:
doi.org/10.1007/s115...

Current Medical Science @currentmedscience.bsky.social · 22d

This study advocates for early intervention and tailored prevention strategies for severe mental disorders in children and adolescents to mitigate the impact on their psychological well-being and development. #YouthMentalHealth #MentalHealth #medsky
Read:
link.springer.com/article/10.1...